Association of Mouse Double Minute 2 -309T>G Polymorphism with Acute Myeloid Leukemia in an Iranian Population: A Case- Control Study

Abstract

Background: Genetic factors play a substantial role in acute myeloid leukemia (AML) etiology. Overexpression of the mouse double minute 2 (MDM2) gene has been explored in many tumors. However, the role of MDM2-309T>G (rs2279744) polymorphism in AML remains unclear. We have performed this study to examine the association of MDM2-309T>G with AML in an Iranian population. Methods: We have examined the association of N MDM2-309T>G polymorphism in 73 cases diagnosed with AML and 80 healthy controls by tetra-primer amplification refractory mutation system (ARMS) PCR assay. Odds ratios (OR) and 95% confidence intervals (CI) were calculated on the risk genotypes and alleles. Results: The TT, GG and GG genotypes of MDM2-309T>G polymorphism in patients were 32.9%, 23.2% and 43.9%, while in controls were 86.2%, 7.5% and 6.3%, respectively. Moreover, Frequency of mutant allele (G) was 55.6% in cases with AML and 10.0% in controls. The mutant homozygote genotype (GG) was associated with an increased susceptibility to AML (OR 1.471; 95% CI: 1.062-1.844; p=0.004). Conclusion: Our results showed that the MDM2-309T>G polymorphism was significantly associated with increased risk of AML in the Iranian population. Thus, the MDM2-309T>G polymorphism might be useful genetic susceptibility factors in the pathogenesis of AML.

Association Analysis of TP53 rs1042522, MDM2 rs2279744, rs3730485, MDM4 rs4245739 Variants and Acute Myeloid Leukemia Susceptibility, Risk Stratification Scores, and Clinical Features: An Exploratory Study

“…Regarding the risk for AML, Soleymannejad M et al [24] noticed an association between MDM2 rs2279744 and AML susceptibility. Also, Phillips CL et al [25] reported the same association on childhood AML patients and no association with treatment response [25].…”