Association of multiple blood metals with thyroid function in general adults: A cross−sectional study

Ye, Yanshi; Li, Ye; Ma, Qintao; Liu, Ying; Zeng, Huixian; Luo, Yaosheng; Liang, Yao; Liu, Lan; Liu, Lingling; Lin, Xu; Yu, Genfeng; Song, Cheng; Wan, Heng; Shen, Jie

doi:10.3389/fendo.2023.1134208

Cited by 8 publications

(4 citation statements)

References 42 publications

(56 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We did not find a significant association between Mg and thyroid function biomarkers, and the nutrient mixture model did not show that Mg makes a great contribution to the overall effect, which is consistent with the findings from previous studies. Cross-sectional studies found no significant association between Mg and thyroid hormones [37]. Only a severely low serum Mg level is associated with an increased risk of hypothyroidism [38].…”

Section: Effects Of Ca and Mg On Thyroid Functionmentioning

confidence: 97%

Assessment of Individual and Mixed Effects of Six Minerals on Thyroid Hormones in Chinese Pregnant Women

Gu,

Mo,

Chen

et al. 2024

Nutrients

View full text Add to dashboard Cite

The biosynthesis of thyroid hormones is essential for brain and neurological development. It requires iodine as a key component but is also influenced by other nutrients. Evidence for the combined nutrient status in relation to thyroid hormones during pregnancy is limited. We aimed to investigate the joint associations of iodine, selenium, zinc, calcium, magnesium and iron with maternal thyroid functions in 489 pregnant women from Hangzhou, China. Serum levels of six essential minerals and thyroid function parameters were measured during the first antenatal visit. Linear regression, quantile g-computation and Bayesian kernel machine regression were used to explore the individual and joint relationships between the six minerals and thyroid hormones. Linear regression analyses revealed that calcium was positively associated with free triiodothyronine (FT3). Zinc was positively associated with free thyroxine (FT4). Iodine was negatively associated with thyroid-stimulating hormone (TSH) and positively associated with FT3 and FT4. The quantile g-computation and BKMR models indicated that the joint nutrient concentration was negatively associated with TSH and positively associated with FT3 and FT4. Among the six minerals, iodine contributed most to thyroid function. The findings suggested that maintaining the appropriate concentration of minerals, either as individuals or a mixture, is important for thyroid health during pregnancy.

show abstract

Section: Effects Of Ca and Mg On Thyroid Functionmentioning

confidence: 97%

Assessment of Individual and Mixed Effects of Six Minerals on Thyroid Hormones in Chinese Pregnant Women

Gu,

Mo,

Chen

et al. 2024

Nutrients

View full text Add to dashboard Cite

show abstract

“…The levels of FT3, FT4, TSH, thyroid peroxidase antibodies (TPOAb), and thyroglobulin antibody (TgAb) in the serum were analyzed using the Microparticle Enzyme Immunoassay (MEIA) technique on the UniCel Dxi 800 Access instrument (Beckman Coulter, USA). We used the normal reference ranges for thyroid function and thyroid antibodies recommended by manufacturers: TSH (0.56-5.91 pmol/L), FT3 (3.53-7.37 pmol/L), FT4 (7.98-16.02 pmol/L), TPOAb (0-9 IU/ mL), and TgAb (0-4.9 IU/mL) (17,18). Fasting plasma glucose (FPG), 2-h postprandial plasma glucose (PPG), creatinine, serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured by the automatic biochemical analyzer AU5831 (Beckman Coulter, USA).…”

Section: Laboratory Testsmentioning

confidence: 99%

Sex-specific associations between the developmental alterations in the pituitary-thyroid hormone axis and thyroid nodules in Chinese euthyroid adults: a community-based cross−sectional study

Li,

Yu,

Yao

et al. 2024

Front. Endocrinol.

