Association of multiple sclerosis with restless legs syndrome and other sleep disorders in women

Li, Y.; Munger, KL; Batool-Anwar, Salma; Vito, Katerina De; Ascherio, Alberto; Gao, Xiang

doi:10.1212/wnl.0b013e3182553c5b

Cited by 60 publications

(44 citation statements)

References 38 publications

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“…In addition, Moreira et al (2008) found that RLS is significantly associated with sleep quality, sleep disturbances, and excessive daytime sleepiness (P = 0.02) (16). Moreover, Li et al (2012) reported that the prevalence of RLS and daytime sleepiness is significantly higher among women who suffer from MS and the risk of developing RLS in the future are higher in this group, as well (17). Therefore, due to the high prevalence of RLS and its' worsening effect on sleep quality, the assessment of RLS should be of great consideration in patients with MS.…”

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

“…Li et al (2012) also studied the association between RLS, other sleep disorders, and MS in a group of women. They reported that the prevalence of daytime sleepiness and RLS was significantly higher among women with MS (17). Given variations in RLS prevalence in different populations, this study was designed to investigate the association between RLS and sleep difficulties in a group of patients with MS.…”

Section: Introductionmentioning

confidence: 99%

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Is Sleep Quality Associated with Restless Legs Syndrome in Patients Suffering from Multiple Sclerosis?

et al. 2017

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Background: Restless legs syndrome (RLS) is a type of movement disorder with strong importunate movement of legs during rest or inactivity. Twitching of muscle is experienced at night that disturbs patients' sleep. This syndrome is more prevalent among patients with multiple sclerosis (MS). Hence, this study aimed to investigate the association between restless legs syndrome and sleep disturbances in patients suffering from MS. Methods: This cross-sectional study was conducted from May to September 2016 in Qazvin, Iran. Participants were 118 patients with MS referring to the multiple sclerosis association. Data were collected using a demographic questionnaire, expanded disability status scale (EDSS) to screen and assess the intensity of restless legs syndrome, and Pittsburgh sleep quality index to investigate sleep disturbance. Descriptive and inferential statistics including independent T test, 2 test, and stepwise logistic regression analysis were used for data analysis. Results: RLS was diagnosed in 56.8% of the participants. The score of sleep quality was above 6 indicating poor sleep quality in the patients. However, the mean score of PSQI was significantly higher in patients suffering from restless legs syndrome compared to

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Is Sleep Quality Associated with Restless Legs Syndrome in Patients Suffering from Multiple Sclerosis?

et al. 2017

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“…On the other hand, in CIDP, which is an inflammatory immune-mediated neuropathy, the longest lower limbs nerves may be more frequently affected by the inflammatory process. Supporting this hypothesis, the prevalence of RLS is increased in inflammatory disorders of central nervous system, such as multiple sclerosis, 25,26 of which CIDP can be considered the peripheral counterpart, with respect to clinical (relapsing or progressive disease course), pathological (focal demyelination and concomitant axon damage), and pathogenic features.…”

Section: 24mentioning

confidence: 95%

Restless Leg Syndrome in Different Types of Demyelinating Neuropathies: A Single-Center Pilot Study

Luigetti

Grande²,

Testani³

et al. 2013

Journal of Clinical Sleep Medicine

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The most common form is CMT1A, due to a duplication of a 1.4 MB region containing the gene encoding the peripheral myelin protein 22 (PMP22).9 CMT1A discloses a stereotypical sensorimotor, length-dependent neuropathy associated with marked and homogeneous slowing of nerve conduction velocities. 9 The deletion of the same chromosome 17 region causes hereditary neuropathy with liability to pressure palsy (HNPP), usually characterized by recurrent palsies due to trivial traumas. Objective: to determine the prevalence of restless legs syndrome (RLS) in a cohort of patients with demyelinating neuropathies. Methods: Patients were retrospectively recruited from our cohort of different forms of demyelinating neuropathies, including chronic infl ammatory demyelinating neuropathy (CIDP), Charcot-Marie-Tooth 1A (CMT1A), and hereditary neuropathy with liability to pressure palsies (HNPP) referred to our Department of Neurology in a 10-year period. The validated 4-item RLS questionnaire was used for diagnosis of RLS. All patients with RLS who fulfi lled criteria underwent a suggested immobilization test to confi rm the diagnosis. A group of outpatients referred to the sleep disorders unit and data from published literature were used as controls. Results: Prevalence of RLS in demyelinating neuropathy group was higher than prevalence observed in control population (p = 0.0142) or in the literature data (p = 0.0007). In particular, in comparison with both control population and literature data, prevalence of RLS was higher in CIDP group (p = 0.0266 and p = 0.0063, respectively) and in CMT1A group (p = 0.0312 and p = 0.0105, respectively), but not in HNPP (p = 1.000 and p = 0.9320, respectively). Conclusions: our study confi rms a high prevalence of RLS in infl ammatory neuropathies as CIDP and, among inherited neuropathies, in CMT1A but not in HNPP. Considering that this is only a small cohort from a single-center retrospective experience, the link between RLS and neuropathy remains uncertain, and larger multicenter studies are probably needed to clarify the real meaning of the association between RLS and neuropathy. Keywords: Restless leg syndrome (RLS), demyelinating neuropathies, chronic infl ammatory demyelinating neuropathy (CIDP), Charcot-Marie-Tooth 1A (CMT1A), hereditary neuropathy with liability to pressure palsies (HNPP), suggested immobilization test (SIT) Citation: Luigetti M; Del Grande A; Testani E; Bisogni G; Losurdo A; Giannantoni NM; Mazza S; Sabatelli M; Della Marca G. Restless leg syndrome in different types of demyelinating neuropathies: a single-center pilot study. J Clin Sleep Med 2013;9(9):945-949.

