Association of Novel Loci With Keratoconus Susceptibility in a Chinese Genome-Wide Association Study
Liyan Xu,
Xiaodong Zheng,
Shanshan Yin
et al.
Abstract:Purpose
Keratoconus (KC) is a progressive corneal disease that can lead to corneal blindness if not properly managed. The purpose of this study was to identify genetic associations with KC in China and to investigate whether these genetic variants are associated with corneal thickness and corneal curvature in KC cases.
Methods
A genome-wide association study was conducted on 853 patients with KC and 6248 controls. The KC cases were genotyped with the Illumina Infinium H… Show more
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