Association of MMP-2, MMP-3, and MMP-9 Polymorphisms with Susceptibility to Recurrent Pregnancy Loss

Behforouz, Athena; Dastgheib, Seyed Alireza; Abbasi, Hajar; Karimi-Zarchi, Mojgan; Javaheri, Atiyeh; Hadadan, Amaneh; Tabatabaei, Razieh Sadat; Meibodi, Bahare; Neámatzadeh, Hossein

doi:10.1080/15513815.2019.1710879

Cited by 9 publications

(9 citation statements)

References 33 publications

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“…Our findings confirm the results of Behforouz et al [23]. They have found a significant association between rs35068180 polymorphism of MMP3 gene and the pregnancy loss.…”

Section: Discussionsupporting

confidence: 93%

“…Results of our study referring to rs243865 MMP2 gene polymorphism after univariate analysis did not identify any significant relationship for genotype nor for allele distribution between cases and control. They agrees with the results of Behforouz et al [23], Pereza et al [27], and Ramu et al [28]. In contrast Li et al [19], showed that the polymorphism rs243865 were significantly associated with an increased susceptibility to recurrent miscarriages.…”

Section: Discussionsupporting

confidence: 90%

“…These observations were similar to the results presented by Li et al, and. Behforouz et al [19,23]. However, not all studies are in consistency with results of the present study.…”

Section: Discussionsupporting

confidence: 73%

“…Metalloproteinases belong to a large family of zinc-dependent endopeptidases that include collagenases (MMP1, MMP8, and MMP13), gelatinases (MMP2, MMP9), stromelysins (MMP3, MMP10), matrilysins (MMP7, MMP26), and transmembrane metalloproteinases types I and II. MMPs are crucial regulators of vascular and uterine remodeling and are involved in spiral artery formation and adhesion [23].…”

Section: Introductionmentioning

confidence: 99%

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Association between idiopathic recurrent pregnancy loss and genetic polymorphisms in cytokine and matrix metalloproteinase genes

et al. 2021

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Objectives: Recurrent reproductive loss (RPL) is a global health issue affecting a significant number of women. Approximately half of miscarriages have an unexplained etiology. Familial aggregation and twins studies prove that some cases of the RPL could have a genetic background. Recent evidences suggest that cytokines (e.g. IL-6, TNF alpha or TGF beta) and matrix metalloproteinases (MMP) are important for maintenance of pregnancy. Single gene polymorphisms (SNP), affecting these proteins production or their function may predispose to the loss of the pregnancy. The aim of this study was to evaluate the association between the following polymorphisms of IL6 (rs1800795), TNF (rs1800629), TGFB1 (rs1800471), MMP1 (rs1799750), MMP2 (rs2285053 and rs243865), MMP3 (rs35068180), MMP9 (rs3918242) and the recurrent pregnancy loss in polish population. Material and methods:Study subjects comprised of 67 patients with a history of recurrent pregnancy loss (≥ 2 miscarriages in history) and 75 controls. The distribution of genotypes for selected polymorphisms were determined by RFLP-PCR.Results: Maternal genotypes GG TNF, or 5A/5A MMP3 may be associated with the recurrent pregnancy loss. No association between the IL6, TGFB1, MMP1, MMP2, or MMP9 studied polymorphisms and the predisposition to miscarriage was found. Conclusions:This study demonstrated a possible association between rs1800629 TNF, rs35068180 MMP3 polymorphisms and recurrent pregnancy loss.

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“…Our findings confirm the results of Behforouz et al [23]. They have found a significant association between rs35068180 polymorphism of MMP3 gene and the pregnancy loss.…”

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 90%

“…These observations were similar to the results presented by Li et al, and. Behforouz et al [19,23]. However, not all studies are in consistency with results of the present study.…”

Section: Discussionsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

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Association between idiopathic recurrent pregnancy loss and genetic polymorphisms in cytokine and matrix metalloproteinase genes

et al. 2021

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“…Recurrent pregnancy loss (RPL) is one of the main public health issues with a rate of 5% among women of reproductive age ( 1 , 2 ) . RPL is defined as the loss of three or more successive pregnancies before viability and includes all pregnancy losses from the time of conception until 24 weeks of gestation ( 3 , 4 , 5 ) . The most commonly cited causes of miscarriage are structural chromosome abnormalities of one of the partners, uterine abnormalities, elevated random levels of homocysteine, and antiphospholipid syndrome ( 6 , 7 ) .…”

Section: Introductionmentioning

confidence: 99%

A meta-analysis of the association of the ACE I/D and PAI-1 4G/5G polymorphisms with recurrent pregnancy loss in Iranian women: Are the investigations adequate?