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“…RLS symptoms appear usually after the onset of MS (18)(19)(20)23,26,27). There is no relationship between MS subtypes and the presence of RLS (18,20,(22)(23)(24)(25)31).…”

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confidence: 99%

Restless legs syndrome in multiple sclerosis

Sorgun¹,

Aksun²,

Atalay³

et al. 2015

Turk J Med Sci

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IntroductionRestless legs syndrome (RLS) is a sleep disorder characterized by an urge to move the legs associated with uncomfortable paresthesias. Usually, the symptoms manifest in the evening or at night, when the patients take rest, and are relieved by walking or moving the legs (1). Diagnosis of RLS needs to involve the following clinical features: (a) uncomfortable and unpleasant sensations in the legs, (b) worsening of the symptoms during rest, (c) relief of the symptoms by movement, (d) exacerbation of the sensitive disturbance in the evening or at night (1). The majority of RLS cases are commonly classified as idiopathic and include sporadic and inherited forms. Secondary form of RLS has been associated with iron deficiency, renal failure, pregnancy, antidopaminergic therapy, rheumatoid arthritis, or several neurological disorders, including peripheral neuropathy, spinocerebellar ataxia, essential tremor, Parkinson disease, and myelopathies (2-4). The etiopathogenesis of RLS is unknown, yet there is increasing evidence of dopaminergic neurotransmission dysfunction (5-9).RLS prevalence has been reported to be 1.2%-15% and 12.12%-65.1% in the general population and in MS patients, respectively (10-30). RLS symptoms appear usually after the onset of 23,26,27). There is no relationship between MS subtypes and the presence of RLS (18,20,[22][23][24][25]31). There are only three studies that investigated the relationship between functional system involvement and the presence of RLS in MS patients (19,23,25). Two of them showed that there was a significant relationship between some functional system involvement and RLS (19,25). In contrast, Deriu et al. did not find any relationship between the presence of RLS and functional system involvement (23). Some studies suggested that the expanded disability status scale (EDSS) was not related to RLS in MS patients (22,23). However, other studies showed that EDSS score was higher in MS patients with RLS than in those without RLS (18)(19)(20)30).Lesion localization in brain MRI did not show any relationship with the presence of RLS in MS patients in most studies (18)(19)(20)22,23). There is only one study showing that MS patients with RLS (MS/RLS+) and patients without RLS (MS/RLS-) had similar cervical cord lesion load, but with less fractional anisotropy in cervical and brain MRI in the latter.Background/aim: There have been conflicting results in the literature regarding the relationship between functional system involvement, the expanded disability status scale (EDSS), and the presence of restless legs syndrome (RLS) in patients with multiple sclerosis (MS).Materials and methods: Ninety-one patients with MS and 40 patients in a control group (headache, essential tremor, and benign positional paroxysmal vertigo) were studied. The patients underwent a complete neurological examination and Kurtzke functional system scores were calculated. In order to assess the temporal relation between the onset of RLS and MS, a semistructured interview guided by a questionnaire about R...

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Association of multiple sclerosis with restless legs syndrome and other sleep disorders in women

Abstract: Women with MS had a significantly higher prevalence of RLS and daytime sleepiness and an increased risk of developing RLS in the future.

Cited by 60 publications

References 38 publications

Is Sleep Quality Associated with Restless Legs Syndrome in Patients Suffering from Multiple Sclerosis?

Is Sleep Quality Associated with Restless Legs Syndrome in Patients Suffering from Multiple Sclerosis?

Restless Leg Syndrome in Different Types of Demyelinating Neuropathies: A Single-Center Pilot Study

Restless legs syndrome in multiple sclerosis

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