Association of MRC-1 and IL-28Bwith the treatment outcome of hepatitis C: a case control study

Abstract

BackgroundThe aim of this study was to evaluate whether polymorphisms of the mannose receptor C type 1 (MRC-1) and interleukin 28B (IL-28B) genes are associated with the treatment outcome of patients infected with hepatitis C virus genotypes 1 and 2 (HCV-1 and HCV-2, respectively) who are treated with peginterferon plus ribavirin (PEG-IFNα-RBV).MethodsWe analyzed the association of the patients’ sustained viral responses (SVRs) to PEG-IFNα-RBV therapy with 2 single nucleotide polymorphisms (SNPs) in MRC-1 and 3 SNPs in IL-28B. We selected patients infected with either HCV-1 (n = 265) or HCV-2 (n = 195) with or without SVR.ResultsAmong the MRC-1 SNPs, rs691005 was found to be associated with SVR in HCV-1-infected patients (P < 0.0001). The IL-28B rs8099917 SNP was found to be associated with SVR in HCV-1- and HCV-2-infected patients (HCV-1, P < 0.0001; HCV-2, P = 0.002), while IL-28B rs955155 and rs10853728 SNPs were found to be associated with SVR in HCV-1-infected patients (P = 0.003) and HCV-2-infected patients (P = 0.02), respectively. We also identified an interaction between MRC-1 rs691005 and IL-28B rs8099917 (P = 0.001). The C-T haplotype was shown to have a positive effect on SVR in HCV-1-infected patients (OR = 1.77, 95% CI = 1.2, 2.62), whereas the T-G haplotype was shown to have a negative effect on SVR in HCV-1-infected patients (OR = 0.28, 95% CI = 0.14, 0.58).ConclusionsThese results suggest that SNPs of IL-28B and MRC-1 can be used as genetic markers for predicting the outcome of PEG-IFNα-RBV treatment of HCV infections.

Relationship between IL28B gene rs8099917 polymorphism and SVR in Turkish patients with hepatitis C virus genotype 1

“…These results are consistent with other studies, which presented similar results [29,36]. On the other hand, several studies reported mean HCV RNA level had a significantly higher in the carriers of rs8099917 G allele and the non-SVR group [22,27,32,35,40].…”

“…According to the previous results, the frequencies of T and G allele of rs8099917 polymorphism among the populations are distributed as 73.2% and 26.8% in Australian, 82% and 12% in Japanese, 81.8% and 18.2% in Slovakian, 70.2% and 29.8% in Brazilian, 92.3% and 7.7% in Chinese, respectively [4,22,28,34,35]. Moreover, in a multicenter study from Europe, Caucasian patients' allele frequencies were in 79% T allele and in 21% G allele [32].…”

“…This result was also very statistically significant. The SVR rates were higher in Asian populations than in the populations of Caucasian [35]. Asian and Caucasian patients with TT genotype had a 5.21-and a 2.54-fold greater chance of SVR than TT-negative patients [30].…”

Integrating Clinical Laboratory Measures and Icd-9 Code Diagnoses in Phenome-Wide Association Studies

“…AST levels are used for the diagnosis of various liver diseases like hepatitis and cirrhosis. In a recent study variants in MRC1 were reported to be associated with treatment outcomes for hepatitis C 24 .…”

The Effect of Wenxin Keli on the mRNA Expression Profile of Rabbits with Myocardial Infarction

“…MRC1 (mannose receptor, C type 1), a scavenger receptor mainly expressed in the membrane of macrophages, assists macrophages in recognizing and binding the high-mannose structures of potentially pathogenic viruses and bacteria, mediating the endocytosis and causing immune response [23]. Moreover, FPR1 (formyl peptide receptor 1) which belongs to the family of formyl peptide receptors can be activated by N-formyl peptides [24].…”