Dastgheib¹,

Karimi-Zarchi²,

Bahrami³

et al. 2021

tjod

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The associations of ACE I/D and PAI-1 4G/5G polymorphisms with recurrent pregnancy loss (RPL) in Iranian women have yielded controversial results. Thus, we conducted a meta-analysis to obtain more certain results. A comprehensive literature search was performed in the PubMed, Web of Sciences, Scopus, MedRxiv, SID, and CNKI databases up to January 1st, 2021, using the appropriate terms. All case-control studies were included. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the strength of associations. A total of 14 studies including eight studies with 783 patients and 761 healthy subjects on ACE I/D and six studies with 1.155 patients and 699 healthy subjects on PAI-1 4G/5G were included. Combined data revealed that ACE I/D polymorphism was significantly associated with RPL risk in Iranian women under three models i.e., allele [OR=0.744, 95% CI: (0.640-0.864); p≤0.001], dominant [OR=0.774, 95% CI: (0.601-0.996); p=0.047], and recessive [OR=0.767, 95% CI: (0.611-0.963); p=0.022]. Moreover, the pooled data showed a significant association between the PAI-1 4G/5G polymorphism and RPL risk under all five models i.e., allele [OR=2.352, 95% CI: (1.623-3.408); p≤0.001], heterozygote [OR=8.364, 95% CI: (4.744-14.756); p≤0.001), homozygote [OR=2.192, 95% CI: (1.093-4.394); p=0.027), dominant [OR=2.354, 95% CI: (1.309-4.235); p=0.004], and recessive [OR=5.208, 95% CI: (3.005-9.025); p≤0.001]. Stratification analysis revealed that these polymorphisms were associated with RPL risk by the number of miscarriages. Our pooled data indicated that ACE I/D and PAI-1 4G/5G polymorphisms were significantly associated with an increased risk of RPL in Iranian women. These significant findings showed that the investigation might be adequate for ACE I/D and PAI-1 4G/5G polymorphisms in the Iranian population.

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Screening of single nucleotide polymorphism in matrix metalloproteinase‐2 (MMP2) and tetraspanin CD63 genes in Chlamydia trachomatis‐infected tubal ectopic pregnancy patients

Pant,

Bhati,

Dimri

et al. 2024

Intl J Gynecology & Obste

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ObjectiveTubal ectopic pregnancy (EP) is a leading cause of maternal morbidity and mortality. Studies have suggested that infection‐induced inflammatory responses are major risk factors for EP. The aim of the present study was to find an association between MMP2 and CD63 gene variants and risk of EP during Chlamydia trachomatis infection in an Indian population.MethodsFallopian tube samples of 120 EP and 120 tubal ligation women were collected. C. trachomatis was detected by PCR. The genotyping of MMP2 (rs17859882 G/T, rs7201A/C) and CD63(rs2231464 C/T, rs376086542 A/G) gene variants was done by qualitative real‐time PCR using allelic discrimination method (VIC‐ and FAM‐labeled).ResultsThe frequency of GG or GT genotype of MMP2 G/T polymorphism (rs17859882) was 66.6% in infected EP and 36.7% in uninfected EP and 22% in tubal ligation controls (P < 0.0001), while the frequency of AC or CC genotype of MMP2 A/C polymorphism (rs7201) was 66.6% in infected EP and 20.6% in uninfected EP and 13.5% in tubal ligation controls (P < 0.0001). The frequency of CT or TT genotype of CD63 C/T polymorphism (rs2231464) was 74% in infected EP and 21.8% in uninfected EP and 11.8% tubal ligation controls (P < 0.0001), while the frequency of AG or GG genotype of CD63 A/G polymorphism (rs376086542) was 48.1% in infected EP and 41.3% in uninfected EP and 18.6% tubal ligation controls (P < 0.0001).ConclusionsThe present study revealed a strong association between the presence of gene variants MMP2 (rs17859882 G/T, rs7201A/C) and CD63 (rs2231464 C/T, rs376086542 A/G) and risk of tubal EP during C. trachomatis infection.

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Association of MMP-2, MMP-3, and MMP-9 Polymorphisms with Susceptibility to Recurrent Pregnancy Loss

Cited by 9 publications

References 33 publications

Association between idiopathic recurrent pregnancy loss and genetic polymorphisms in cytokine and matrix metalloproteinase genes

Association between idiopathic recurrent pregnancy loss and genetic polymorphisms in cytokine and matrix metalloproteinase genes

A meta-analysis of the association of the ACE I/D and PAI-1 4G/5G polymorphisms with recurrent pregnancy loss in Iranian women: Are the investigations adequate?

Screening of single nucleotide polymorphism in matrix metalloproteinase‐2 (MMP2) and tetraspanin CD63 genes in Chlamydia trachomatis‐infected tubal ectopic pregnancy patients

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