Association of neutrophil / lymphocyte ratio, platelet /lymphocyte ratio and brachial retinal vein occlusion

Atum, Mahmut; Yuvacı, İsa; Yaylacı, Selçuk; Genç, Ahmed Bilal; Uçak, Turgay; Bozkurt, Erdinç; Alagöz, Gürsoy

doi:10.5455/annalsmedres.2019.07.365

Cited by 3 publications

(12 citation statements)

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“…Atum et al. (2019) and Sahin et al. (2020) reported odds ratios of 1.00 (95% CI 1.00–1.01, p = 0.116) and 1.02 (95% CI 1.01–1.03, p = 0.002), respectively.…”

Section: Resultsmentioning

confidence: 99%

“…All studies used fundus examination criteria for RVO diagnosis; in addition, three studies reported use of fluorescein angiography for RVO diagnosis (Atum et al. 2019; Kurtul et al. 2020; Pinna et al.…”

Section: Resultsmentioning

confidence: 99%

“…Two studies (Atum et al. 2019; Sahin et al. 2020) performed logistic regression analysis evaluating elevated PLR as an independent predictor of RVO.…”

Section: Resultsmentioning

confidence: 99%

“…(Atum et al. 2019) performed logistic regression analysis evaluating elevated PLR as an independent predictor of BRVO, reporting an odds ratio of 1.00 (95% CI 1.00–1.01, p = 0.116). Two studies (Atum et al.…”

Section: Resultsmentioning

confidence: 99%

“…Two studies (Atum et al. 2019; Zhu & Liu 2019) performed ROC analysis to quantify the ability of PLR to differ between people with and without BRVO both sensitively and specifically (Table 3).…”

Section: Resultsmentioning

confidence: 99%

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The association of neutrophil–lymphocyte ratio and platelet–lymphocyte ratio with retinal vein occlusion: a systematic review and meta‐analysis

Liu

Perry

Penny-Dimri

et al. 2021

Acta Ophthalmologica

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The neutrophil–lymphocyte ratio (NLR) and platelet–lymphocyte ratio (PLR) are emerging haematological inflammatory biomarkers. However, their significance in retinal vein occlusion (RVO) and its subtypes, branch and central RVO (BRVO and CRVO, respectively), is uncertain. This systematic review and meta‐analysis aimed to clarify the association of NLR and PLR with RVO. We searched MEDLINE (Ovid), EMBASE (Ovid) and the Cochrane Library for studies investigating the association of NLR and PLR with RVO from inception to 2 December 2020. We used random‐effects inverse‐variance modelling to generate pooled effect measures. We used bivariate Bayesian modelling to meta‐analyse the ability of NLR and PLR to differ between individuals with and without RVO and performed meta‐regression and sensitivity analyses to explore inter‐study heterogeneity. Eight studies published encompassing 1059 patients were included for analysis. Both NLR and PLR were significantly elevated in RVO, with pooled mean differences of 0.63 (95% confidence interval (CI) 0.31–0.95) and 21.49 (95% CI 10.03–32.95), respectively. The pooled sensitivity, specificity and area under the Bayesian summary receiver operating characteristic curve were, respectively, 0.629 (95% credible interval (CrI) 0.284–0.872), 0.731 (95% CrI 0.373–0.934) and 0.688 (95% CrI 0.358–0.872) for NLR; and 0.645 (95% CrI 0.456–0.779), 0.616 (95% CrI 0.428–0.761) and 0.621 (95% CrI 0.452–0.741) for PLR. Mean and variability of age and diabetes mellitus prevalence partially explained between‐study heterogeneity. NLR and PLR are significantly elevated in RVO. Future research is needed to investigate the potential prognostic value and independence of these findings.

