Association of Mycoplasma Pneumoniae Infection with Henoch-Schonlein Purpura

Abstract

We present a child with Henoch-Schonlein purpura and Mycoplasma pneumoniae infection, an association that was rarely described in the literature. The infection was confirmed serologically and by using PCR.

Unusual Eruptions Associated with <b><i>Mycoplasma pneumoniae</i></b> Respiratory Infections: Review of the Literature

“…Less commonly, they present with targetoid lesions and nonpitting edema in the context of acute hemorrhagic edema of young children, which is considered the infantile variant of Henoch-Schönlein syndrome, or with urticarial plaques in the context of urticarial vasculitis. Our review disclosed 21 cases of leukocytoclastic vasculitides associated with M. pneumoniae infection: 18 cases of Henoch-Schönlein syndrome, 1 case of acute hemorrhagic edema and 2 cases of urticarial vasculitis [42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62]. …”

“…Using the described strategy, 94 reports were retained for the final analysis [4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97]: 1 in German [23], 1 in Italian […”

Epidemiology and clinical characteristics of Henoch-Schönlein purpura associated with Mycoplasma pneumoniae infection in 131 children in Hubei province, China

“…Several previous studies have reported direct evidence of HSP caused by MP. [11][12][13] It is known that the seasonality of HSP is determined by the factors of these triggers and that age distribution and manifestations vary. 1 The epidemiological characteristics of a disease can help determine the aetiologic agents of the disease.…”

Pathophysiological Relationship between Infections and Systemic Vasculitis

“…One study reported that 29 of 55 children [ 17 , 18 ] were isolated with Helicobacter pylori (49.3% of Chinese infants with IgA vasculitis compared to 23.4% of controls) [ 19 , 20 ]. Staphylococcus aureus [ 21 ] and Mycoplasma pneumoniae [ 22 ] are additional examples of these associations. Similarly, hypocomplementemic urticarial vasculitis syndrome, an illness that has recently been considered a monogenic form of lupus by some researchers [ 52 ], does not have many descriptions related to infection.…”