Association of neurotrophins, inflammation and stress with suicide risk in young adults

Priya, P. Kaviya; Rajappa, Medha; Kattimani, Shivanand; Mohanraj, Palani Selvam; Revathy, G.

doi:10.1016/j.cca.2016.03.019

Cited by 55 publications

(24 citation statements)

References 25 publications

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“…As exclusion criteria: (1) studies lacking the standard derivation of the mean BDNF levels were excluded from the analysis (Grah et al., ; Mansur et al., ; Priya et al., ). We contacted the corresponding authors to obtain the standard deviation and missing data.…”

Section: Methodsmentioning

confidence: 99%

“…Biomarkers, substances used as indicators of a biological state, represent a useful tool in the diagnosis and prediction of suicide behavior (Le‐Niculescu et al., ; Strimbu & Tavel, ). One of the main biomarkers proposed in association studies with suicide attempted and suicide is a neurotrophin named brain‐derived neurotrophic factor (BDNF; Grah et al., ; Priya, Rajappa, Kattimani, Mohanraj, & Revathy, ).…”

Section: Introductionmentioning

confidence: 99%

“…Of the BDNF present in the circulation, more than a half is originated from brain structures (Rasmussen et al., ). Recently, BDNF has been implicated as a possible biomarker for psychiatric diseases such as schizophrenia, bipolar disorder and major depression, given that BDNF levels are lower in these patients than in healthy subjects (Castren & Kojima, ; Eisen et al., ; Grah et al., ; Hashimoto, ; Kim et al., ; Lee & Kim, ; Priya et al., ). Dwivedi et al.…”

Section: Introductionmentioning

confidence: 99%

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Decrease in brain‐derived neurotrophic factor at plasma level but not in serum concentrations in suicide behavior: A systematic review and meta‐analysis

et al. 2017

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IntroductionSuicide is known as a major health concern worldwide. There is evidence for the role of brain‐derived neurotrophic factor (BDNF) in suicide behavior. Therefore, this factor has been proposed as a biomarker for suicide behavior. Clinical studies have measured BDNF concentrations at central and peripheral levels. As a consequence, the aim of this study was to assess BDNF levels in blood plasma and serum to see whether there is a difference in concentrations in patients with suicide behavior when compared to those in controls, using a meta‐analysis approach.MethodsWe conducted a systematic review and meta‐analysis. The search strategy was performed using three databases: PubMed, EBSCO and ScienceDirect. The meta‐analysis included a total of nine case–control studies, six measured the BDNF level in serum and three in plasma in suicide behavior.ResultsA decrease in BDNF levels in plasma was observed (d = −0.73, 95% CI −1.42 to −0.03 pg/ml). In the case of serum concentrations, no BDNF differences were encountered between cases and controls (d = 0.09, 95% CI −0.31 to 0.13 ng/ml, p(Q) = .92).ConclusionsAccording to the results found in the present meta‐analysis, the plasma BDNF level could be suggest as a potential biomarker in suicide behavior. However, since the number of studies included in the analysis is limited, a larger number is necessary to determine conclusively the role of BDNF as a biomarker in suicide behavior.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Decrease in brain‐derived neurotrophic factor at plasma level but not in serum concentrations in suicide behavior: A systematic review and meta‐analysis

et al. 2017

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“…Also, interleukins 1a, 1b, and 6, TNF-alfa, or C-reactive protein have been widely described elevated in MS patients [27] as in patients with psychiatric manifestations mainly expressing psychosomatic symptoms [28], [29]. At this time, we were unable to measure inflammation biomarkers, but we believe that the difference found between RR and SP could be related to the inflammation process of MS, where RR-MS patients have been found to have a more acute inflammation response than SP-MS patients.…”

