Association of Multivitamin and Mineral Supplementation and Risk of Cardiovascular Disease

Kim, Joon‐Seok; Choi, June-Seok; Kwon, Soo Young; McEvoy, John W.; Blaha, Michael J.; Blumenthal, Roger S.; Güallar, Eliseo; Zhao, Di; Michos, Erin D.

doi:10.1161/circoutcomes.117.004224

Cited by 55 publications

(31 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although DS are defined to supplement the diet under the Dietary Supplement Health and Education Act, four of the top five motivations for DS or MVM use were related to health promotion and disease prevention: “to maintain health,” “to improve overall health,” “to prevent colds,” and “to prevent health problems”. Our results supported that many DS users perceive supplements as “insurance” against health problems [ 30 , 31 , 32 ], although evidence of the health benefits of dietary supplements are controversial and complex [ 33 , 34 , 35 ]. DS use information of children aged <16 y was given by their proxies, so some motivations reported may be of parents or caregivers, not of children themselves.…”

Section: Discussionsupporting

confidence: 79%

Dietary Supplement Use among U.S. Children by Family Income, Food Security Level, and Nutrition Assistance Program Participation Status in 2011–2014

et al. 2018

View full text Add to dashboard Cite

This analysis characterizes use of dietary supplements (DS) and motivations for DS use among U.S. children (≤18 years) by family income level, food security status, and federal nutrition assistance program participation using the 2011–2014 National Health and Nutrition Examination Survey data. About one-third (32%) of children used DS, mostly multivitamin-minerals (MVM; 24%). DS and MVM use were associated with higher family income and higher household food security level. DS use was lowest among children in households participating in the Supplemental Nutrition Assistance Program (SNAP; 20%) and those participating in the Special Supplemental Nutrition Assistance Program for Women, Infants, and Children (WIC; 26%) compared to both income-eligible and income-ineligible nonparticipants. Most children who used DS took only one (83%) or two (12%) products; although children in low-income families took fewer products than those in higher income families. The most common motivations for DS and MVM use were to “improve (42% or 46%)” or “maintain (34 or 38%)” health, followed by “to supplement the diet (23 or 24%)” for DS or MVM, respectively. High-income children were more likely to use DS and MVM “to supplement the diet” than middle- or low-income children. Only 18% of child DS users took DS based on a health practitioner’s recommendation. In conclusion, DS use was lower among children who were in low-income or food-insecure families, or families participating in nutrition assistance programs.

show abstract

Section: Discussionsupporting

confidence: 79%

Dietary Supplement Use among U.S. Children by Family Income, Food Security Level, and Nutrition Assistance Program Participation Status in 2011–2014

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The most popular NS consumed by participants in this study was MVM, which was consistent with the result of the other researches [ 36 , 37 , 38 , 39 , 40 , 41 , 51 ]. Studies have shown that daily use of MVM reduced the risk of birth defects, coronary heart disease, colon cancer and breast cancer, and reduced the number of days of infectious disease in the elderly by 50% [ 33 , 52 ]. The use of Vitamin D supplements was in the top two of the current study, which is consistent with the high proportion of vitamin D inadequacy in China [ 49 , 56 ].…”

Section: Discussionmentioning

confidence: 99%

“…Omega-3 fatty acids were reported to have no protective effects on cardiovascular disease [ 27 , 28 ]. A meta-analysis demonstrated that the multi-vitamins and minerals (MVM) supplement did not make the cardiovascular outcomes better in the general population [ 33 ]. It was also reported that there was little to no scientific evidence that NS reduced cancer risk, even though it was partly believed that NS could ward off chronic disease [ 34 ].…”

Section: Introductionmentioning

confidence: 99%

Nutrient Supplement Use among the Chinese Population: A Cross-Sectional Study of the 2010–2012 China Nutrition and Health Surveillance

