Association of Obesity and Central Fat Distribution With Carotid Artery Wall Thickening in Middle-Aged Women

Michele, Mario De; Panico, Salvatore; Celentano, Egidio; Ciardullo, Anna V.; Galasso, Rocco; Sacchetti, Lucia; Zarrilli, Federica; Bond, M. Gene; Rubba, P.

doi:10.1161/01.str.0000038989.90931.be

Cited by 178 publications

(121 citation statements)

References 43 publications

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“…4 A graded and independent association of WHR and BMI with carotid IMT was found in a cross-sectional study in middle-aged women. 12 WHR and BMI were also directly associated with carotid IMT in a crosssectional study among Japanese men aged 20-78 years. 23 Some studies have not shown an independent association of BMI 14 or measures of abdominal obesity 13 with carotid IMT.…”

Section: Discussionmentioning

confidence: 94%

“…A number of previous studies have evaluated the relationship between obesity and CVD, but only a few have focused on the association between abdominal obesity and preclinical atherosclerosis. 4,12 Few, if any, studies have assessed the association between hip circumference and atherosclerosis. Change in carotid IMT, as assessed by ultrasonography, has been validated as a vascular marker of atherosclerosis progression.…”

Section: Discussionmentioning

confidence: 99%

“…4,12 Other studies in middle-aged or older persons have not shown such associations. 13,14 In elderly individuals, intra-abdominal fat appears to be an independent risk factor for myocardial infarction 15 and a large waist circumference for mortality.…”

Section: Introductionmentioning

confidence: 91%

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Association of waist and hip circumference with 12-year progression of carotid intima-media thickness in elderly women

et al. 2007

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Objective: To test the hypothesis that waist and hip circumferences together provide additional information on the progression of preclinical atherosclerosis beyond either of them alone in elderly women. Design: A 12-year follow-up study. Subjects: A population-based sample of 102 women 60-70 years of age at baseline. Measurements: Waist and hip circumferences and body mass index (BMI) were assessed and carotid intima-media thickness (IMT) was quantified noninvasively by ultrasonography.Results: There was a significant increase in the 12-year carotid IMT progression across the thirds of waist circumference (0.080, 0.277, 0.279 mm, P ¼ 0.02 for difference) and hip circumference (0.030, 0.342, 0.260 mm, P ¼ 0.001 for difference) adjusted for conventional risk factors (age, smoking, systolic blood pressure, serum low-density lipoprotein and high-density lipoprotein cholesterol, blood glucose). The association of waist circumference with IMT progression was not significant after further adjustment for hip circumference or BMI. Further adjustment for waist circumference and BMI did not change the association of hip circumference with IMT progression. The IMT progression was greatest in women with waist circumference 483 cm and hip circumference p98 cm adjusted for conventional risk factors (P ¼ 0.003 for interaction). Conclusion: Not only waist circumference but also hip circumference is associated with the progression of carotid atherosclerosis during 12 years in elderly women. Women with both a larger waist circumference and a smaller hip circumference had the greatest progression of carotid atherosclerosis.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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Association of waist and hip circumference with 12-year progression of carotid intima-media thickness in elderly women

et al. 2007

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“…35,36 CIMT is correlated with adult BMI 37,38 and recent studies have suggested that it is also associated with childhood BMI. However, this systematic review only found two studies, which show a positive independent association between childhood BMI Childhood obesity and adult CVD LJ Lloyd et al and adult CIMT.…”

