Association of Neighborhood Disadvantage in Childhood With DNA Methylation in Young Adulthood

Reuben, Aaron; Sugden, Karen; Arseneault, Louise; Corcoran, David L.; Danese, Andrea; Fisher, Helen L.; Moffitt, Terrie E.; Newbury, Joanne B.; Odgers, Candice L.; Prinz, Joey A.; Rasmussen, Line Jee Hartmann; Williams, Ben; Mill, Jonathan; Caspi, Avshalom

doi:10.1001/jamanetworkopen.2020.6095

Cited by 60 publications

(56 citation statements)

References 40 publications

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“…Environmental conditions, both indoor and outdoor, have been linked to objective measures of the stress and relaxation response, such as heart rate variability and cortisol levels. In striking recent studies, environmental conditions have been associated with epigenetic changes in children living in disadvantaged neighborhoods ( 155 , 156 ). As most Americans currently spend over 90% of their time indoors, the critical role of building design and environmental conditions on cognitive function, sleep, stress and productivity is increasingly being realized ( 157 , 158 ).…”

Section: Socioecological Influences Environment and Exposuresmentioning

confidence: 99%

Prioritized Research for the Prevention, Treatment, and Reversal of Chronic Disease: Recommendations From the Lifestyle Medicine Research Summit

Vodovotz

Barnard

et al. 2020

Front. Med.

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Declining life expectancy and increasing all-cause mortality in the United States have been associated with unhealthy behaviors, socioecological factors, and preventable disease. A growing body of basic science, clinical research, and population health evidence points to the benefits of healthy behaviors, environments and policies to maintain health and prevent, treat, and reverse the root causes of common chronic diseases. Similarly, innovations in research methodologies, standards of evidence, emergence of unique study cohorts, and breakthroughs in data analytics and modeling create new possibilities for producing biomedical knowledge and clinical translation. To understand these advances and inform future directions research, The Lifestyle Medicine Research Summit was convened at the University of Pittsburgh on December 4–5, 2019. The Summit's goal was to review current status and define research priorities in the six core areas of lifestyle medicine: plant-predominant nutrition, physical activity, sleep, stress, addictive behaviors, and positive psychology/social connection. Forty invited subject matter experts (1) reviewed existing knowledge and gaps relating lifestyle behaviors to common chronic diseases, such as cardiovascular disease, diabetes, many cancers, inflammatory- and immune-related disorders and other conditions; and (2) discussed the potential for applying cutting-edge molecular, cellular, epigenetic and emerging science knowledge and computational methodologies, research designs, and study cohorts to accelerate clinical applications across all six domains of lifestyle medicine. Notably, federal health agencies, such as the Department of Defense and Veterans Administration have begun to adopt “whole-person health and performance” models that address these lifestyle and environmental root causes of chronic disease and associated morbidity, mortality, and cost. Recommendations strongly support leveraging emerging research methodologies, systems biology, and computational modeling in order to accelerate effective clinical and population solutions to improve health and reduce societal costs. New and alternative hierarchies of evidence are also be needed in order to assess the quality of evidence and develop evidence-based guidelines on lifestyle medicine. Children and underserved populations were identified as prioritized groups to study. The COVID-19 pandemic, which disproportionately impacts people with chronic diseases that are amenable to effective lifestyle medicine interventions, makes the Summit's findings and recommendations for future research particularly timely and relevant.

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Section: Socioecological Influences Environment and Exposuresmentioning

confidence: 99%

Prioritized Research for the Prevention, Treatment, and Reversal of Chronic Disease: Recommendations From the Lifestyle Medicine Research Summit

Vodovotz

Barnard

et al. 2020

Front. Med.

