Association of MRS-Based Vertebral Bone Marrow Fat Fraction with Bone Strength in a Human In Vitro Model

Karampinos, Dimitrios C.; Ruschke, Stefan; Gordijenko, Olga; García, Eduardo Grande; Kooijman, Hendrik; Burgkart, Rainer; Rummeny, Ernst J.; Bauer, Jan; Baum, Thomas

doi:10.1155/2015/152349

Cited by 37 publications

(33 citation statements)

References 38 publications

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“…Theoretically, there are nine resonances in a typical marrow spectrum: CH 3 methyl protons (0.90 ppm), bulk CH 2 methylene protons (1.30 ppm), CH 2 methylene protons α‐ (2.25 ppm) and β‐ (1.59 ppm) to the carbonyl, methylene protons α to a double bond (2.03), diallylic CH 2 protons (2.77 ppm), glycerol (4.10–4.35 ppm), H 2 O (4.65 ppm), and olefinic protons (5.19–5.31 ppm). T 2 ‐corrected MRS spectra acquired from the third vertebra were exported and processed to estimate marrow FF by an MR physicist using the Advanced Method for Accurate, Robust and Efficient Spectral fitting of MRS data (AMARES) algorithm with use of prior knowledge in the jMRUI software (http://www.jmrui.eu).…”

Section: Methodsmentioning

confidence: 99%

“…Additionally, this procedure may result in bleeding or infection. Noninvasive methods for quantification of fatty marrow have been developed such as micro‐computed tomography (CT), dual‐energy CT, and magnetic resonance imaging (MRI) . Among these imaging methods, magnetic resonance spectroscopy (MRS) has been found to be safe and accurate and is generally considered as an adequate reference standard noninvasive technique for fat and metabolite quantification.…”

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confidence: 99%

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Comparison of chemical shift-encoded water-fat MRI and MR spectroscopy in quantification of marrow fat in postmenopausal females

Zheng

Gu³

et al. 2016

J. Magn. Reson. Imaging

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Purpose To validate a chemical shift‐encoded (CSE) water–fat imaging for quantifying marrow fat fraction (FF), using proton magnetic resonance spectroscopy (MRS) as reference. Materials and Methods Multiecho T2‐corrected MRS and CSE imaging with eight‐echo gradient‐echo acquisitions at 3T were performed to calculate marrow FF in 83 subjects, including 41 with normal bone mineral density (BMD), 26 with osteopenia, and 16 with osteoporosis (based on DXA). Eight participants were scanned three times with repositioning to assess the repeatability of CSE FF map measurements. Pearson correlation coefficient, Bland–Altman 95% limit of agreement, and Lin's concordance correlation coefficient were calculated. Results The Pearson correlation coefficient was 0.979 and Lin's concordance correlation coefficient was 0.962 between CSE‐based FF and MRS‐based FF. All data points, calculated using the Bland–Altman method, were within the limits of agreement. The intra‐ and interrater agreement for average CSE‐based FF was excellent (intrarater, intraclass correlation coefficient [ICC] = 0.993; interrater, ICC = 0.976–0.982 for different BMD groups). In the subgroups of varying BMD, inverse correlations were observed to be very similar between BMD (r = –0.560 to –0.710), T‐score (r = –0.526 to –0.747), and CSE‐based FF, and between BMD (r = –0.539 to –0.706), T‐score (r = –0.501 to –0.742), and MRS‐based FF even controlling for age, years since menopause, and body mass index. The repeatability for CSE FF map measurements expressed as absolute precision error was 1.45%. Conclusion CSE imaging is equally accurate in characterizing marrow fat content as MRS. Given its excellent correlation and concordance with MRS, the CSE sequence could be used as a potential replacement technique for marrow fat quantification. Level of Evidence: 1 J. Magn. Reson. Imaging 2017;45:66–73.

