Association of Non-High-Density Lipoprotein Cholesterol with Low-Density Lipoprotein Cholesterol in Korean Children and Adolescents: The Korean National Health and Nutrition Examination Surveys 2008 - 2014

Abstract

Background: The aim of this study was to identify the association between non-high-density lipoprotein cholesterol (non-HDL-C) and low-density-lipoprotein cholesterol (LDL-C) according to age and gender in apparently healthy Korean children and adolescents.Methods: A total of 6,255 subjects aged 10-19 years from the 2008-2014 Korean National Health and Nutrition Examination Survey were analyzed. Serum non-HDL-C, LDL-C, and their association were evaluated according to age and gender. Results:The means of the 75th percentile and 95th percentile concentrations for non-HDL-C were 117.0 mg/dL and 148.0 mg/dL in males, respectively, and 121.0 mg/dL and 151.0 mg/dL in females, respectively. The means of the 75th percentile and 95th percentile concentrations for LDL-C were 99.2 mg/dL and 125.0 mg/dL in males, respectively, and 102.8 mg/dL and 128.9 mg/dL in females, respectively. The mean age-and gender-specific difference between non-HDL-C and LDL-C was approximately 15-20 mg/dL in all age groups. The mean difference between non-HDL-C and LDL-C was 16.8 mg/dL in males and 17.0 mg/dL in females (P=0.370). In the subgroup analyses, the mean difference between non-HDL-C and LDL-C was higher in boys and girls with TG levels ≥ 150 mg/dL than in those with TG levels <150 mg/dL (39.93 mg/dL vs 14.50 mg/dL, P < 0.001 in males and 39.28 mg / dL vs 15.13 mg/dL, P<0.001 in females). Conclusions:In apparently healthy Korean children and adolescents, the mean difference between non-HDL-C and LDL-C was approximately 20 mg/dL among both genders.