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“…Atum et al. (2019) and Sahin et al. (2020) reported odds ratios of 1.00 (95% CI 1.00–1.01, p = 0.116) and 1.02 (95% CI 1.01–1.03, p = 0.002), respectively.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Two studies (Atum et al. 2019; Sahin et al. 2020) performed logistic regression analysis evaluating elevated PLR as an independent predictor of RVO.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

The association of neutrophil–lymphocyte ratio and platelet–lymphocyte ratio with retinal vein occlusion: a systematic review and meta‐analysis

Liu

Perry

Penny-Dimri

et al. 2021

Acta Ophthalmologica

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Association Between Platelet Indices and Retinal Vein Occlusion

Liu

Perry

Edwards

2021

Retina

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Purpose: Platelet count, mean platelet volume, platelet distribution width, and plateletcrit are standard indices of platelet activation that have been studied in retinal vein occlusion (RVO) and its subtypes: branch retinal vein occlusion and central retinal vein occlusion. This systematic review and meta-analysis aimed to assess the association between these platelet parameters and RVO. Methods: We searched for studies investigating the association between these platelet indices and RVO in multiple online databases from inception to August 2020. Mean differences and the associated confidence intervals were obtained and calculated for each included study and pooled using random-effects inverse variance modeling. Meta-regression was used to explore interstudy and intrastudy heterogeneity. Results: Thousand three hundred and twenty-five unique studies were screened, from which 24 studies encompassing 2,718 patients were included. Mean platelet volume and platelet distribution width were significantly elevated in RVO, with pooled mean differences of 0.45 fL (95% CI 0.24–0.66, P < 0.0001) and 1.43% (95% CI 0.57–2.29, P = 0.0011), respectively. Platelet count and plateletcrit were not significantly associated with RVO. Mean platelet volume was also independently elevated in branch retinal vein occlusion and central retinal vein occlusion. Conclusion: Mean platelet volume and platelet distribution width are significantly elevated in RVO. Further research is required to explore the independence and potential prognostic significance of these associations.

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Platelet-Derived Procoagulant Microvesicles Are Elevated in Patients with Retinal Vein Occlusion (RVO)

Marcinkowska

Wolska

Luzak

et al. 2022

JCM

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The etiopathogenesis of retinal vein occlusion (RVO) is multifactorial, and the contribution of platelets to RVO development has not been fully elucidated. We aimed to analyze platelet function in RVO patients (n = 35) and controls (n = 35). We found a higher (p < 0.05) level of soluble P-selectin in RVO group vs. controls. Additionally, in RVO patients, the concentration of platelet-derived microvesicles was higher (p < 0.05), and the difference between groups was deeper for the fraction of platelet-derived microvesicles with the procoagulant phenotype (p < 0.0001) and for overall procoagulant microvesicles level (p < 0.0001). The results were similar for the total RVO group and for both RVO types (central- and branched-retinal vein occlusion). We did not find differences in simple platelet parameters (platelet count, mean platelet volume, platelet distribution width, platecrit, reticulated platelets) and inflammatory markers (platelet-lymphocyte ratio, neutrophil-lymphocyte ratio). Similarly, no differences were found for platelet aggregation-stimulated byadenosine diphosphate; collagen; arachidonic acid; and in multiparametric flow cytometry evaluation of P-selectin, PAC-1, and fibrinogen binding for both unstimulated and adenosine diphosphate-, collagen-, and thrombin receptor activating peptide-stimulated platelets. Our results suggest that platelets can contribute to developing RVO by enhancing procoagulant activity through providing a procoagulation surface via platelet-derived microvesicles. The direct role of platelets’ hyperreactivity in developing RVO is less apparent, which is consistent with the complexity and multifactorial background of this disorder.

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Association of neutrophil / lymphocyte ratio, platelet /lymphocyte ratio and brachial retinal vein occlusion

Cited by 3 publications

References 0 publications

The association of neutrophil–lymphocyte ratio and platelet–lymphocyte ratio with retinal vein occlusion: a systematic review and meta‐analysis

The association of neutrophil–lymphocyte ratio and platelet–lymphocyte ratio with retinal vein occlusion: a systematic review and meta‐analysis

Association Between Platelet Indices and Retinal Vein Occlusion

Platelet-Derived Procoagulant Microvesicles Are Elevated in Patients with Retinal Vein Occlusion (RVO)

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