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Comparison of chemical shift-encoded water-fat MRI and MR spectroscopy in quantification of marrow fat in postmenopausal females

Zheng

Gu³

et al. 2016

J. Magn. Reson. Imaging

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“…More recently, several studies have strongly evidenced the role that also non-mineralised bone component potentially play in determining bone health (18,19). In particular, such studies stand that bone marrow, primarily consisting of adipocytes (yellow marrow areas) or adipocytes and haematopoietic red blood cells (red marrow areas), fills the cavities present at the trabecular bone level, and higher BMF fraction (BMFF) have been associated with lower BMD values (20,21,22,23,24,25,26). Moreover, in comparison to white and brown adipose tissue depots or ectopic fat depots in the human body, BMF exerts a distinctly different function, potentially playing an important role in the pathophysiology of metabolic disorders and fragility fracture risk (26).…”

Section: Obesitymentioning

confidence: 99%

DIAGNOSIS OF ENDOCRINE DISEASE: Evaluation of bone fragility in endocrine disorders

Eller-Vainicher

Falchetti

Gennari

et al. 2019

European Journal of Endocrinology

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An underlying disease affecting bone health is present in up to 40 and 60% of osteoporotic postmenopausal women and men respectively. Among the disorders leading to a secondary form of osteoporosis, the endocrine diseases are highly represented. A frequent finding in patients affected with an endocrine-related forms of bone disease is that the skeletal fragility is partially independent of the bone density, since the fracture risk in these patients is related more to a reduction of bone quality than to a decrease of bone mass. As a consequence, bone mineral density evaluation by dual-X-ray absorptiometry may be inadequate for establishing the risk of fracture in the setting of the endocrine-related forms of osteoporosis. In the recent years, several attempts to non-invasively estimating bone quality have been done. Nowadays, some new tools are available in the clinical practice for optimising the fracture risk estimation in patients with endocrine disorders. The aim of this review is to summarise the evidence regarding the role of the different imaging tools for evaluating bone density and bone quality in the most frequent forms of endocrine-related osteoporosis, such as obesity, diabetes, acromegaly, thyrotoxicosis, primary hyperparathyroidism, hypercortisolism and hypogonadism. For each of these disorders, data regarding both the current available tools and the future possible new techniques for assessing bone fragility in patients with endocrine diseases are reported.

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“…Summary of Most Important Effects Shown in Quantitative Bone Marrow MRI Studies of OsteoporosisJournal of Magnetic Resonance Imaging FAT FRACTION. Karampinos et al examined 10 vertebrae from human cadavers using single-voxel 1 H-MRS to assess vertebral bone marrow PDFF and compared these measurements with CT-based BMD and trabecular bone microstructure parameters, and biomechanically assessed vertebral bone strength 103. They reported significant correlations between the MRS-based PDFF and multidetector CT (MDCT)based parameters (up to r 5 -0.72), and between MRSbased fat PDFF and vertebral failure load (r 5 -0.77).…”

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confidence: 99%

Quantitative MRI and spectroscopy of bone marrow

Karampinos

Ruschke

Dieckmeyer

et al. 2017

Magnetic Resonance Imaging

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195

241

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Bone marrow is one of the largest organs in the human body, enclosing adipocytes, hematopoietic stem cells, which are responsible for blood cell production, and mesenchymal stem cells, which are responsible for the production of adipocytes and bone cells. Magnetic resonance imaging (MRI) is the ideal imaging modality to monitor bone marrow changes in healthy and pathological states, thanks to its inherent rich soft‐tissue contrast. Quantitative bone marrow MRI and magnetic resonance spectroscopy (MRS) techniques have been also developed in order to quantify changes in bone marrow water–fat composition, cellularity and perfusion in different pathologies, and to assist in understanding the role of bone marrow in the pathophysiology of systemic diseases (e.g. osteoporosis). The present review summarizes a large selection of studies published until March 2017 in proton‐based quantitative MRI and MRS of bone marrow. Some basic knowledge about bone marrow anatomy and physiology is first reviewed. The most important technical aspects of quantitative MR methods measuring bone marrow water–fat composition, fatty acid composition, perfusion, and diffusion are then described. Finally, previous MR studies are reviewed on the application of quantitative MR techniques in both healthy aging and diseased bone marrow affected by osteoporosis, fractures, metabolic diseases, multiple myeloma, and bone metastases. Level of Evidence: 3 Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2018;47:332–353.

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Association of MRS-Based Vertebral Bone Marrow Fat Fraction with Bone Strength in a Human In Vitro Model

Cited by 37 publications

References 38 publications

Comparison of chemical shift-encoded water-fat MRI and MR spectroscopy in quantification of marrow fat in postmenopausal females

Comparison of chemical shift-encoded water-fat MRI and MR spectroscopy in quantification of marrow fat in postmenopausal females

DIAGNOSIS OF ENDOCRINE DISEASE: Evaluation of bone fragility in endocrine disorders

Quantitative MRI and spectroscopy of bone marrow

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