Association of obesity with diabetic retinopathy: Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetics Study (SN-DREAMS Report no. 8)

Raman, Rajiv; Rani, Padmaja Kumari; Gnanamoorthy, Perumal; Sudhir, Rachapalle Reddi; Kumaramanikavel, Govindasamy; Sharma, Æ Tarun

doi:10.1007/s00592-009-0113-8

Cited by 129 publications

(134 citation statements)

References 31 publications

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“…This further strengthened the fact that duration of diabetes was single most common predictor which affected severity of DR [6]. According to our findings, DR may appear as early as 0-5 years of having diabetes and more than 90% of patients develop DR after 25 years of having the disease.…”

Section: Resultssupporting

confidence: 84%

“…Hence, with larger number of diabetics with higher diabetic ages reporting to the diabetic clinic, it is more likely that prevalence of complications may also be larger. In a recent, population based, cross -sectional study which was done at Chennai on urban diabetic population an 18% prevalence of DR was observed [6]. It further strengthens referral biased differences in hospital and population based studies.…”

Section: Resultsmentioning

confidence: 61%

“…Raman et al, found a prevalence of 18% in diabetic population, whereas Agrawal RP et al, found a prevalence of 28.9% in type 2 diabetic population [6,7]. Although various population and hospital based studies have been conducted in northern [7] and southern [8] parts of India to estimate the prevalence of DR in type 2 diabetic population, there is a paucity in the literature regarding the prevalence of DR in western India.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Diabetic Retinopathy in Western Indian Type 2 Diabetic Population: A Hospital – based Cross – Sectional Study

Ramavat¹

2013

JCDR

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Context: Diabetic Retinopathy (DR) can be defined as a damage which is caused to microvasculature in the retina by prolonged hyperglycaemia. Various studies have been conducted in south India, to find out prevalence of DR. It remains a less explored domain among type 2 diabetic patients in western India.Objectives: (1) To assess prevalence of diabetic retinopathy in type 2 DM in western Indian population. and (2) To find out effect of duration of diabetes on severity of DR in this population.Study Design: A hospital -based, cross -sectional study. Material and Methods:A total of 168 patients with type 2 DM underwent detailed opthalmoscopic examinations for DR. The ETDRS classification was followed to categorize retinopathy in different stages. Results:We observed that overall, prevalence of DR in type 2 patients of western India was 33.9%. Prevalences of nonproliferative DR and proliferative DR were 25.5% and 8.33% respectively. Statistically significant differences (p value<0.05) were observed between prevalences of DR in each group of patients which was classified, and duration of diabetes. Prevalence of CSME (clinically significant macular oedema) was 6.5%. Associated hypertension showed a statistically significant (p value<0.05%), higher prevalence of DR. Conclusion:This study concluded that prevalence of DR in type 2 DM patients of western India was 33.9% and that it increased with duration of diabetes. Associated hypertension is a risk factor for development of

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Section: Resultssupporting

confidence: 84%

Section: Resultsmentioning

confidence: 61%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of Diabetic Retinopathy in Western Indian Type 2 Diabetic Population: A Hospital – based Cross – Sectional Study

Ramavat¹

2013

JCDR

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“…In our previous study in subjects with type 2 diabetes aged 440 years, we reported higher prevalence of obesity defined by BMI and by WC in women than men. 25 Other populationbased studies also found a similar trend. 19,26 As previously reported, 27 we also noted a decline in MPOD with increasing distance from the centre of the fovea.…”

Section: Discussionmentioning

confidence: 52%

“…8 Furthermore, gender differences have been noted in the different obesity types in this population. 19 Hence, we divided the obese subjects in various groups using different definitions of obesity 25 and then we studied the distribution of MPOD at different eccentricities in each of this group, and compared the values with those of normal subjects.…”

Section: Discussionmentioning

confidence: 99%

Association between various types of obesity and macular pigment optical density

Gupta

Raman

Biswas

et al. 2012

Eye

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Prognostic factors for the development and progression of proliferative diabetic retinopathy in people with diabetic retinopathy

Perais

Agarwal

Evans

et al. 2023

Cochrane Database of Systematic Reviews

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Background Diabetic retinopathy (DR) is characterised by neurovascular degeneration as a result of chronic hyperglycaemia. Proliferative diabetic retinopathy (PDR) is the most serious complication of DR and can lead to total (central and peripheral) visual loss. PDR is characterised by the presence of abnormal new blood vessels, so‐called “new vessels,” at the optic disc (NVD) or elsewhere in the retina (NVE). PDR can progress to high‐risk characteristics (HRC) PDR (HRC‐PDR), which is defined by the presence of NVD more than one‐fourth to one‐third disc area in size plus vitreous haemorrhage or pre‐retinal haemorrhage, or vitreous haemorrhage or pre‐retinal haemorrhage obscuring more than one disc area. In severe cases, fibrovascular membranes grow over the retinal surface and tractional retinal detachment with sight loss can occur, despite treatment. Although most, if not all, individuals with diabetes will develop DR if they live long enough, only some progress to the sight‐threatening PDR stage. Objectives To determine risk factors for the development of PDR and HRC‐PDR in people with diabetes and DR. Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL; which contains the Cochrane Eyes and Vision Trials Register; 2022, Issue 5), Ovid MEDLINE, and Ovid Embase. The date of the search was 27 May 2022. Additionally, the search was supplemented by screening reference lists of eligible articles. There were no restrictions to language or year of publication. Selection criteria We included prospective or retrospective cohort studies and case‐control longitudinal studies evaluating prognostic factors for the development and progression of PDR, in people who have not had previous treatment for DR. The target population consisted of adults (≥18 years of age) of any gender, sexual orientation, ethnicity, socioeconomic status, and geographical location, with non‐proliferative diabetic retinopathy (NPDR) or PDR with less than HRC‐PDR, diagnosed as per standard clinical practice. Two review authors independently screened titles and abstracts, and full‐text articles, to determine eligibility; discrepancies were resolved through discussion. We considered prognostic factors measured at baseline and any other time points during the study and in any clinical setting. Outcomes were evaluated at three and eight years (± two years) or lifelong. Data collection and analysis Two review authors independently extracted data from included studies using a data extraction form that we developed and piloted prior to the data collection stage. We resolved any discrepancies through discussion. We used the Quality in Prognosis Studies (QUIPS) tool to assess risk of bias. We conducted meta‐analyses in clinically relevant groups using a random‐effects approach. We reported hazard ratios (HR), odds ratios (OR), and risk ratios (RR) separately for each available ...

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Association of obesity with diabetic retinopathy: Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetics Study (SN-DREAMS Report no. 8)

Cited by 129 publications

References 31 publications

Prevalence of Diabetic Retinopathy in Western Indian Type 2 Diabetic Population: A Hospital – based Cross – Sectional Study

Prevalence of Diabetic Retinopathy in Western Indian Type 2 Diabetic Population: A Hospital – based Cross – Sectional Study

Association between various types of obesity and macular pigment optical density

Prognostic factors for the development and progression of proliferative diabetic retinopathy in people with diabetic retinopathy

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