Section: Carotid-intima Thicknessmentioning

confidence: 99%

Childhood obesity and adult cardiovascular disease risk: a systematic review

2009

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Background: Although the relationship between adult obesity and cardiovascular disease (CVD) has been shown, the relationship with childhood obesity remains unclear. Given the evidence of tracking of body mass index (BMI) from childhood to adulthood, this systematic review investigated the independent relationship between childhood BMI and adult CVD risk. Objective: To investigate the association between childhood BMI and adult CVD risk, and whether the associations observed are independent of adult BMI. Design: Electronic databases were searched from inception until July 2008 for studies investigating the association between childhood BMI and adult CVD risk. Two investigators independently reviewed studies for eligibility according to inclusion/ exclusion criteria, extracted the data and assessed study quality using the Newcastle-Ottawa Scale. Results: Positive associations between childhood BMI and adult blood pressure or carotid intima-media thickness were generally attenuated once adjusted for adult BMI. Associations between childhood BMI and CVD morbidity/mortality had not been adjusted and do not provide evidence of an independent relationship. Negative associations between childhood BMI and blood pressure were observed in several adjusted data sets. Conclusions: Little evidence was found to suggest that childhood obesity is an independent risk factor for CVD risk. Instead, the data suggest that relationships observed are dependent on the tracking of BMI from childhood to adulthood. Importantly, evidence suggests that risk of raised blood pressure is highest in those who are at the lower end of the BMI scale in childhood and overweight in adulthood. The findings challenge the widely accepted view that the presence of childhood obesity is an independent risk factor for CVD and that this period should be a priority for public health intervention. Although interventions during childhood may be important in prevention of adult obesity, it is important to avoid the potential for negative consequences when the timing coincides with critical stages of neurological, behavioural and physical development.

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“…È stata dimostrata una correlazione diretta tra IMT e rischio di infarto del miocardio e ictus in pazienti senza una storia di malattia vascolare [56], e diverse alterazioni metaboliche, come l'obesità [57], l'insulino-resistenza [58], l'iperandrogenismo [59], sono state largamente accettate come fattori di rischio per l'incremento dell'IMT.…”

Section: Struttura E Funzione Endoteliali Nella Pcosunclassified

The polycystic ovary syndrome: an example of obesity-related cardiovascular complication affecting young women

Orio

Cascella

Giallauria

et al. 2016

Monaldi Arch Chest Dis

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RASSEGNA IntroduzioneLa sindrome dell'ovaio policistico (PCOS) è una tra le più comuni patologie endocrine delle donne, essendone affetto il 5-10% delle donne in età riproduttiva [1,2].La PCOS è diagnosticata in presenza di due tra i tre criteri seguenti: 1. ovaie policistiche all'ecografia pelvica 2. oligo-anovulazione 3. evidenza clinica o biochimica di iperandrogenismo (Rottherdam ESHRE-ASRM 2003) [3]. La PCOS non è solo una delle cause principali di infertilità nelle donne, ma è considerata anche una vera e propria sindrome plurimetabolica [2,4,5]: obesità [6], insulino-resistenza [7], dislipidemia [8], alterazione del sistema fibrinolitico [9], sono le conseguenze metaboliche spesso evidenti in questa sindrome.Inoltre, la PCOS è associata a rischi per la salute a lungo termine, inclusi il diabete mellito [10] e la CDV (Malattia Cardiovascolare) [11][12][13][14][15].In particolare l'insulino-resistenza, l'iperandrogenismo e la dislipidemia sono probabilmente tra i maggiori fattori di rischio per l'incidenza della CDV nella PCOS. Tali fattori di rischio cardiovascolare sono spesso evidenti in giovane età, suggerendo che le donne con PCOS, rappresentano un numeroso gruppo di donne in cui è aumentato il rischio di sviluppo precoce di CDV, anche se ciò non è attualmente dimostrato [16].È stato riportato che il rischio di malattia coronarica e di infarto del miocardio è aumentato in pazienti con PCOS rispetto a donne con cicli regolari [11], anche se la mortalità dovuta a malattia circolatoria non sembra essere incrementata [17].Recenti studi hanno dimostrato un incremento della prevalenza di CDV in donne con PCOS [14][15][16][17]. Infatti nella PCOS è stata dimostrata disfunzione endoteliale [18) e diastolica [19] ed è stata associata sia ad elevati livelli di androgeni che ad insulino-resistenza.Di recente, insieme ai classici fattori di rischio CV, come i livelli di colesterolo totale e i livelli di lipoproteine ad alta densità per il colesterolo (HDL-C), l'obesità, l'omocisteina e l'ipertrofia ventricolare sinistra si sono dimostrati essere associati, indipendentemente, ad un incremento del rischio CV [20].

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Association of Obesity and Central Fat Distribution With Carotid Artery Wall Thickening in Middle-Aged Women

Cited by 178 publications

References 43 publications

Association of waist and hip circumference with 12-year progression of carotid intima-media thickness in elderly women

Association of waist and hip circumference with 12-year progression of carotid intima-media thickness in elderly women

Childhood obesity and adult cardiovascular disease risk: a systematic review

The polycystic ovary syndrome: an example of obesity-related cardiovascular complication affecting young women

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