Association of obesity, serum glucose and lipids with the risk of advanced colorectal adenoma and cancer: A case-control study in Korea

Chung, Yong Woo; Han, Dong Soo; Park, Y.K.; Son, Bo Kyung; Paik, Chang Hee; Lee, H.L.; Jeon, Yong-Cheol; Sohn, Jung Ho

doi:10.1016/j.dld.2006.05.014

Cited by 88 publications

(75 citation statements)

References 23 publications

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“…The sixteen studies on TC (four cohort, five cross-sectional and seven case-control studies) were published between 1990 and 2013 (Tables 1 and 2) and involved a total of 21 809 CRN cases (4,9,10,(19)(20)(21)(22)25,28,29,34,36,38,39,42,43) . Three studies were conducted in the USA (20,38,39) , one in Sweden (42) , three in Korea (9,10,22) , five in Japan (25,28,29,36,43) , one in Finland (21) , one in Germany (19) and two in European countries (4,24) (Tables 1 and 2). A random-effects model was considered for a summary RR as there was evidence of heterogeneity for the included sixteen studies (Q = 45·28, P value for heterogeneity = 0·00001, I 2 = 65 %).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…There were twenty-nine studies reported on TAG (twelve cohort studies, four cross-sectional and thirteen case-control studies) published between 1990 and 2013 and involved a total of 31 546 CRN cases (Tables 1 and 2) (4,6,(8)(9)(10)(16)(17)(18)20,(22)(23)(24)(26)(27)(28)(29)(30)(31)(32) . Nine studies were conducted in the USA (16,18,20,32,35,(37)(38)(39)(40) , one in Sweden (42) , five in Korea (6,9,10,22,27) , two in China (23,30) , eight in Japan (8,24,26,28,29,31,36,43) , one in Austria (41) and three in European countries (4,17,34) <...>…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Nine studies were conducted in the USA (16,18,20,32,35,(37)(38)(39)(40) , one in Sweden (42) , five in Korea (6,9,10,22,27) , two in China (23,30) , eight in Japan (8,24,26,28,29,31,36,43) , one in Austria (41) and three in European countries (4,17,34) (Tables 1 and 2). Pooled analysis showed a significant association between serum TAG and CRN (n 29 studies; summary RR = 1·08; 95 % CI 1·05, 1·12, P < 0·00001; Fig.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Overall analyses on the association of serum lipids and colorectal cancer Eight publications in the present meta-analysis on TC (four cohort and four case-control studies) and risk of CRC were published between 1992 and 2012 and involved a total of 10 979 CRC cases (Table 1) (4,21,22,25,34,38,42,43) . One study (1992) (38) , USA (2011) (17) , (32) , USA (43) , Japan (2010) (26) , Japan was conducted in the USA (38) , one in Sweden (42) , one in Korea (22) , two in Japan (25,43) , one in Finland (21) and two in European countries (4,34) (Table 1).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…One study (1992) (38) , USA (2011) (17) , (32) , USA (43) , Japan (2010) (26) , Japan was conducted in the USA (38) , one in Sweden (42) , one in Korea (22) , two in Japan (25,43) , one in Finland (21) and two in European countries (4,34) (Table 1). Pooled data did not support the association between TC and CRC (RR = 0·95; 95 % CI 0·85, 1·06, P = 0·38).…”

Section: Study Characteristicsmentioning

confidence: 99%

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The association between serum lipids and colorectal neoplasm: a systemic review and meta-analysis

Tian

Wang

et al. 2015

Public Health Nutr.

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Objective: There have been inconsistent results published regarding the relationship between dyslipidaemia and an increased risk of colorectal neoplasia (CRN), including colorectal adenoma (CRA) and colorectal cancer (CRC). We conducted a meta-analysis to explore the relationship between dyslipidaemia and CRN. Design: We identified studies by performing a literature search using PubMed, EMBASE and the Science Citation Index through October 2013. Setting: We analysed thirty-three independent studies reporting the association between CRN and at least one of the selected lipid components, including total cholesterol (TC), TAG, HDL-cholesterol (HDL-C) and LDL-cholesterol (LDL-C). Subjects: CRN cases (n 21 809) were identified. Results: Overall, people with high levels of serum TAG (risk ratio (RR) = 1·08; 95 % CI 1·05, 1·12, P < 0·00001) and LDL-C (RR = 1·07; 95 % CI 1·00, 1·14, P = 0·04) presented an increased prevalence of CRN. Subgroup analyses revealed that high levels of serum TC (RR = 1·04; 95 % CI 1·01, 1·09, P = 0·02), TAG (RR = 1·06; 95 % CI 1·03, 1·10, P = 0·0009) and LDL-C (RR = 1·11; 95 % CI 1·04, 1·19, P = 0·003) increased the risk of CRA but not of CRC. No association between serum HDL-C and risk for CRN (including CRA and CRC) was observed. Conclusions: Both TAG and LDL-C were significantly associated with an increasing prevalence of CRN. High levels of serum TC, TAG and LDL-C were positively associated with CRA but not with CRC. No significant association was observed between levels of serum HDL-C and CRN. Keywords Serum lipids Colorectal adenomaColorectal cancer TAG Meta-analysis Colorectal cancer (CRC) is reported to be the fourth most commonly diagnosed cancer and is the second most common cause of cancer deaths in North America (1) . CRC is believed to arise from colorectal adenoma (CRA) through a sequence from adenoma to adenocarcinoma as a consequence of a limited set of molecular events that largely originate with a relatively benign adenoma that progresses to cancer (2) . Accumulated data indicate that metachronous lesions occur at a rate of 20 to 30 % per year in post-polypectomy patients. The propensity to develop CRA identifies a sizeable subgroup of the population at an enhanced risk for subsequent adenoma formation and colorectal carcinoma. This indicates that identifying risk factors associated with CRN is essential for the reduction of colorectal carcinoma.The positive association between obesity and CRA prevalence demonstrates an underlying dose-response relationship according to BMI (3) . Timely screening of obese patients for CRA is thus recommended. Dyslipidaemia is an important component of metabolic syndrome and is demonstrated to contribute to colorectal tumorigenesis through insulin resistance, oxidative stress and inflammatory † The first three authors contributed equally to this work.

