Association of n-3 polyunsaturated fatty acids with soluble thrombomodulin as a marker of endothelial damage: A cross-sectional pilot study

Kawauchi, Kenji; Tani, Shigemasa; Nagao, Ken; Hirayama, Atsushi

doi:10.1016/j.jjcc.2014.02.004

Cited by 7 publications

(6 citation statements)

References 25 publications

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“…7) It seems therefore likely that in vivo, EPA and DHA exhibit different physiological activities. [8][9][10][11] A strong positive correlation is known to exist between serum EPA and DHA levels, and this was also shown in our study cited above. [4][5][6] Because serum EPA and serum DHA levels serve as confounding factors for each other, there are limits to discussing their effects on the incidence of coronary artery disease.…”

supporting

confidence: 88%

Association of Fish Consumption-Derived Ratio of Serum n-3 to n-6 Polyunsaturated Fatty Acids and Cardiovascular Risk With the Prevalence of Coronary Artery Disease

et al. 2015

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SummaryWe investigated the relationships between the ratio of serum n-3 polyunsaturated fatty acids (n-3PUFAs: eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]) to n-6PUFA (arachidonic acid [AA]) and the prevalence of coronary artery disease (CAD), and assessed the association of the ratio of serum n-3 to n-6 PUFAs with atherosclerosis-related markers.This study was designed as a hospital-based cross-sectional study of 649 consecutive outpatients who had undergone regular examinations between April 2009 and October 2009. We divided the patients into 5 groups based on the quintiles of the EPA/AA ratio or quintiles of the DHA/AA ratio to determine independent factors for the prevalence of CAD.In multivariate logistic regression analyses after adjustment for coronary risk factors and serum n-3PUFAs levels to minimize confounding factors to the extent possible because the serum levels of EPA and DHA showed a strong correlation (r = 0.812, P < 0.0001), the group with the highest EPA/AA ratio had a lower probability of CAD prevalence (odds ratio: 0.328, 95% confidence interval: 0.113 to 0.956, P = 0.041), but this was not true for the DHA/AA ratio. Multivariate analysis showed an increase in the EPA/AA ratio, but not in the DHA/AA ratio, was associated with effects on atherosclerosis-related markers, especially triglyceride-rich lipoproteins, high-density lipoprotein cholesterol (HDL-C) containing apolipoprotein A-1, and leukocyte count in an anti-atherogenic direction.The results suggest a higher EPA/AA ratio, but not a higher DHA/AA ratio, might be associated with a lower prevalence of CAD and improvements of triglyceride metabolism and HDL metabolism, and systemic inflammation. (Int Heart J 2015; 56: 260-268)

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confidence: 88%

Association of Fish Consumption-Derived Ratio of Serum n-3 to n-6 Polyunsaturated Fatty Acids and Cardiovascular Risk With the Prevalence of Coronary Artery Disease

et al. 2015

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“…Having said this, clinical trials on the effects of n-3 PUFA on endothelial function are significantly heterogeneous in number of included participants; inclusion criteria: age of participants, healthy or disease state, have been studied; markers of endothelial function: in addition to flow-mediated dilation, at least 7 different classes of surrogate markers have been tested in the last 5 years. The most frequent categories tested, according to their different pathophysiological roles, are proinflammatory and anti-inflammatory cytokines, endothelial progenitor cells, markers of platelet activation, of fibrinolysis, of thrombosis, and of coagulation, and markers of oxidative stress [ 98 – 102 ]; dose and duration of treatment: doses ranging from 0.45 up to 4 grams have been tested as well as treatments ranging from 4 to 52 weeks [ 58 , 103 , 104 ]; forms of n-3 PUFA: EPA, DHA, or ALA has been administered alone or in combination; concomitant therapy: most of the studies on disease states do not provide accurate information on concomitant therapy, particularly on drugs known to improve endothelial function such as statins and ACE inhibitors/angiotensin receptor blockers. The presence of a robust concomitant therapy might improve endothelial function independently of n-3 PUFA (especially at low doses) in high risk patients.…”

Section: N-3 Pufa and Endothelial Dysfunction: In Vivo Human Studimentioning

confidence: 99%

“…markers of endothelial function: in addition to flow-mediated dilation, at least 7 different classes of surrogate markers have been tested in the last 5 years. The most frequent categories tested, according to their different pathophysiological roles, are proinflammatory and anti-inflammatory cytokines, endothelial progenitor cells, markers of platelet activation, of fibrinolysis, of thrombosis, and of coagulation, and markers of oxidative stress [ 98 – 102 ];…”

