Association of NPSR1 rs324981 polymorphism and treatment response to antidepressants in Chinese Han population with generalized anxiety disorder

He, Qianqian; Shen, Zhongxia; Ren, Lie; Wang, Xing; Qian, Mincai; Zhu, Jiang; Shen, Xinhua

doi:10.1016/j.bbrc.2018.08.145

Cited by 6 publications

(2 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In line with this, increased sensitivity to PD was observed in adult T-allele carrier Caucasian patients diagnosed with PD or another anxiety disorder (i.e., generalized anxiety disorder (GAD), social phobia, agoraphobia or phobia not otherwise specified) [ 76 ]. Similar to observations in PD, a trend for an underrepresentation of the AA genotype was observed in adult Asian patients with GAD compared to healthy controls [ 77 ]. In a recent study, an increased risk in developing PTSD following the Balkan war was revealed in carriers of the TT genotype [ 78 ].…”

Section: Alterations In the Nps/npsr1 System In Stress-related Disorderssupporting

confidence: 76%

Role of the Neuropeptide S System in Emotionality, Stress Responsiveness and Addiction-Like Behaviours in Rodents: Relevance to Stress-Related Disorders

Tobinski

Rappeneau

2021

Pharmaceuticals

View full text Add to dashboard Cite

The neuropeptide S (NPS) and its receptor (NPSR1) have been extensively studied over the last two decades for their roles in locomotion, arousal/wakefulness and anxiety-related and fear-related behaviours in rodents. However, the possible implications of the NPS/NPSR1 system, especially those of the single nucleotide polymorphism (SNP) rs324981, in stress-related disorders and substance abuse in humans remain unclear. This is possibly due to the fact that preclinical and clinical research studies have remained separated, and a comprehensive description of the role of the NPS/NPSR1 system in stress-relevant and reward-relevant endpoints in humans and rodents is lacking. In this review, we describe the role of the NPS/NPSR1 system in emotionality, stress responsiveness and addiction-like behaviour in rodents. We also summarize the alterations in the NPS/NPSR1 system in individuals with stress-related disorders, as well as the impact of the SNP rs324981 on emotion, stress responses and neural activation in healthy individuals. Moreover, we discuss the therapeutic potential and possible caveats of targeting the NPS/NPSR1 system for the treatment of stress-related disorders. The primary goal of this review is to highlight the importance of studying some rodent behavioural readouts modulated by the NPS/NPSR1 system and relevant to stress-related disorders.

show abstract

Section: Alterations In the Nps/npsr1 System In Stress-related Disorderssupporting

confidence: 76%

Role of the Neuropeptide S System in Emotionality, Stress Responsiveness and Addiction-Like Behaviours in Rodents: Relevance to Stress-Related Disorders

Tobinski

Rappeneau

2021

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

“…[ 21 ] Previous research proved that the occurrence of GAD is related to the polymorphism of several genes, such as rs4680 of catechol-O-methyltransferase gene, [ 22 ] C677T of methylenetetrahydrofolate reductase gene [ 23 ] rs324981 of NPSR1 gene. [ 24 ] These studies indicated that alteration of gene polymorphism might play an important role in the development of GAD. Therefore, a deep understanding of the relationship between gene polymorphism and GAD development is important for elucidating the mechanism of this disease.…”

Section: Discussionmentioning

confidence: 99%

Relationship between intestinal flora, inflammation, BDNF gene polymorphism and generalized anxiety disorder: A clinical investigation

et al. 2022

View full text Add to dashboard Cite

Introduction: Understanding factors related to generalized anxiety disorder pathogenesis is critical for elucidating the mechanism and preventing its establishment. Intestinal flora and hereditary factors such as brain-derived neurotrophic factor (BDNF) gene polymorphism may have a role in the development of generalized anxiety disorder. This work explored the relationship between intestinal flora, inflammatory changes and BDNF gene polymorphisms and the occurrence of generalized anxiety disorder. Methods: Forty-eight patients with generalized anxiety disorder and 57 healthy people were included in the study. As the disease group and control group, the polymorphisms of rs10767664 and rs7124442 of the BDNF gene, differences in the distribution of intestinal flora, and changes in inflammatory and immune indicators were analyzed. Results: The distribution of BDNF gene alleles, genotypes and haplotypes in the disease group were different from those in the control group. The levels of TNF-α (P = .000), interleukin-4 (P = .000), interleukin-10 (P = .043) and IgG (P = .008) in patients with generalized anxiety disorder in the disease group were different from those in the control group. The distribution of gut microbes in patients with generalized anxiety disorder in the disease group was different from that in the control group. Conclusion: The onset of generalized anxiety disorder is related to BDNF gene polymorphism, and is accompanied by changes in intestinal flora and inflammatory immune status in the body.

show abstract

Association between 5-HT1B gene polymorphisms and generalized anxiety disorder in the Han Chinese population

Wang,

Su,

Shen

et al. 2024

Human Gene

View full text Add to dashboard Cite

Association of NPSR1 rs324981 polymorphism and treatment response to antidepressants in Chinese Han population with generalized anxiety disorder

Cited by 6 publications

References 34 publications

Role of the Neuropeptide S System in Emotionality, Stress Responsiveness and Addiction-Like Behaviours in Rodents: Relevance to Stress-Related Disorders

Role of the Neuropeptide S System in Emotionality, Stress Responsiveness and Addiction-Like Behaviours in Rodents: Relevance to Stress-Related Disorders

Relationship between intestinal flora, inflammation, BDNF gene polymorphism and generalized anxiety disorder: A clinical investigation

Association between 5-HT1B gene polymorphisms and generalized anxiety disorder in the Han Chinese population

Contact Info

Product

Resources

About