Association of nasal microbiome and asthma control in patients with chronic rhinosinusitis

Yang, Hyo Joon; LoSavio, Phillip; Engen, Phillip A.; Naqib, Ankur; Mehta, Arpita; Kota, Raj; Khan, Rafsa; Tobin, Mary C.; Green, Stefan J.; Schleimer, Robert P.; Keshavarzian, Ali; Batra, Pete S.; Mahdavinia, Mahboobeh

doi:10.1111/cea.13255

Cited by 14 publications

(18 citation statements)

References 15 publications

(23 reference statements)

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“…Recently, it was demonstrated that the gut microbiome plays a critical role in the pathogenesis of various allergic diseases such as asthma and eczema . Despite the low biomass issue, studies also attempted to study the microbial composition of other body sites for more direct linkage to the extraintestinal diseases . As for ARC, the relationship between nasopharyngeal and ocular microbiome and the disease remained unexplored.…”

Section: Introductionmentioning

confidence: 99%

“…6 Despite the low biomass issue, studies also attempted to study the microbial composition of other body sites for more direct linkage to the extraintestinal diseases. 7,8 As for ARC, the relationship between nasopharyngeal and ocular microbiome and the disease remained unexplored. In the present study, the nasopharyngeal and ocular microbiome from both healthy subjects and ARC patients were studied using 16S amplicon sequencing.…”

Section: Introductionmentioning

confidence: 99%

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Characterization of ocular and nasopharyngeal microbiome in allergic rhinoconjunctivitis

Yau

Hou

Tsui

et al. 2019

Pediatric Allergy Immunology

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Background Allergic rhinoconjunctivitis (ARC) is a prevalent allergic condition in the pediatric population. Microbial dysbiosis has increasingly been recognized to influence on host immunity and allergic diseases. However, the microbial profile of ARC has not been characterized. This cross‐sectional study aims to evaluate the changes in nasal and ocular surface microbiome of children with ARC. Methods Ocular and nasopharyngeal swabs were collected from controls and pediatric ARC cases for 16S rRNA amplicon sequencing. The bacterial community profile was analyzed. The correlation of the microbial diversity with the ARC‐related clinical scores was studied. Results A total of 23 patients with ARC and 17 healthy controls were recruited;30 were ocular samples (15 controls vs 15 ARC), while 40 were nasal samples (17controls vs 23 ARC) The alpha diversity of nasopharyngeal microbiome was significantly higher in ARC patients than healthy controls (P < 0.01), but not for ocular microbiome. The clinical scores in all subjects were negatively correlated with the Shannon diversity for ocular (P = 0.014) and positively correlated with nasopharyngeal (P = 0.010) microbiome. While the ocular microbiome remained significantly distinct from nasopharyngeal microbiome in terms of both alpha and beta diversity in both healthy subjects and ARC patients, significant differences of relative abundance of certain phyla (Bacteroidetes, Cyanobacteria, and Deinococcus‐Thermus) and genera (Dolosigranulum and Moraxella) between nasal and ocular surfaces were only detected in healthy controls, but not in the ARC subjects, suggesting the microbial composition at both body sites becoming more similar at disease state. Conclusion This study reported (a) a higher alpha diversity in ocular than nasopharyngeal microbiome in both ARC patients and controls, and (b) nasopharyngeal microbiome became more diverse in ARC patients than in controls. Our results suggested an interaction of the microbiome between ocular and nasal compartments in patients with ARC.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characterization of ocular and nasopharyngeal microbiome in allergic rhinoconjunctivitis

Yau

Hou

Tsui

et al. 2019

Pediatric Allergy Immunology

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“…than patients who did not visit the ER for symptoms. 101 These findings are interesting given that Streptococcus has been linked to asthma development in children 102 and Burkholderia is associated with decreased lung function in patients with cystic fibrosis. 103 However, how these bacteria are specifically involved in CRS pathogenesis is not known.…”

Section: Pathogens and Chronic Rhinosinusitismentioning

confidence: 98%

“…100 In a separate study of 111 CRS cases, no significant difference in the diversity of bacterial species was noted between patients with CRS with and without asthma. 101 Although, the relative abundance of Streptococcus spp. was significantly higher in patients with CRS with asthma as compared with without.…”

Section: Pathogens and Chronic Rhinosinusitismentioning

confidence: 99%

“…was significantly higher in patients with CRS with asthma as compared with without. 101 Furthermore, asthmatic patients with CRS with emergency room (ER) visits for asthma had significantly higher relative abundance of Proteobacteria phylum (likely due to increased Burkholderia spp.) than patients who did not visit the ER for symptoms.…”