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

See 3 more Smart Citations

The association between serum lipids and colorectal neoplasm: a systemic review and meta-analysis

Tian

Wang

et al. 2015

Public Health Nutr.

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Comparison of some biochemical markers between early‐onset and late‐onset colorectal precancerous lesions: A single‐center retrospective study

Tang

Yang

et al. 2022

Clinical Laboratory Analysis

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Objective Given that the onset of diseases including colorectal cancer precursors is affecting younger individuals and that obesity is an important risk factor for early‐onset, we conducted a study to explore the biochemical profile of differences in serum between early‐onset patients and late‐onset colorectal precancerous lesions. Methods A total of 1447 patients, including 469 early‐onset patients and 978 late‐onset patients, were enrolled from the First Affiliated Hospital of Nanchang University (FAHNU), of which there were 311 sessile serrated adenoma/polyps (SSA/P) and 1136 normal adenomas. The distribution of the included categorical variables was compared via Pearson's chi‐squared test, whereas continuous variables were compared by using the nonparametric Kruskal–Wallis test and anova . Results Compared with late‐onset patients, the levels of total bilirubin and HDL‐C were lower ( p < 0.05), whereas triglyceride and uric acid levels were higher, in early‐onset patients. Interestingly, in the subgroup analysis, triglyceride and uric acid levels remained at higher levels, whereas HDL‐C remained at lower levels, in early‐onset patients than in late‐onset patients. Other characteristics, such as LDL‐C, drinking, γ‐GT, and the N/L ratio, were similar between the two groups. An additional analysis of the association of tumor size with markers showed that lower levels of HDL‐C and higher levels of uric acid were associated with increased tumor size ( p < 0.05). Conclusions Early‐onset CRC precursor cases exhibit higher levels of triglycerides and lower levels of HDL‐C than late‐onset cases. Additionally, levels of HDL‐C are negatively associated with tumor size, whereas uric acid was positively correlated with tumor size.

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Obesity and colorectal adenomatous polyps: A cross-sectional study in Korean adults

Lee

Kwak

Myung

et al. 2013

Obesity

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Objective: This study aimed to examine the association between obesity and the risk of colorectal adenomatous polyps. Design and Methods: The design of this study is a cross-sectional study. A total of 1,574 participants (818 males and 756 females), who had undergone colonoscopy for health examinations at the National Cancer Center hospital in South Korea from February to September 2009, were included in the analysis. Results: The prevalence of colorectal adenomatous polyps was 39.5% in males and 22.6% in females. In multiple logistic regression analysis, obesity (odds ratio [OR] ¼ 1.69, 95% CI ¼ 1.16-2.48) and abdominal obesity (OR ¼ 1.59, 95% CI ¼ 1.13-2.23) were significantly associated with an increased risk of colorectal adenomatous polyps in males, but not in females. In the subgroup analyses by age, obesity (OR ¼ 2.27, 95% CI ¼ 1.32-3.89), and abdominal obesity (OR ¼ 1.76, 95% CI ¼ 1.12-2.76) significantly increased a risk of colorectal adenomatous polyps in males aged <50 years, but not in males aged 50 years. However, interaction terms were not significant between obesity and gender (P ¼ 0.397) and between obesity and age (P ¼ 0.531) in the overall analyses.

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Association of obesity, serum glucose and lipids with the risk of advanced colorectal adenoma and cancer: A case-control study in Korea

Cited by 88 publications

References 23 publications

The association between serum lipids and colorectal neoplasm: a systemic review and meta-analysis

The association between serum lipids and colorectal neoplasm: a systemic review and meta-analysis

Comparison of some biochemical markers between early‐onset and late‐onset colorectal precancerous lesions: A single‐center retrospective study

Obesity and colorectal adenomatous polyps: A cross-sectional study in Korean adults

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