Self Cite

View full text Add to dashboard Cite

BackgroundPrevious studies have revealed the sex-specific features of pituitary–thyroid hormone (TH) actions and the prevalence of thyroid nodules (TNs) in children and adolescents. However, it was unclear in adults. We aimed to investigate the features of pituitary–TH actions in women and men at different ages, and the associations of thyrotropin (TSH), THs, and central sensitivity to THs indices including the thyroid feedback quantile-based index by FT4 (TFQIFT4) and the thyroid feedback quantile-based index by FT3(TFQIFT3) with of TNs in Chinese euthyroid adults.Methods8771 euthyroid adults from the communities in China were involved. Demographic, behavioral, and anthropometric data were gathered through the questionnaires. Ultrasound was performed to evaluate the TNs. TSH and THs levels were measured. The multivariable logistic regression and multivariable ordinal logistic regression were conducted.ResultsTFQIFT3 among both genders, except women aged 43 to 59 years, where it increased slightly. Additionally, there was an age-related decline in TFQIFT4 levels in both women and men at ages < 50 and < 53, respectively, but a marked increase after that. Lower TSH levels were significantly associated with a higher prevalence and lower odds of having fewer TNs using multiple nodules as the base category in both men and women (both P for trend < 0.05). Additionally, lower TFQIFT3 and TFQIFT4 levels were significantly associated with a higher prevalence of TNs in women (both P for trend < 0.05), and lower TFQIFT3 levels were significantly associated with a higher prevalence of TNs in men. Both higher TFQIFT3 and TFQIFT4 levels were significantly associated with higher odds of having fewer TNs using multiple nodules as the base category in women. However, the relationships between TFQIFT4 and the prevalence or number of TNs in men were not found.ConclusionsThe trends of THs, TSH, TFQIFT4, and TFQIFT3 at different ages were sex-dependent. Both TFQIFT4 and TFQIFT3 levels were negatively associated with the prevalence and number of TNs in women. The present results may lead to a better understanding of the sex-specific relationships between the development of the pituitary-TH axis and the formation of TNs.

show abstract

“…В исследовании, проведенном в Китае, Yanshi Ye и соавт. выявили связи следующих МЭ в крови: железа, цинка, меди, марганца между собой и с функцией ЩЖ [17]. Полученные нами данные согласуются с результатами исследования, проведенного в Алжире, где у 220 взрослых также выявили отрицательную связь между уровнем селена и показателями титра АТ-ТПО [18].…”

Section: сопоставление с другими публикациямиunclassified

Associations of thyroid status and thyroperoxidase antibodies with serum trace elements

Serikbayeva,

Tauesheva,

Shcherbakova

et al. 2023

Clin Exp Thyroid

View full text Add to dashboard Cite

BACKGROUND: Studies on the relationship between thyroid autoimmunity and serum trace elements (TE) are ongoing in different parts of the world, however, the data obtained are often contradictory, which determines the relevance of this study.AIM: The aim of the study was to identify associations between thyroid status and Anti-Thyroid Peroxidase antibodies (TPOAb) with serum TE among young women.MATERIALS AND METHODS: The study participants were 859 women aged 18–45, whose Thyroid-Stimulating Hormone (TSH) was in the reference range or above 3.4 µIU/ml and with free Thyroxine (fT4) in the reference range. The exclusion criteria were the presence of menopause and decompensation of chronic diseases. The participants were subdivided into 2 groups: a group of women with TPOAb less than 30 U/ml, designated as TPOAb(-), and a group of women with TPOAb more than 30 U/m, designated as TPOAb (+). The detection of TSH, fT4, and TPOAb in serum was provided by enzyme immunoassay on the Evolis Robotized System using “Thyroid — ELISA- TSH, 0.23–3.4 µIU/ml”, “Thyroid — ELISA free T4, 10–23.2 pmol/l”, “Thyroid ELISA — TPOAb<30 U/ml” test systems. The reference values were taken from the instructions of the manufacturer Alkor Bio group (Russia). Logistic regression analysis was applied to adjudge associations between TPOAb status and serum trace elements.RESULTS: The level of fT4 was lower in the AT-TPO (+) group compared to the AT-TPO (-), p=0.006; Triglycerides, aspartate aminotransferase, alkaline phosphatase was higher in the AT-TPO (+) group compared to the AT-TPO (-). There were more smoking women in the AT-TPO group (-) 4.1% versus 1.3% in AT-TPO (+). It was found that, after adjusting for likely cofounding factors, participants with antibody positivity had significantly lower concentrations of selenium; zinc, iodine, iron. When serum trace elements levels were analyzed in tertiles, the odds ratios TPOAb positivity of tertile 1 were higher that of tertile 3.CONCLUSION: The associations between TPOAb and microelements demonstrate their involvement in autoimmune processes in the thyroid gland.

show abstract

Association of multiple blood metals with thyroid function in general adults: A cross−sectional study

Cited by 8 publications

References 42 publications

Assessment of Individual and Mixed Effects of Six Minerals on Thyroid Hormones in Chinese Pregnant Women

Assessment of Individual and Mixed Effects of Six Minerals on Thyroid Hormones in Chinese Pregnant Women

Sex-specific associations between the developmental alterations in the pituitary-thyroid hormone axis and thyroid nodules in Chinese euthyroid adults: a community-based cross−sectional study

Associations of thyroid status and thyroperoxidase antibodies with serum trace elements

Contact Info

Product

Resources

About