Section: N-3 Pufa and Endothelial Dysfunction: In Vivo Human Studimentioning

confidence: 99%

Omega-3 Polyunsaturated Fatty Acids: Structural and Functional Effects on the Vascular Wall

Zanetti

Grillo

Losurdo

et al. 2015

BioMed Research International

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Omega-3 polyunsaturated fatty acids (n-3 PUFA) consumption is associated with reduced cardiovascular disease risk. Increasing evidence demonstrating a beneficial effect of n-3 PUFA on arterial wall properties is progressively emerging. We reviewed the recent available evidence for the cardiovascular effects of n-3 PUFA focusing on structural and functional properties of the vascular wall. In experimental studies and clinical trials n-3 PUFA have shown the ability to improve arterial hemodynamics by reducing arterial stiffness, thus explaining some of its cardioprotective properties. Recent studies suggest beneficial effects of n-3 PUFA on endothelial activation, which are likely to improve vascular function. Several molecular, cellular, and physiological pathways influenced by n-3 PUFA can affect arterial wall properties and therefore interfere with the atherosclerotic process. Although the relative weight of different physiological and molecular mechanisms and the dose-response on arterial wall properties have yet to be determined, n-3 PUFA have the potential to beneficially impact arterial wall remodeling and cardiovascular outcomes by targeting arterial wall stiffening and endothelial dysfunction.

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“…In regression analysis, no significant associations between sTM levels and age, BMI or smoking habits were observed (Table 2). Previous studies showed inconsistent associations between these variables and sTM levels [47, 48, 51]. In our study, we did not include any older aged (>60 years) subject.…”

Section: Discussionmentioning

confidence: 98%

“…Several studies have considered age, sex, BMI, smoking and other characteristics as possible confounders for sTM [46–51]. Dohi et al (2003) reported that sTM levels were higher in hypertensive patients than those of normotensive control group [52].…”

Section: Discussionmentioning

confidence: 99%

Association between arsenic exposure and soluble thrombomodulin: A cross sectional study in Bangladesh

et al. 2017

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Chronic exposure to arsenic is associated with increased morbidity and mortality from cardiovascular disease (CVD); however, plausible biomarker for early prediction and the underlying mechanism of arsenic-related CVD have not yet been clearly understood. Endothelial dysfunction plays a central role in the development of CVD. We hypothesized that endothelial damage or dysfunction is an important aspect and may be an early event of arsenic-related CVD. Soluble thrombomodulin (sTM) in serum is thought to be a specific and stable marker for endothelial damage or dysfunction. This study was designed to evaluate the association between chronic exposure to arsenic and sTM among human subjects in arsenic-endemic and non-endemic rural areas in Bangladesh. A total of 321 study subjects (217 from arsenic-endemic areas and 104 from a non-endemic area) were recruited. Subjects’ arsenic exposure levels (i.e., drinking water, hair and nail arsenic concentrations) were measured by Inductively Coupled Plasma Mass Spectroscopy. The subjects’ serum sTM levels were quantified by immunoassay kit. The average sTM levels of the subjects in arsenic-endemic and non-endemic areas were 4.58 ± 2.20 and 2.84 ± 1.29 (ng mL-1) respectively, and the difference was significant (p<0.001). Arsenic exposure levels showed a significant (water arsenic: rs = 0.339, p<0.001, hair arsenic: rs = 0.352, p<0.001 and nail arsenic: rs = 0.308, p<0.001) positive associations with sTM levels. Soluble TM levels were higher in the higher exposure gradients if we stratified the subjects into tertile groups (low, medium and high) based on the arsenic concentrations of the subjects’ drinking water, hair and nails. Finally, increased levels of sTM were negatively correlated with high density lipoprotein cholesterol (HDL-C), and positively correlated with intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). Results of this study show that chronic exposure to arsenic has mild to moderate association with sTM levels.

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Association of n-3 polyunsaturated fatty acids with soluble thrombomodulin as a marker of endothelial damage: A cross-sectional pilot study

Cited by 7 publications

References 25 publications

Association of Fish Consumption-Derived Ratio of Serum n-3 to n-6 Polyunsaturated Fatty Acids and Cardiovascular Risk With the Prevalence of Coronary Artery Disease

Association of Fish Consumption-Derived Ratio of Serum n-3 to n-6 Polyunsaturated Fatty Acids and Cardiovascular Risk With the Prevalence of Coronary Artery Disease

Omega-3 Polyunsaturated Fatty Acids: Structural and Functional Effects on the Vascular Wall

Association between arsenic exposure and soluble thrombomodulin: A cross sectional study in Bangladesh

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