Section: Discussionmentioning

confidence: 99%

BDNF and Tau as biomarkers of severity in Multiple Sclerosis

Islas-Hernandez

Aguilar-Talamantes

Bertado-Cortés

et al. 2017

Preprint

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Aims: Determine if serum levels of tau and brain-derived neurotrophic factor (BDNF) can be used as severity biomarkers in multiple sclerosis (MS).Patients and methods: Subjects with MS, older than 18 and younger than 55 years were included; 74 patients with a diagnosis of relapsing-remitting MS (RRMS), 11 with secondary-progressive MS (SPMS), and 88 controls were included. Total tau and BDNF were measured by western blot.Results: Increased tau and decreased BDNF in MS patients compared to controls was found.Total-tau has a peak in RRMS, the second decile of the Multiple Sclerosis Severity Score, and in the lowest Expanded Disability Status Scale and is no different than controls for SPMS patients and the most severe cases of MS.Conclusion: BDNF is a good biomarker for diagnosis of MS but not for severity or progression. Tau appears to have a more active role in the progression of MS.

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“…This is especially the case when the immunological response is out of proportion to the injury sustained or when immune activation occurs chronically. Indeed, elevated levels of inflammatory markers have been found among depressed individuals (Haapakoski et al, 2015), and among suicide attempters, that reported greater levels of perceived stress, and these individuals also displayed lower levels of neurotrophins (Priya et al, 2016). In addition, the induction of inflammatory states through the administration of an endotoxin may alter the recognition of mood related stimuli, which may contribute to the risk of depression (Benson et al, 2017).…”

Section: Inflammation and Depressionmentioning

confidence: 99%

From Risk to Resilience: How Lifestyle Factors Interact with Early-Life Trauma, Genetic Polymorphisms, and Stress, in Predicting Risk for Depression

Howell¹

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Despite the link that risk factors, such as early-life stressors and genetic polymorphisms, have with the development of depressive symptoms, not every individual who is 'at risk' develops this disorder. It has been suggested that lifestyle factors, such as diet and exercise, may play a critical role in this regard. To date, there have been few reports examining the interactions between these lifestyle factors and other risk factors in promoting depressive features. The purpose of the present investigation was to assess the moderating effects of dietary pattern and exercise frequency, in the relations between stressors experienced early in life and psychological outcomes (depressive symptoms and creative problem solving), as well as current stressors and a biological outcome (cortisol response). In addition, the present investigation sought to examine whether these lifestyle variables might interact with immune related gene mutations, in predicting depressive symptoms and other related measures (executive functioning, coping flexibility, and coping endorsement), as both depression and these lifestyle factors are related to immune functioning.In Study 1 (N=278), physical trauma was negatively related to performance on the Remote Associates Test, a measure of creative problem solving, but this relation only existed for individuals who consumed smaller amounts of healthy foods. It was also found that sexual trauma was positively related to depressive symptoms, but this relation was stronger among participants who consumed greater amounts of unhealthy foods. Study 2 (N=163) demonstrated that dietary patterns interact with immune related genetic polymorphisms and sex, in predicting depressive symptoms, coping flexibility, and coping strategy endorsement. Building upon the findings of the previous study, Study 3 (N=144) indicated that diet and exercise interacted with immune related polymorphisms and sex, in predicting performance on the Iowa Gambling Task iii (a measure of executive functioning). Finally, Study 4 (N=81) showed that adherence to an unhealthy dietary pattern was associated with elevated levels of cortisol in response to the Trier Social Stress Test. Together, these studies suggest that dietary pattern and exercise habits, can interact with stressors (both current and past) and immune related polymorphisms, in predicting risk for depression.iv

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Association of neurotrophins, inflammation and stress with suicide risk in young adults

Cited by 55 publications

References 25 publications

Decrease in brain‐derived neurotrophic factor at plasma level but not in serum concentrations in suicide behavior: A systematic review and meta‐analysis

Decrease in brain‐derived neurotrophic factor at plasma level but not in serum concentrations in suicide behavior: A systematic review and meta‐analysis

BDNF and Tau as biomarkers of severity in Multiple Sclerosis

From Risk to Resilience: How Lifestyle Factors Interact with Early-Life Trauma, Genetic Polymorphisms, and Stress, in Predicting Risk for Depression

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