Association of Myocardial Strain With Left Ventricular Geometry and Progression of Hypertensive Heart Disease

Hare, James L.; Brown, Joseph; Marwick, Thomas H.

doi:10.1016/j.amjcard.2008.02.101

Cited by 53 publications

(30 citation statements)

References 27 publications

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“…Although the associations between GLS and MACE were not significant in subgroups without HTN The role of changes in LV circumferential function has been controversial, relative to the LV longitudinal function in HHD (13,(25)(26)(27)(28)(29). In the present study, GCS was not associated with MACE, and its temporal change was minor.…”

Section: Discussioncontrasting

confidence: 77%

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Prognostic Implications of LV Strain Risk Score in Asymptomatic Patients With Hypertensive Heart Disease

Saito¹,

Khan

Stoklosa

et al. 2016

JACC: Cardiovascular Imaging

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Section: Discussioncontrasting

confidence: 77%

“…Although LVH is associated with impaired myocardial strain (13), the independent prognostic implications of strain in patients with HHD have remained undefined. In addition, there are scant data about the natural history of LVH, LV morphology, and function, which could clarify the pathogenic mechanism of development of cardiac events in HHD (14).…”

mentioning

confidence: 99%

Prognostic Implications of LV Strain Risk Score in Asymptomatic Patients With Hypertensive Heart Disease

Saito¹,

Khan

Stoklosa

et al. 2016

JACC: Cardiovascular Imaging

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“…These reports evaluated cardiac function only in the active phase of the disease and demonstrated that patients with CS commonly have abnormal LV geometry (with increased LV mass index and relative wall thickness) and LV diastolic dysfunction (impaired relaxation LV filling pattern), but preserved LVejection fraction (4,18). The use of more sensitive echocardiographic parameters (such as mid-wall fractional shortening or strain imaging) may enable the detection of subtle LV systolic dysfunction, yielding important clinical implications for the risk stratification and clinical management of these patients (4,19). In this regard, Muiesan et al demonstrated the presence of subclinical LV systolic dysfunction in patients with active CS by evaluating the LV mid-wall fractional shortening (4).…”

Section: Discussionmentioning

confidence: 99%

Cardiac dysfunction is reversed upon successful treatment of Cushing's syndrome

Pereira

Delgado²,

Romijn³

et al. 2010

European Journal of Endocrinology

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Objective: In patients with active Cushing's syndrome (CS), cardiac structural and functional changes have been described in a limited number of patients. It is unknown whether these changes reverse after successful treatment. We therefore evaluated the changes in cardiac structure and dysfunction after successful treatment of CS, using more sensitive echocardiographic parameters (based on two-dimensional strain imaging) to detect subtle changes in cardiac structure and function. Methods: In a prospective study design, we studied 15 consecutive CS patients and 30 controls (matched for age, sex, body surface area, hypertension, and left ventricular (LV) systolic function). Multidirectional LV strain was evaluated by two-dimensional speckle tracking strain imaging. Systolic (radial thickening, and circumferential and longitudinal shortening) and diastolic (longitudinal strain rate at the isovolumetric relaxation time (SR IVRT )) parameters were measured. Results: At baseline, CS patients had similar LV diameters but had significantly more LV hypertrophy and impaired LV diastolic function, compared to controls. In addition, CS patients showed impaired LV shortening in the circumferential (K16.5G3.5 vs K19.7G3.4%, PZ0.013) and longitudinal (K15.9G1.9 vs K20.1G2.3%, P!0.001) directions and decreased SR IVRT (0.3G0.15 vs 0.4 G0.2/ s, PZ0.012) compared to controls. After normalization of corticosteroid excess, LV structural abnormalities reversed, LV circumferential and longitudinal shortening occurred, and SR IVRT normalized. Conclusion: CS induces not only LV hypertrophy and diastolic dysfunction but also subclinical LV systolic dysfunction, which reverses upon normalization of corticosteroid excess.

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“…Strain rate was also found significantly reduced in patients with concentric hypertrophy. Baseline myocardial tissue deformation, but not evolution, was found in association with left ventricular geometry in treated hypertensive patients [25].…”

Section: Discussionmentioning

confidence: 98%

Relationship between left ventricular hypertrophy, hypertensive retinopathy, microalbuminuria and echocardiographic modalities in newly diagnosed hypertensive patients

Bilge

Atılgan

Onur

et al. 2010

Int J Cardiovasc Imaging

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Longitudinal myocardial function (LMF) may be impaired while systolic function is still normal. We investigated relationship between LMF and hypertensive organ damage in newly diagnosed stage I hypertensive patients. A total of 57 patient with never treated stage I hypertension and 48 matched healthy control subject were enrolled in the study. Conventional 2-D, Doppler and tissue wave Doppler imaging (TDI) echocardiography were used. LMF was evaluated by the septal and lateral strain (S) and strain rate (SR) measurements. Hypertensive complications were evaluated by the urine microalbumin levels and retinal examination. A multivariate regression analysis was perfomed to assess the relation between the variables. Ejection fraction, mid-wall fractional shortenning, systolic movement rates (TDs) in TDI were similar both in hypertensive and control groups. In patients with left ventricular hypertrophy, septal TDs (7.29 +/- 1.28 vs. 8.06 +/- 1.19 cm, P = 0.03), lateral TDs (8.46 +/- 1.83 vs. 9.87 +/- 2.42 cm, P = 0.01) and lateral S (-13.02 +/- 7.83 vs. -18.86 +/- 8.60%, P = 0.01) values were significantly lower. Septal S (-13.67 +/- 3.52 vs. -19.09 +/- 5.96%, P < 0.01) and SR (-0.83 +/- 0.29 vs. -1.22 +/- 0.28 1/S, P < 0.01) were significantly decreased in hypertensive patients with microalbuminuria. Septal S value was also significantly decreased in patients with retinopathy (-14.76 +/- 5.55 vs. -20.20 +/- 5.44%, P = 0.01). Multivariate analysis showed that only septal and lateral S values were independent factors for the retinopathy and left ventricular hypertrophy, respectively. In hypertensive patients, LMF established by the measurement of S and SR, might be impaired and also related with end organ damage while global circumferential function is preserved.

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Association of Myocardial Strain With Left Ventricular Geometry and Progression of Hypertensive Heart Disease

Cited by 53 publications

References 27 publications

Prognostic Implications of LV Strain Risk Score in Asymptomatic Patients With Hypertensive Heart Disease

Prognostic Implications of LV Strain Risk Score in Asymptomatic Patients With Hypertensive Heart Disease

Cardiac dysfunction is reversed upon successful treatment of Cushing's syndrome

Relationship between left ventricular hypertrophy, hypertensive retinopathy, microalbuminuria and echocardiographic modalities in newly diagnosed hypertensive patients

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