Association of MMP2-1306C/T and TIMP2G-418C polymorphisms in retinal vein occlusion

Ortak, Hüseyin; Demir, Selim; Ateş, Ömer; Söğüt, Erkan; Alim, Sait; Benli, İsmail

doi:10.1016/j.exer.2013.06.009

Cited by 14 publications

(15 citation statements)

References 27 publications

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“…In a similar study, Ortak et al . reported that retinal vein occlusion might be associated with gene polymorphisms affecting the expression of MMP‐2 . MMPs constitute a large group of zinc‐dependent proteases responsible for the degrading and remodeling of extracellular matrix components, such as elastin and type IV collagen .…”

Section: Discussionmentioning

confidence: 99%

Polymorphism in dural arteriovenous fistula: matrix metalloproteinase‐2‐1306 C/T as a potential risk factor for sinus thrombosis

Tsuei

Chou

Chen

et al. 2018

Journal of Thrombosis and Haemostasis

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Background Dural arteriovenous fistula (DAVF) is a rare but important cerebrovascular disorder in adults. Little is known about the molecular genetic pathogenesis underlying DAVF development. Objectives To investigate the associations of gene polymorphisms and DAVF. Materials and Methods By the use of real-time PCR genotyping, seven single-nucleotide polymorphisms (SNPs) of angiogenesis-related genes were analyzed in 72 DAVF patients. Pertinent clinical and imaging data were subgrouped on the basis of location (cavernous sinus versus lateral sinus), lesions (single versus multiple), cerebral venous reflux (CVR) grading (Borden I versus Borden II/III), and sinus thrombosis (with versus without). Results We found that individuals carrying the polymorphic allele of matrix metalloproteinase (MMP)-2-1306 C/T (rs243865) had a significantly increased risk of sinus thrombosis in DAVF (odds ratio 6.2; 95% confidence interval 1.7-22.9). There was a weak difference in associations of tissue inhibitor of metalloproteinase (TIMP)-2 (rs2277698) gene polymorphism and DAVF patients subgrouped by CVR grading. Conclusions These preliminary results indicate that MMP-2-1306 C/T, but not MMP-9, TIMP-1, TIMP-2, and vascular endothelial growth factor A SNP variants, is a risk factor for the development of sinus thrombosis in DAVF patients.

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Section: Discussionmentioning

confidence: 99%

Polymorphism in dural arteriovenous fistula: matrix metalloproteinase‐2‐1306 C/T as a potential risk factor for sinus thrombosis

Tsuei

Chou

Chen

et al. 2018

Journal of Thrombosis and Haemostasis

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“…The probes for MMP2-1306C/T were Sensor 5′-ACC CAG CAC TCC ACC TCT TT-Fluo-3′/Anchor5′- LCRed-640-CTC TTC AGG TCT CAG CTC AGA AGT CAC TTC-Pho-3′; for TIMP2G-418C, they were Sensor 5′-CCC CGG GGT CCC TTC GAG-Fluo-3′/Anchor 5′- LCRed-640-CAG CCT CGG GGC GAG-Pho-3′. Synthesitisation were carried out by Metabion International AG (Martinsried, Deutschland) for both the primers and the fluorescent-labeled probes 17. PCR and melting curve analyses were carried out in 20 μl glass capillaries (Hoffmann-La Roche) 23.…”

Section: Methodsmentioning

confidence: 99%

Analysis of Mmp2-1306C/T and Timp2G-418C Polymorphisms with Relapsing Remitting Multiple Sclerosis

Aksoy

Ateş

Kurt

et al. 2016

Journal of Investigative Medicine

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“…Erythrocyte sedimentation rate seems more important in females and less important in branch RVO. While matrix metalloproteinase 2 gene variants appear to increase susceptibility to RVO, pro‐atherosclerotic inflammation‐related gene polymorphisms at the interleukin and tumour necrosis factor alleles have not been confirmed as independent risk factors . Treatment with systemic anti‐inflammatory agents has been inconclusive…”

Section: Pathophysiology and Risk Factorsmentioning

confidence: 99%

“…While matrix metalloproteinase 2 gene variants appear to increase susceptibility to RVO, pro-atherosclerotic inflammation-related gene polymorphisms at the interleukin and tumour necrosis factor alleles have not been confirmed as independent risk factors. [59][60][61] Treatment with systemic anti-inflammatory agents has been inconclusive. 62 Ocular hypertension is an important ophthalmic consideration in RVO.…”

Section: Pathophysiology and Risk Factorsmentioning

confidence: 99%

The ABCs of RVO: A review of retinal venous occlusion

MacDonald¹

2014

Clinical and Experimental Optometry

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Retinal vein occlusions are important causes of loss of vision; indeed, they are the second most common retinal vascular disease, following diabetic retinopathy. For this reason alone, primary eye-care providers must be well versed in diagnosis and management. Risk factors, though not universally agreed upon, include but are not limited to advancing age, systemic hypertension, arteriolarsclerosis, diabetes, hyperlipidaemia, blood hyperviscosity, thrombophilia, ocular hypertension and glaucoma. Typically, visual loss is secondary to macular oedema and/or retinal ischaemia. Treatment modalities have included observation, systemic thrombolysis and haemodilution, radial optic neurotomy, chorioretinal anastomosis, vitrectomy, laser photocoagulation and intravitreal injection of anti-inflammatory and, most recently, anti-vascular endothelial growth factors.

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Association of MMP2-1306C/T and TIMP2G-418C polymorphisms in retinal vein occlusion

Cited by 14 publications

References 27 publications

Polymorphism in dural arteriovenous fistula: matrix metalloproteinase‐2‐1306 C/T as a potential risk factor for sinus thrombosis

Polymorphism in dural arteriovenous fistula: matrix metalloproteinase‐2‐1306 C/T as a potential risk factor for sinus thrombosis

Analysis of Mmp2-1306C/T and Timp2G-418C Polymorphisms with Relapsing Remitting Multiple Sclerosis

The ABCs of RVO: A review of retinal venous occlusion

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