Section: Pathogens and Chronic Rhinosinusitismentioning

confidence: 99%

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Sinus Infections, Inflammation, and Asthma

Staudacher

Stevens

2019

Immunology and Allergy Clinics of North America

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KEYWORDSAcute rhinosinusitis Chronic rhinosinusitis Nasal polyp Infection Inflammation Asthma Microbiome KEY POINTSRhinosinusitis is clinically defined as the presence of nasal drainage (anterior or posterior), nasal congestion, facial pain/pressure, and/or reduced sense of smell. In acute rhinosinusitis, nasal symptoms last for less than 12 weeks and inflammation is often secondary to a viral or bacterial infection. In chronic rhinosinusitis (CRS), nasal symptoms persist for longer than 12 weeks and the inflammation observed is secondary to impairments in the epithelial barrier, dysregulation of the host immune response, and potentially infections (or colonization) by pathogens. CRS and asthma have a strong clinical association and share similar pathophysiologic mechanisms in support of the unified airway hypothesis.Acute rhinosinusitis (ARS) is defined as the presence of nasal drainage (anterior or posterior), nasal congestion, facial pain/pressure, and/or reduced sense of smell. Depending on which guidelines are followed, ARS symptoms last either for less than 4 weeks 1 or 12 weeks. 2,3 ARS is a clinical diagnosis, and objective confirmation by sinus computed tomography (CT) scan or nasal endoscopy is generally not indicated. Patients can have more than one episode of ARS each year but importantly, they are asymptomatic in the intervening periods.Acute rhinosinusitis is extremely common. Studies specifying ARS found a disease prevalence of 6% to 15%, 2,4 with an estimated 0.035% of the population suffering from recurrent episodes. 5 Between 2006 and 2010, there were an estimated 21.4 million ambulatory care visits with a primary diagnosis of ARS. 6 Furthermore, in 2015 alone, acute upper respiratory infection (or presumed ARS) was one of the top 20 leading diagnoses for outpatient office visits. 7

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Comparison between upper and lower airway microbiome profiles in chronic rhinosinusitis patients

Hernaiz‐Leonardo,

Ryu,

Pascual

et al. 2024

Int Forum Allergy Rhinol

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BackgroundDysregulation of the airway microbiota is thought to contribute to airway inflammation in both chronic rhinosinusitis (CRS) and asthma. However, the relationship between the upper and lower airway microbiome remains unclear.MethodsSinus and lung brushes were collected from 29 CRS participants undergoing sinus surgery. DNA was extracted and submitted for 16s rRNA microbiome sequencing. Alpha and beta diversity metrics, taxonomic composition, and differences between individual taxa were compared for paired sinus and bronchial samples.ResultsTwenty‐three out of 29 participants had sufficient samples for analysis. The mean (standard deviation) age was 51.59 (14.57) years, and 10 (44%) patients were female. Twelve (52%) patients had comorbid asthma. Sinus brushes had significantly higher alpha diversity indexes (Shannon and Faith) compared to bronchial brushes (p < 0.001). Beta diversity metrics were significantly different between the sinus and bronchial samples. Principal coordinate analysis showed no clustering of paired nasal and bronchial samples. Sinus brushes had significantly more Lawsonella, Corynebacterium, and Staphylococcus compared to bronchia brushes, while the latter were enriched in Tropheryma and Sphingomonas, among others (false discovery rate [FDR]‐adjusted p < 0.01). Finally, CRS patients with comorbid asthma had significantly higher Pseudomonas and Peptoniphilus in sinus brushes and lower Prevotella in bronchial brushes when compared to non‐asthmatics (FDR‐adjusted p < 0.01).ConclusionThe sinus and bronchial bacterial microbiomes differ in important ways. Our study suggests that migration of bacteria from the sinus into the lower airways is unlikely in patients with CRS.

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Association of nasal microbiome and asthma control in patients with chronic rhinosinusitis

Cited by 14 publications

References 15 publications

Characterization of ocular and nasopharyngeal microbiome in allergic rhinoconjunctivitis

Characterization of ocular and nasopharyngeal microbiome in allergic rhinoconjunctivitis

Sinus Infections, Inflammation, and Asthma

Comparison between upper and lower airway microbiome profiles in chronic rhinosinusitis patients

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