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“…Epigenetic mechanisms, specifically DNA methylation (DNAm), offer insights into possible molecular pathways. DNAm regulates gene expression without altering the underlying DNA sequence, is associated with health outcomes and mortality, and responsive to exogenous factors, including area-level environmental exposures [ 20 , 21 , 25 – 27 ]. Several measures of DNAm aging, also known as “epigenetic clocks,” have been developed using DNA microarray technology and statistical algorithms to identify alterations in DNAm that are highly correlated with chronological age [ 28 – 30 ].…”

Section: Introductionmentioning

confidence: 99%

Neighborhood environment, social cohesion, and epigenetic aging

Martin

Ward‐Caviness

Dhingra

et al. 2021

Aging

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Living in adverse neighborhood environments has been linked to risk of aging-related diseases and mortality; however, the biological mechanisms explaining this observation remain poorly understood. DNA methylation (DNAm), a proposed mechanism and biomarker of biological aging responsive to environmental stressors, offers promising insight into potential molecular pathways. We examined associations between three neighborhood social environment measures (poverty, quality, and social cohesion) and three epigenetic clocks (Horvath, Hannum, and PhenoAge) using data from the Detroit Neighborhood Health Study (n=158). Using linear regression models, we evaluated associations in the total sample and stratified by sex and social cohesion. Neighborhood quality was associated with accelerated DNAm aging for Horvath age acceleration (β = 1.8; 95% CI: 0.4, 3.1), Hannum age acceleration (β = 1.7; 95% CI: 0.4, 3.0), and PhenoAge acceleration (β = 2.1; 95% CI: 0.4, 3.8). In models stratified on social cohesion, associations of neighborhood poverty and quality with accelerated DNAm aging remained elevated for residents living in neighborhoods with lower social cohesion, but were null for those living in neighborhoods with higher social cohesion. Our study suggests that living in adverse neighborhood environments can speed up epigenetic aging, while positive neighborhood attributes may buffer effects.

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“…In a study of 1,226 adults in the Multi-Ethnic Study of Atherosclerosis (MESA), the neighborhood social environment, measured as a summary score that included social cohesion, was associated with DNAm in stress-and inflammation-related genes (16). In our study, men living in neighborhoods with higher neighborhood social cohesion (15,16). Additional pathways, such as smoking status and dietary behaviors, may affect these associations.…”

Section: Discussionmentioning

confidence: 62%

“…Growing evidence suggests that accelerated biological aging at the cellular-and molecular-levels may help to explain the mechanisms linking adverse neighborhood environments to mortality (12)(13)(14)(15)(16)(17)(18)(19). Epigenetic mechanisms, particularly DNA methylation (DNAm), has offered promising insights into possible molecular pathways.…”

Section: Introductionmentioning

confidence: 99%

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Neighborhood environment, social cohesion, and epigenetic aging

Martin

Ward‐Caviness

Dhingra

et al. 2020

Preprint

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Living in adverse neighborhood environments have been linked to increased risk of aging-related diseases and mortality; however, the biological mechanisms explaining this observation remain poorly understood. DNA methylation (DNAm), a proposed biomarker of biological aging responsive to environmental stressors, offers promising insight into molecular pathways. We examined associations of three measures of neighborhood conditions (poverty, quality, and social cohesion) with three different epigenetic clocks (Horvath, Hannum, and Levine) using data from the Detroit Neighborhood Health Study (n=158). Using linear regression models, we evaluated associations in the total sample and stratified by gender and social cohesion. Differential effects by gender were found between men and women. Neighborhood poverty was associated with PhenoAge acceleration among women, but not among men (women: β = 1.4; 95% CI: -0.4, 3.3 vs. men: β = -0.3; 95% CI: -2.2, 1.5) in fully adjusted models. In models stratified on social cohesion, association of neighborhood poverty and quality with accelerated DNAm aging remained elevated for residents living in neighborhoods with lower social cohesion, but were null for those living in neighborhoods with higher social cohesion. Our study suggests that living in adverse neighborhood conditions can speed up epigenetic aging, while positive neighborhood characteristics may buffer effects.

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Association of Neighborhood Disadvantage in Childhood With DNA Methylation in Young Adulthood

Cited by 60 publications

References 40 publications

Prioritized Research for the Prevention, Treatment, and Reversal of Chronic Disease: Recommendations From the Lifestyle Medicine Research Summit

Prioritized Research for the Prevention, Treatment, and Reversal of Chronic Disease: Recommendations From the Lifestyle Medicine Research Summit

Neighborhood environment, social cohesion, and epigenetic aging

Neighborhood environment, social cohesion, and epigenetic aging

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