Association of Monocyte to High-Density Lipoprotein Cholesterol Ratio with Carotid Artery Intima-Media Thickness in Patients with Systemic Lupus Erythematosus

Wang, Qian; Meng, Yan; Cao, Wenyan; Du, Weiwei; Liu, Yumei; Yan, Yi; Luo, Li; Ma, Xiumin

doi:10.2217/bmm-2016-0362

Cited by 15 publications

(13 citation statements)

References 20 publications

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“…Several studies indicated that high levels of HDL increased the risk of HT [12,13], while others observed no AGING association [14]. Recently, the monocyte to HDL cholesterol ratio (MHR), which combines proinflammatory and anti-inflammatory process, is found to be a novel prognostic marker of cardiovascular diseases [15], immune system diseases [16] and rheumatic disease [17]. However, evidence on the association between MHR and HT is limited.…”

Section: Introductionmentioning

confidence: 99%

The association between monocyte to high-density lipoprotein ratio and hemorrhagic transformation in patients with acute ischemic stroke

Wang

Cheng

Song

et al. 2020

Aging

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Hemorrhagic transformation (HT) is a common complication in patients with acute ischemic stroke. We investigated whether the monocyte to high-density lipoprotein ratio (MHR) is related to HT. Consecutive patients with ischemic stroke within 24 h of symptom onset were included in this study. HT was diagnosed by follow-up brain imaging after admission, and was classified as asymptomatic or symptomatic according to whether patients showed any neurologic worsening. Logistic regression was performed to estimate the association between MHR and HT. Of the 974 enrolled patients, 148 (15.2%) developed HT, and 24 (2.5%) patients experienced symptomatic HT. Compared to the highest MHR tertile (> 0.37), the lowest MHR tertile (< 0.22) was associated with 1.81-fold increase (95% CI 1.08-3.01, P = 0.024) in the odds of HT and 3.82-fold increase (95% CI 1.04-14.00, P = 0.043) in the odds of symptomatic HT after adjustment for possible confounders. Using a multivariate logistic regression model with restricted cubic spline, we found that elevated MHR was associated with a decreased risk of HT and symptomatic HT. In summary, lower MHR was independently associated with increased risk of HT and symptomatic HT in patients with ischemic stroke.

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Section: Introductionmentioning

confidence: 99%

The association between monocyte to high-density lipoprotein ratio and hemorrhagic transformation in patients with acute ischemic stroke

Wang

Cheng

Song

et al. 2020

Aging

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“…An association has been reported between MHR and many known safe markers of atherosclerosis. In this regard, Wang et al reported that MHR was associated with subclinical atherosclerosis and carotid intimamedia thickness (32). Moreover, Acikgöz et al suggested a relationship between MHR and flow-mediated dilatation (33).…”

Section: Discussionmentioning

confidence: 99%

Monocyte-to-High-Density Lipoprotein Ratio may be Related to the Coronary Artery Disease Reporting and Data System Score and Increased Left Ventricular Mass

Kadıyoran

Yılmaz

2022

Iran J Radiol

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Background: Activation of monocytes and lower high-density lipoprotein (HDL) levels accelerate atherosclerosis. The monocyte-to-HDL ratio (MHR) and the coronary artery disease-reporting and data system (CAD-RADS) score are recognized as proper indicators of the atherosclerotic process. Objectives: This study aimed to investigate the relationship between the CAD-RADS score and the left ventricular mass (LVM) and MHR and to evaluate the role of MHR as a predictive marker for the CAD-RADS score. Methods: In this study, the data of 160 patients, who underwent coronary computed tomography angiography (CCTA) for cardiac assessment in our radiology unit between January 2019 and January 2021, were collected and evaluated retrospectively. The CAD-RADS score, LVM, and MHR were calculated for the patients. Patients and Methods: The multivariate analysis showed independent relationships between CAD-RADS scores and high-sensitive C-reactive protein (hs-CRP) (β = 407, P < 0.001), MHR (β = 351, P < 0.001), age (β = 0.254, P < 0.001), male sex (β = 0.179, P < 0.001), and diabetes mellitus (β = 0.122, P = 0.008). The cutoff values of MHR (9.4 for CAD-RADS-1, 11.5 for CAD-RADS-2, 12.8 for CAD-RADS-3, and 14.0 for CAD-RADS-4) showed high sensitivity and specificity for the CAD-RADS scores. Conclusion: Based on the results, MHR may be associated with the CAD-RADS score and increased LVM. As an inexpensive and reliable test, MHR may be useful for the early diagnosis and follow-up of atherosclerotic heart diseases.

