2021
DOI: 10.1007/s10238-021-00747-3
|View full text |Cite
|
Sign up to set email alerts
|

Association of MTHFR and TYMS gene polymorphisms with the susceptibility to HCC in Egyptian HCV cirrhotic patients

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3

Citation Types

0
3
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
4
2

Relationship

1
5

Authors

Journals

citations
Cited by 6 publications
(3 citation statements)
references
References 53 publications
0
3
0
Order By: Relevance
“…Excessive cigarette smoking and heavy alcohol consumption are associated with low plasma folate concentration, and hyperhomocysteinemia among patients with chronic hepatitis C infection, which may accelerate the progression of liver fibrosis in hepatic patients and possibly lead to liver cancer [21,22]. MTHFR variant C667T has also been associated with an increased risk of invasive cervical cancer and premalignant lesions, which also indicate a possible role of MTHFR in viral infectionassociated cancers [23]. The purpose of this case-control study is to assess the existence of associations between the MTHFR C677T and A1298C polymorphisms and the risk of HCC.…”
Section: Introductionmentioning
confidence: 99%
“…Excessive cigarette smoking and heavy alcohol consumption are associated with low plasma folate concentration, and hyperhomocysteinemia among patients with chronic hepatitis C infection, which may accelerate the progression of liver fibrosis in hepatic patients and possibly lead to liver cancer [21,22]. MTHFR variant C667T has also been associated with an increased risk of invasive cervical cancer and premalignant lesions, which also indicate a possible role of MTHFR in viral infectionassociated cancers [23]. The purpose of this case-control study is to assess the existence of associations between the MTHFR C677T and A1298C polymorphisms and the risk of HCC.…”
Section: Introductionmentioning
confidence: 99%
“…An evaluation using liver biopsy usually shows hepatic steatosis and fibrosis as the most frequent histological changes [ 2 ]. Previous studies suggested HCV patients more easily to develop hepatic steatosis than those presenting with other liver diseases [ 3 , 4 ]. In turn, persistent hepatic steatosis increases the risk of hepatocellular carcinoma (HCC) [ 5 , 6 ], which highlights the need for early detection and clinical intervention.…”
Section: Introductionmentioning
confidence: 99%
“…Excessive cigarette smoking and heavy alcohol consumption are associated with low plasma folate concentration, and hyperhomocysteinemia among patients with chronic hepatitis C infection, which may accelerate the progression of liver brosis in CHC and possibly lead to liver cancer [19] [20]. MTHFR variant C667T has also been associated with an increased risk of invasive cervical cancer and premalignant lesions, which also indicate a possible role of MTHFR in viral infection-associated cancers [21]. The purpose of this case-control study is to assess the existence of associations between the MTHFR C677T and A1298C polymorphisms and the risk of HCC.…”
Section: Introductionmentioning
confidence: 99%