Association of obesity profiles and metabolic health status with liver injury among US adult population in NHANES 1999–2016

Huang, Jing; Gao, Tian; Zhang, Huinan; Wang, Xing

doi:10.1038/s41598-023-43028-7

Cited by 3 publications

(1 citation statement)

References 41 publications

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“…Abdominal obesity and general obesity have been suggested to be a risk factor for liver injury. General obesity has a more significant influence on the association with liver enzyme levels and the prevalence of abnormal liver enzymes than abdominal obesity (Huang et al, 2023).…”

Section: Obesitymentioning

confidence: 99%

Quantum Stem Cell Therapy for Recovery of Liver Disease

Susanti Vinski,

Schroeter,

Hardjo

et al. 2024

JWS

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Chronic liver diseases pose a significant global health challenge, necessitating the development of novel therapeutic strategies for liver regeneration and functional recovery. Mesenchymal stem cells (MSCs) derived from umbilical cord blood have emerged as promising candidates for liver regeneration due to their multipotent differentiation capacity, immunomodulatory properties, and paracrine effects. This study aims to investigate the efficacy, safety, and underlying mechanisms of stem cell therapy in the recovery and regeneration of liver tissue in patients with liver disease. The research method used is a case study where Mesenchymal Stem Cell therapy offers the potential to modify the natural recovery of Liver function using stem cell-based technology. Case studies were carried out on several Vinski Regenerative Center clinic patients. This review explores the therapeutic potential of umbilical cord blood-derived MSCs in promoting the recovery of liver function in preclinical and clinical settings. We discuss the mechanisms by which MSCs facilitate liver regeneration, including their ability to differentiate into hepatocyte-like cells, modulate immune responses, and secrete trophic factors that promote tissue repair. Preclinical studies demonstrate the efficacy of umbilical cord blood-derived MSCs in ameliorating liver injury, reducing fibrosis, and improving overall liver function. Challenges such as optimal dosing, timing of administration, and long-term monitoring remain to be addressed. Nevertheless, MSCs from umbilical cord blood represent a promising therapeutic approach for liver regeneration and hold great potential for improving outcomes in patients with liver disease.

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Section: Obesitymentioning

confidence: 99%

Quantum Stem Cell Therapy for Recovery of Liver Disease

Susanti Vinski,

Schroeter,

Hardjo

et al. 2024

JWS

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Association between SII and markers of liver injury: A cross-sectional study from the NHANES (2017–2020)

Zhang,

Qin

2024

PLoS ONE

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Introduction A novel indicator of inflammation is the systemic immune-inflammation index (SII), and liver dysfunction is linked to the advancement of inflammation. In light of this, this study aims to look into any potential connections between SII and markers of liver injury. Methods A cross-sectional study was conducted using the National Health and Nutrition Examination (NHANES) dataset for 2017–2020. The linear relationship between SII and markers of liver injury was examined using multiple linear regression models. Examining threshold effects and fitted smoothed curves were utilized to describe nonlinear connections. Results A total of 8213 adults aged 18–80 years participated in this population-based study. In the fully adjusted model, SII maintained a negative association with ALT(β = -0.003, 95%CI:-0.005, -0.002, P<0.00001), AST(β = -0.004, 95% CI:-0.005, -0.002, P<0.00001), and GGT(β = -0.004, 95% CI:-0.007, -0.000, P = 0.03791) and a positive association with ALP (β = 0.005, 95% CI:0.003, 0.007, P<0.00001). In subgroup analyses, it was found that SII remained negatively correlated with ALT, AST and GGT in gender, age and body mass index. SII was positively correlated with ALP at BMI≥25(kg/m2)(β = 0.005, 95% CI:0.003, 0.008, P = 0.00001), and was negatively correlated with ALT(β = -0.004, 95% CI:-0.005, -0.002, P<0.00001), AST(β = -0.004, 95% CI:-0.005, -0.003, P<0.00001) and GGT(β = -0.004, 95% CI:-0.008, -0.000, P = 0.02703) at BMI≥25, whereas no significant correlation was observed at BMI<25 (all P-values>0.05). Furthermore, the association between SII and markers of liver injury was nonlinear. By using a two-stage linear regression model for analysis, a U-shaped relationship was found to exist between SII and ALT with a turning point of 818.40(1,000 cells/μl). The inflection points of SII with AST and GGT were 451.20 (1,000 cells/μl) and 443.33 (1,000 cells/μl), respectively, and no significant inflection point with ALP was observed. Interaction tests demonstrated that SII correlation with ALT, AST, ALP, and GGT was not significantly different between strata (all p for interaction>0.05). Conclusions The research findings suggested that there was a negative correlation between SII and ALT, AST and GGT, and a positive correlation with ALP. However, larger prospective investigations are still greatly needed to confirm the findings.

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Elevated Alanine Transaminase-to-Platelet Index (APRI) Is Associated with Obesity and Distinct Forms of Dyslipidemia: A Retrospective Cross-Sectional Study

Alshuweishi,

Alfayez,

Almufarrih

et al. 2024

JCM

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Background: Obesity is a pathological condition and a major risk factor for dyslipidemia, type 2 diabetes, and non-alcoholic fatty liver disease. Recent research highlighted the association of non-invasive serum markers with these conditions but the clinical utility of ALT APRI in obesity and its relationship with dyslipidemia remain unexplored. Methods: We examined the association of ALT APRI in 165 non-diabetic adults stratified by BMI and serum lipid parameters. Results: Obese subjects had significantly higher APRI than lean subjects, with an area under the curve (AUC) of 0.65 (p = 0.019). Medians of APRI were significantly increased in subjects with high TG, TG/HDL, TC/HDL, and LDL/HDL and low HDL. Notably, all lipid parameters and ratios were significantly elevated in the highest APRI tertile, compared with patients in the lowest tertile. APRI was weakly yet significantly correlated with BMI (R2 = 0.032, p = 0.022), HDL (R2 = 0.071), TG/HDL (R2 = 0.031), TC/HDL (R2 = 0.063), LDL/HDL (R2 = 0.072), and TyG index (R2 = 0.081). While APRI only showed a discriminating capacity for HDL (AUC: 0.69, p = 0.003), TG/HDL (AUC: 0.63, p = 0.020), LDL/HDL (AUC: 0.68, p < 0.001), and TyG index (AUC: 0.65, p = 0.037), the highest diagnostic performance of APRI was observed with TC/HDL (AUC: 0.74, p < 0.001). Additionally, APRI was a risk factor for high TG (OR: 1.6, p = 0.028), low HDL (OR: 2.7, p = 0.0002), high TG/HDL (OR: 1.94, p = 0.0011), high TC/HDL (OR: 2.3, p < 0.0001), high LDL/HDL (OR: 2.2, p = 0.0001), and high TyG index (OR: 2.1, p = 0.008). Conclusions: Our findings argue for the role of APRI as a potential marker for obesity and dyslipidemia, which requires further confirmation in longitudinal studies.

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Association of obesity profiles and metabolic health status with liver injury among US adult population in NHANES 1999–2016

Cited by 3 publications

References 41 publications

Quantum Stem Cell Therapy for Recovery of Liver Disease

Quantum Stem Cell Therapy for Recovery of Liver Disease

Association between SII and markers of liver injury: A cross-sectional study from the NHANES (2017–2020)

Elevated Alanine Transaminase-to-Platelet Index (APRI) Is Associated with Obesity and Distinct Forms of Dyslipidemia: A Retrospective Cross-Sectional Study

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