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“…Compared with single monocytes and HDL levels, combining monocytes and HDL to form a new comprehensive inflammatory index that incorporates both the injury mechanism and protection mechanism, namely the MHR, may have greater clinical value as this biomarker can reflect the degree of inflammation and oxidative stress. Many studies have shown that MHR is closely related to Parkinson's disease ( 53 ), ischemic stroke ( 54 ), cardiovascular disease ( 23 ), metabolic syndrome ( 55 ), immune system disease ( 26 ), and rheumatic disease ( 27 ). Related studies have also reported that the neutrophil-to-lymphocyte ratio (NLR) was related to disease activity at the onset of MS ( 56 ).…”

Section: Discussionmentioning

confidence: 99%

“…The monocyte to high-density lipoprotein ratio (MHR) is a novel marker that reflects the degree of inflammation and oxidative stress. Many studies have shown that the MHR is closely related to the occurrence, development, and prognosis of cardiovascular, cerebrovascular (23)(24)(25), immune system (26), and rheumatic diseases (27)(28)(29)(30). For example, one study found that the MHR was significantly higher in patients with multiple sclerosis than in healthy controls and that it was related to disease severity and disability, suggesting that the MHR may be used as an independent index to predict disability (31).…”

Section: Introductionmentioning

confidence: 99%

Monocyte to High-Density Lipoprotein Ratio: A Novel Predictive Marker of Disease Severity and Prognosis in Patients With Neuromyelitis Optica Spectrum Disorders

Zhang

Zhou

et al. 2021

Front. Neurol.

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Background and Purpose: To investigate the association of monocyte to high-density lipoprotein ratio (MHR) with disease severity and prognosis in patients with neuromyelitis optica spectrum disorders (NMOSD).Methods: This retrospective study included 125 patients with NMOSD. Demographic and clinical parameters, including the MHR, were assessed. The initial Expanded Disability Status Scale (EDSS) score and relapse rate were used to evaluate disease severity and prognosis, respectively. Correlations between MHR and disease severity and relapse rate were analyzed. The predictive value of MHR for prognosis was evaluated using receiver operating characteristic (ROC) curve analysis.Results: Compared with the low MHR group, the initial EDSS score (median 4.5 vs. 5.5%, P = 0.025) and relapse rate (51.61 vs. 30.16%, P = 0.015) were significantly higher in the high MHR group. MHR was positively correlated with the initial EDSS score (r = 0.306, P = 0.001). Multivariate analysis showed that MHR was significantly associated with severity (odds ratio = 7.90, 95% confidence interval [CI] = 1.08–57.82, P = 0.041), and it was a significant predictor of disease prognosis (hazard ratio = 3.12, 95% CI = 1.02–9.53, P = 0.046). The median relapse interval of the high MHR group was 24.40 months. When the MHR was higher than 0.565, the risk of relapse was high [sensitivity, 33.3%; specificity, 91.9%; area under the ROC curve, 0.642 (95% CI = 0.54–0.74, P = 0.007)].Conclusion: MHR is a novel predictive marker of disease severity and prognosis in patients with NMOSD. Early monitoring and reduction of MHR may allow earlier intervention and improved prognosis.

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Association of Monocyte to High-Density Lipoprotein Cholesterol Ratio with Carotid Artery Intima-Media Thickness in Patients with Systemic Lupus Erythematosus

Abstract: Our study suggests that the values of MHR could be a marker to assess carotid artery intima-media thickness in patients with SLE.

Cited by 15 publications

References 20 publications

The association between monocyte to high-density lipoprotein ratio and hemorrhagic transformation in patients with acute ischemic stroke

The association between monocyte to high-density lipoprotein ratio and hemorrhagic transformation in patients with acute ischemic stroke

Monocyte-to-High-Density Lipoprotein Ratio may be Related to the Coronary Artery Disease Reporting and Data System Score and Increased Left Ventricular Mass

Monocyte to High-Density Lipoprotein Ratio: A Novel Predictive Marker of Disease Severity and Prognosis in Patients With Neuromyelitis Optica Spectrum Disorders

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