Association of monocyte-to-high density lipoprotein ratio with arterial stiffness in patients with diabetes

Abstract

Background Previous studies proposed that chronic inflammation in diabetes has a role in abnormal collagen production and elastin degradation, which promotes arterial stiffness. Monocyte-to-High Density Lipoprotein cholesterol ratio (MHR) is a simple measurement associated with inflammation and oxidative stress. However, little is known about the relationship of MHR with arterial stiffness. This study aimed to determine the association of MHR with arterial stiffness in patients with diabetes. Methods A total of 81 patients with type 2 diabetes mellitus were enrolled in a cross-sectional study. Arterial stiffness factor in this study was Cardio Ankle Vascular Index (CAVI). We analyzed complete blood count and lipid profile in all participants, then performed statistical analysis to determine the relationship between MHR and CAVI. Receiver operating characteristic (ROC) analysis was used to estimate the cut-off values of MHR to predict CAVI ≥ 9. Results Median of MHR in this study was 11.91 with the mean of CAVI was 8.13 ± 0.93. Spearman correlation analysis revealed a significant positive correlation between MHR and CAVI (ρ = 0.239, p = 0.031). Multivariate analysis showed the independent association of MHR to arterial stiffness (β = 0.361, 95% CI 0.023–0.093) and to CAVI ≥ 9 (OR 1.181, 95% CI 1.047–1.332). The cut-off values of MHR for predicting CAVI ≥ 9 were identified as ≥ 13 (OR 3.289, 95% CI 1.036–10.441). Conclusion MHR is associated with CAVI in patients with diabetes, irrespective of various potential confounders.

Sex‐specific association between monocyte to high‐density lipoprotein cholesterol and extensive abdominal aortic calcification in humans

“…“Monocyte to high‐density lipoprotein cholesterol ratio (MHR)” has been proposed as an indicator of atherosclerotic severity via assessing the degree of dyslipidemia and inflammation (Kanbay et al, 2014). Previous studies have demonstrated its value in predicting multiple cardiovascular diseases (Chen et al, 2019; Mayasari et al, 2021; Wang et al, 2019; Zhan et al, 2020). Furthermore, a recent small sample study demonstrated that MHR could assess the occurrence and severity of AAC in peritoneal dialysis patients, but the value was lower than that of monocyte‐to‐lymphocyte ratio (MLR) (Sun et al, 2023).…”