Association of Mycobacterium avium subsp. paratuberculosis with Multiple Sclerosis in Sardinian Patients

Cossu, Davide; Cocco, Eleonora; Paccagnini, Daniela; Masala, Speranza; Ahmed, Niyaz; Frau, Jessica; Marrosu, Maria Giovanna; Sechi, Leonardo Antonio

doi:10.1371/journal.pone.0018482

Cited by 88 publications

(103 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The same molecular mimicry principle is suggested as the link between MAP (HSP65) and the organ-specific autoantigens of thyroiditis [76,77]. Also, a recent article implicate MAP in multiple sclerosis [78]. Molecular mimicry and SLC11A1 associations are germane here as well [79].…”

Section: Map and Other Autoimmune Disease-thyroiditis And Multiple Scmentioning

confidence: 74%

Mycobacterium avium subspecies paratuberculosis—An environmental trigger of type 1 diabetes mellitus

Dow¹

2012

JDM

View full text Add to dashboard Cite

Type 1 diabetes mellitus (T1DM) is an autoimmune disease. The etiology of T1DM is incompletely understood but environmental agent(s) are thought to trigger T1DM in the genetically at-risk. Humans are widely exposed to Mycobacterium avium subspecies paratuberculosis (MAP), a proven multi-host chronic enteric pathogen that is mostly studied in ruminant animals and causes the inflammatory disease paratuberculosis or Johne's disease. In humans, MAP is the putative cause of Crohn's disease and has been linked to sarcoidosis, autoimmune thyroiditis, multiple sclerosis and autoimmune diabetes. The role of MAP as a trigger for T1DM was first postulated in 2005; subsequent studies suggest a link. This article discusses MAP, human exposure to MAP, genetic susceptibility to MAP and MAP in human disease including T1DM.

show abstract

Section: Map and Other Autoimmune Disease-thyroiditis And Multiple Scmentioning

confidence: 74%

Mycobacterium avium subspecies paratuberculosis—An environmental trigger of type 1 diabetes mellitus

Dow¹

2012

JDM

View full text Add to dashboard Cite

show abstract

“…Another recent article implicates MAP in multiple sclerosis. Molecular mimicry and SLC11A1 associations are germane here as well (Cossu et al, 2011, Gazouli et al, 2008b.…”

Section: Map and Other Autoimmune Disease -Thyroiditis And Multiple Smentioning

confidence: 89%

Environmental Triggers of Type 1 Diabetes Mellitus – Mycobacterium Avium Subspecies Paratuberculosis

Dow¹,

Sechi²

2011

Type 1 Diabetes - Pathogenesis, Genetics and Immunotherapy

View full text Add to dashboard Cite

“…Recently our group reported MAP involvement in MS [1,2]. The association was postulated in light of the strong humoral response directed against two MAP specific proteins (MAP2694, MAPFprB), and the detection of MAP's DNA in the peripheral blood of MS patients.…”

Section: Discussionmentioning

confidence: 99%

“…We recently demonstrated that Mycobacterium avium subsp. paratuberculosis (MAP) is an environmental agent associated with MS in the Sardinian population [1,2]. The rate of MS in Sardinia is one of the highest worldwide [3], probably due to the particular genetic structure of Sardinian people.…”

Section: Introductionmentioning

confidence: 99%

Association of Mycobacterium avium subsp. paratuberculosis and SLC11A1 polymorphisms in Sardinian multiple sclerosis patients

Cossu

Masala

Cocco³

et al. 2013

J Infect Dev Ctries

Self Cite

View full text Add to dashboard Cite

Introduction: Recent findings propose that Mycobacterium avium subsp. paratuberculosis (MAP) infection could act as risk factor in favoring multiple sclerosis (MS) progression. SLC11A1 is a gene associated with mycobacterial survival in the host and it may be involved in the induction and maintenance of autoimmune disease. Methodology: In this preliminary study, 100 MS patients and 100 healthy controls (HCs) from Sardinia were enrolled. Eight single nucleotide polymorphisms (SNPs) in the SLC11A gene were searched by PCR RFLP-genotyping. IS900 specie specific PCR was undertaken to search for MAP presence. Indirect ELISA was performed to asses if MS patients displayed a stronger humoral response against MAP2694 protein compared to the HCs. Results: Only rs2276631 SNP was associated with MS. MAP DNA was detected in 23 out of 100 MS patients (23%) and in 7 out of 100 HCs (7%). A strong humoral response against MAP2694 protein was detected in 36% of MS patients and only in 3% of HCs. A correlation between ELISA sero-positivity and the rs2276631 SNP was also found. Conclusion: Our preliminary results suggest that the Sardinian population might be prone to develop autoimmune disease due to polymorphisms in immunomodulating the SLC11A1 gene, which is important in the immune response against intracellular bacteria such as MAP.

show abstract

Association of Mycobacterium avium subsp. paratuberculosis with Multiple Sclerosis in Sardinian Patients

Cited by 88 publications

References 19 publications

Mycobacterium avium subspecies paratuberculosis—An environmental trigger of type 1 diabetes mellitus

Mycobacterium avium subspecies paratuberculosis—An environmental trigger of type 1 diabetes mellitus

Environmental Triggers of Type 1 Diabetes Mellitus – Mycobacterium Avium Subspecies Paratuberculosis

Association of Mycobacterium avium subsp. paratuberculosis and SLC11A1 polymorphisms in Sardinian multiple sclerosis patients

Contact Info

Product

Resources

About