Association of Obesity and Diabetes With Prostate Cancer Risk Groups in a Multiethnic Population

Zhu, Denzel; Toker, Michelle; Shyr, William; Fram, Ethan; Watts, Kara; Agalliu, Ilir

doi:10.1016/j.clgc.2022.01.016

Cited by 10 publications

(9 citation statements)

References 29 publications

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“…A total of 15 studies were included in this review, with 1,080,106 diabetic patients who developed different types of cancers. Seven studies were conducted in the USA [13][14][15][16][17][18][19], two in China [20,21], one in Canada [22], one in the Australia [23], one in Lithuania [24], one in Poland [25] one in Finland [26] and one in the UK [27]. Regarding the studies' designs; Eight studies were retrospective in nature [13,16,19,20,22,[24][25][26], four were prospective [14,17,23,27], and two were case-control studies [15,21].…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…Seven studies were conducted in the USA [13][14][15][16][17][18][19], two in China [20,21], one in Canada [22], one in the Australia [23], one in Lithuania [24], one in Poland [25] one in Finland [26] and one in the UK [27]. Regarding the studies' designs; Eight studies were retrospective in nature [13,16,19,20,22,[24][25][26], four were prospective [14,17,23,27], and two were case-control studies [15,21]. Seven studies included patients with T2DM [16][17][18][19][23][24][25], two studies included patients with T1DM [26,27], and six studies included patients with both type1 and type2 DM [13][14][15][20][21][22].…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…Regarding the studies' designs; Eight studies were retrospective in nature [13,16,19,20,22,[24][25][26], four were prospective [14,17,23,27], and two were case-control studies [15,21]. Seven studies included patients with T2DM [16][17][18][19][23][24][25], two studies included patients with T1DM [26,27], and six studies included patients with both type1 and type2 DM [13][14][15][20][21][22]. Lung cancer was reported in two studies [13,19], prostate cancer [16,22], thyroid cancer [21,26], colorectal cancer [18,25], different cancer types [14,27], biliary tract cancer (BTC) [20], breast cancer [15], pancreatic cancer [23], endometrial cancer [24], and bladder cancer [17].…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…Seven studies included patients with T2DM [16][17][18][19][23][24][25], two studies included patients with T1DM [26,27], and six studies included patients with both type1 and type2 DM [13][14][15][20][21][22]. Lung cancer was reported in two studies [13,19], prostate cancer [16,22], thyroid cancer [21,26], colorectal cancer [18,25], different cancer types [14,27], biliary tract cancer (BTC) [20], breast cancer [15], pancreatic cancer [23], endometrial cancer [24], and bladder cancer [17]. Most of our included studies reported that DM increases the risk of cancer development; however, two studies reported that DM was associated with a lower risk of prostate cancer [14,22].…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

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Diabetes Mellitus as a Risk Factor for Different Types of Cancers: A Systematic Review

Alharbi¹

2022

Clin Cancer Investig J

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Diabetes mellitus (DM) is a common endocrine condition that affects people all over the world. Numerous clinical research has looked into the relationship between diabetes and cancer and how it may be caused. This review investigates the recently published literature regarding the risk of the development of cancer in patients with DM. PubMed, Web of Science, Science Direct, EBSCO, and Cochrane library were searched. Study articles were screened by title and abstract using Rayyan QCRI then a full-text assessment was implemented. Fifteen studies were included, with 1,080,106 diabetic patients who developed different types of cancers. Most of our included studies reported that DM increases the risk of cancer development; however, it is reported that DM was related to a lower risk of prostate cancer. This review revealed a potential link between cancer and diabetes. However, most of the studies' findings are ambiguous and contradictory, necessitating further investigation to establish the relationship between diabetes and cancer.

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Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

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Diabetes Mellitus as a Risk Factor for Different Types of Cancers: A Systematic Review

Alharbi¹

2022

Clin Cancer Investig J

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“…During the past decades, obesity has become a global public health problem. It was reported that obesity was not only a critical risk factor for metabolic diseases but also associated with cancer and reproductive system diseases significantly [ 1 , 2 ]. Obesity can be divided into two types clinically according to the etiology: simple and secondary.…”

Section: Introductionmentioning

confidence: 99%

Study on the Effect and Mechanism of Huaji Jianpi Decoction on Simple Obesity

Zhu

Zhang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. As the major type of obesity in clinical, simple obesity has gained increasing attention in recent years. Depending on the etiology and pathogenesis of simple obesity and combined with clinical practice experience, Huaji Jianpi decoction (HJJPD) was established to invigorate the spleen and eliminate dampness; however, the underlying molecular mechanism is yet unclear. Materials and Methods. A simple obesity mouse model was established by feeding a high-fat diet to the animals, and the related indexes were analyzed. The mice were divided into the normal, positive control (orlistat), and HJJPD high-dose, medium-dose, and low-dose groups. After 6 weeks of administration, the curative effect of HJJPD was observed. Simple obesity is associated with leptin resistance. The leptin signal transduction pathways mainly include the JAK2-STAT3, AMPK-ACC, LepRb-IRS-PI3K-PDE3B-cAMP, and LepRb-SHP2-MAPKs (ERK1/2) pathways. Therefore, the networks of HJJPD acting on these four pathway-related targets were constructed using the network pharmacology method, and the key nodes were identified. Results. After 6 weeks of drug intervention, we found a good therapeutic effect of HJJPD on simple obesity in the mouse model. The biological network analysis showed that HJJPD plays a role in treating leptin resistance in simple obesity by acting on multiple targets in the JAK2-STAT3 pathway via various components. Also, HJJPD can improve leptin resistance in mice by enhancing the binding force of LEP and LEPRB and activating the LEP-mediated JAK2-STAT3 signaling pathway. Conclusion. In this study, animal experiments, network pharmacology, and molecular biology were combined to establish a mouse model of simple obesity, confirm the role of HJJPD in the treatment of simple obesity, and preliminarily reveal the related mechanism. Relevant research results will provide a basis for the treatment of simple obesity and the drug discovery.

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Health-aware food recommendation system with dual attention in heterogeneous graphs

Forouzandeh,

Rostami,

Berahmand

et al. 2024

Computers in Biology and Medicine

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Association of Obesity and Diabetes With Prostate Cancer Risk Groups in a Multiethnic Population

Cited by 10 publications

References 29 publications

Diabetes Mellitus as a Risk Factor for Different Types of Cancers: A Systematic Review

Diabetes Mellitus as a Risk Factor for Different Types of Cancers: A Systematic Review

Study on the Effect and Mechanism of Huaji Jianpi Decoction on Simple Obesity

Health-aware food recommendation system with dual attention in heterogeneous graphs

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