et al. 2018

View full text Add to dashboard Cite

Nutrient supplements play a key role in managing malnutrition/chronic diseases and are commonly used in the world, but few studies described the prevalence of nutrient supplement use at the national level in China. To our knowledge, this study provides the first detailed investigation of nutrient supplement use in a nationally representative sample of the Chinese population. This study aimed to describe the prevalence of the nutrient supplement use among the Chinese population aged 6 years or older in 2010–2012. A stratified multistage cluster sampling method was conducted to recruit participants from 150 surveillance sites. The demographic characteristics and information about nutrient supplement use were collected through an interview-administrative questionnaire. A total of 74,501 children and adults (excluding the pregnant women) were included in the study (mean age, 35.7 years; male, 47.0%, female, 53.5%). Only 0.71% of the participants reported using nutrient supplements in the previous month. Participants aged 6–11 years and 60 years and above, female, living in large urban, with higher education level and higher family incomes were more likely to use nutrient supplements than their counterparts (p < 0.05). The prevalence of nutrient supplement use increased with age in Chinese adults. The highest usage among the nutrient supplements was multi-vitamins and minerals with 0.37%. More females used single vitamin, multi-mineral, multi-vitamins and minerals than males (p < 0.05). The nutrient supplement use proportion was highest amongst the participants with a health problem, and the participants who had no idea about their health conditions were the least likely to use the nutrient supplements (p < 0.05). The prevalence of nutrient supplement use was low among the Chinese population in 2010–2012. Further research is required to understand the social cognition, usage reasons, dosage and consumption motivation of NS, and the relationships with health effects, to ensure that the nutrient supplements can be appropriately promoted in China.

show abstract

“…Interestingly, a diet rich in polyphenol powder, obtained from olive mill wastewater, enhanced antioxidant mechanisms and reduced oxidative stress-induced damage in chickens [33]. Moreover, in vitro treatment with hydroxytyrosol, or polyphenol extracts, from extra virgin olive oil, No prevention of heart attacks, strokes, or cardiovascular death [164] Reduced risk of CHD incidence 6 Oxidative Medicine and Cellular Longevity protects against the endothelial dysfunction induced by hyperglycemia and free fatty acids through modulation of NO production and endothelin-1 (ET-1) expression [34]. These observations have been confirmed by the NUTRAO-LEUM study, a randomized double-blind controlled trial, which supported the hypothesis of beneficial effects of virgin olive oils on biomarkers of endothelial dysfunction in healthy adults.…”

Section: Nutraceutical Supplementation For Atherosclerosis Preventionmentioning

confidence: 99%

“…A recent meta-analysis of 18 studies, which involved a total of 2 million participants, concluded that taking multivitamins does not prevent heart attacks, strokes, or cardiovascular death, even though it seems to be associated with a lower risk of CHD incidence [164]. In the absence of studies showing their efficacy in primary prevention of CVDs, the AHA does not recommend vitamin supplementation for healthy subjects, and similarly, the U.S. Preventive Services Task Force (USPSTF) states that the current evidence is insufficient (I) to assess the balance of benefits and harms of the use of multivitamins for the prevention of cardiovascular disease or cancer (I statement).…”

Section: 5mentioning

confidence: 99%

The Use of Nutraceuticals to Counteract Atherosclerosis: The Role of the Notch Pathway

Aquila

Marracino

Martino

et al. 2019

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Despite the currently available pharmacotherapies, today, thirty percent of worldwide deaths are due to cardiovascular diseases (CVDs), whose primary cause is atherosclerosis, an inflammatory disorder characterized by the buildup of lipid deposits on the inside of arteries. Multiple cellular signaling pathways have been shown to be involved in the processes underlying atherosclerosis, and evidence has been accumulating for the crucial role of Notch receptors in regulating the functions of the diverse cell types involved in atherosclerosis onset and progression. Several classes of nutraceuticals have potential benefits for the prevention and treatment of atherosclerosis and CVDs, some of which could in part be due to their ability to modulate the Notch pathway. In this review, we summarize the current state of knowledge on the role of Notch in vascular health and its modulation by nutraceuticals for the prevention of atherosclerosis and/or treatment of related CVDs.

show abstract

Association of Multivitamin and Mineral Supplementation and Risk of Cardiovascular Disease

Cited by 55 publications

References 53 publications

Dietary Supplement Use among U.S. Children by Family Income, Food Security Level, and Nutrition Assistance Program Participation Status in 2011–2014

Dietary Supplement Use among U.S. Children by Family Income, Food Security Level, and Nutrition Assistance Program Participation Status in 2011–2014

Nutrient Supplement Use among the Chinese Population: A Cross-Sectional Study of the 2010–2012 China Nutrition and Health Surveillance

The Use of Nutraceuticals to Counteract Atherosclerosis: The Role of the Notch Pathway

Contact Info

Product

Resources

About