Association of MMP - 12 polymorphisms with severe and very severe COPD: A case control study of MMPs - 1, 9 and 12in a European population

Haq, Imran Ul; Chappell, Sally; Johnson, Simon R.; Lotya, Juzer; Daly, Leslie; Morgan, Kevin; Guetta-Baranés, Tamar; Roca, Josep; Rabinovich, Roberto; Millar, Ann; Donnelly, Seamas C.; Keatings, Vera M.; MacNee, William; Stolk, Jan; Hiemstra, Pieter S.; Miniati, Massimo; Monti, Simonetta; O'connor, Clare M.; Kalsheker, Noor

doi:10.1186/1471-2350-11-7

Cited by 74 publications

(70 citation statements)

References 32 publications

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“…However, the IL1B gene was not found to be a candidate gene for COPD in recent genome-wide association studies (GWAS) (Soler Artigas et al, 2012). This may be because the most recent GWAS were performed in Northern European populations (Todd et al, 2011); some single-nucleotide polymorphisms may have been significant but did not reach the genome-wide significant level for the GWAS (Haq et al, 2010). Thus, the lack of GWAS results may not rule out the involvement of polymorphisms in the IL1B gene with COPD.…”

Section: Introductionmentioning

confidence: 68%

Association of interleukin-1β -511C/T promoter polymorphism with COPD risk: a meta-analysis

Wang

Liu²,

Xu³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Studies examining the role of interleukin (IL)-1β -511C/ T promoter polymorphism in the pathogenesis of chronic obstructive pulmonary disease (COPD) have shown inconsistent results. This metaanalysis was performed to assess the association between the IL-1β -511C/T promoter polymorphism and COPD susceptibility. Published case-control, cross-sectional, and cohort studies from Pubmed, Embase, and China National Knowledge Infrastructure databases were retrieved. Data were extracted and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Twelve studies with 1692 cases and 2009 controls were included in this meta-analysis. Pooled effect size showed an overall but not significantly decreased risk of IL-1β -511 C/T with COPD susceptibility (OR = 0.89, 95%CI = 0.78-1.01) in a complete overdominant genetic model (TT+CC vs CT), indicating that homozygous individuals (CC and TT) have a decreased risk for COPD compared with heterozygotes (2015) (CT). In subgroup analysis by ethnicity, IL-1β -511C/T was significantly correlated with a decreased risk of COPD in Asians (OR = 0.73, 95%CI = 0.60-0.88, P = 0.001), but not in Caucasians (OR = 1.02, 95%CI = 0.83-1.24, P = 0.46), confirming a protective role of IL-1β -511C/T in COPD in Asians. Moreover, after excluding studies that included populations not in Hardy-Weinberg equilibrium, the pooled results were robust and no publication bias was observed. This meta-analysis suggests that the IL-1β -511C/T promoter polymorphism deceases the risk of COPD in Asians.

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Section: Introductionmentioning

confidence: 68%

Association of interleukin-1β -511C/T promoter polymorphism with COPD risk: a meta-analysis

Wang

Liu²,

Xu³

et al. 2015

Genet. Mol. Res.

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“…However, the GC gene was not identified as a candidate gene for COPD in recent genome-wide association studies (GWAS) (Artigas et al, 2012). This may be because most recent GWAS were performed in Northern European populations (Todd et al, 2011) and single-nucleotide polymorphisms may have been significant but did not reach a genome-wide level of significance (Haq et al, 2010). Thus, it remains unclear whether GC polymorphisms are associated with COPD risk.…”

Section: Introductionmentioning

confidence: 81%

Dual role of vitamin D-binding protein 1F allele in chronic obstructive pulmonary disease susceptibility: a meta-analysis

et al. 2015

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ABSTRACT. Vitamin D-binding protein (DBP), a highly polymorphic serum protein, encoded by GC gene, is important in the development of chronic obstructive pulmonary disease (COPD). This meta-analysis was performed to assess the association between GC polymorphisms (1F, 1S, and 2 alleles) and COPD susceptibility. Published case-control studies were retrieved from the Pubmed, Embase, and China National Knowledge Infrastructure databases. After data extraction, pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Seven case-control studies were included. Pooled effect size showed that GC polymorphisms were not significantly associated with COPD susceptibility. According to ethnicity, the 1F allele was significantly correlated with COPD susceptibility in Asians (1F vs 1S, OR: 1.52, 95%CI: 1.16-2.00 and 1F vs 2, OR: 1.87, 95%CI: 1.42-2.44), indicating that individuals with the 1F allele have an increased risk of COPD compared to those with the 1S or 2 allele. However, the 1F allele was associated with a lower, insignificant risk of COPD than the 1S and 2 alleles in Caucasians (1F vs 1S, OR: 0.83, 95%CI: 0.64-1.08 and 1F vs 2, OR: 0.73, 95%CI: 0.54-0.98). Moreover, no significant association was found for the 1S and 2 alleles in Asians (OR: 1.23, 95%CI: 0.90-1.69) and Caucasians (OR: 0.89, 95%CI: 0.70-1.13). After excluding each study, the pooled results were robust and no publication bias was observed. We found that the GC 1F allele confers a risk of COPD in Asians, whereas the 1F allele may protect against COPD in Caucasians.

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“…Mechanical properties also differ between healthy and diseased lungs 23,62 . For example, expression of matrix metalloproteinases and lysyl oxidase, which control degradation and crosslinking of collagens, respectively, are altered in various lung diseases including COPD and pulmonary fibrosis [63][64][65][66][67] . In diseased lungs, certain lineages of progenitors for lung endothelial and epithelial cells are depleted 68 .…”

Section: Discussionmentioning

confidence: 99%

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Mammoto

2014

JoVE

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Recent significant advances in stem cell research and bioengineering techniques have made great progress in utilizing biomaterials to regenerate and repair damage in simple tissues in the orthopedic and periodontal fields. However, attempts to regenerate the structures and functions of more complex three-dimensional (3D) organs such as lungs have not been very successful because the biological processes of organ regeneration have not been well explored. It is becoming clear that angiogenesis, the formation of new blood vessels, plays key roles in organ regeneration. Newly formed vasculatures not only deliver oxygen, nutrients and various cell components that are required for organ regeneration but also provide instructive signals to the regenerating local tissues. Therefore, to successfully regenerate lungs in an adult, it is necessary to recapitulate the lung-specific microenvironments in which angiogenesis drives regeneration of local lung tissues. Although conventional in vivo angiogenesis assays, such as subcutaneous implantation of extracellular matrix (ECM)-rich hydrogels (e.g., fibrin or collagen gels or Matrigel -ECM protein mixture secreted by Engelbreth-Holm-Swarm mouse sarcoma cells), are extensively utilized to explore the general mechanisms of angiogenesis, lung-specific angiogenesis has not been well characterized because methods for orthotopic implantation of biomaterials in the lung have not been well established. The goal of this protocol is to introduce a unique method to implant fibrin gel on the lung surface of living adult mouse, allowing for the successful recapitulation of host lung-derived angiogenesis inside the gel. This approach enables researchers to explore the mechanisms by which the lung-specific microenvironment controls angiogenesis and alveolar regeneration in both normal and pathological conditions. Since implanted biomaterials release and supply physical and chemical signals to adjacent lung tissues, implantation of these biomaterials on diseased lung can potentially normalize the adjacent diseased tissues, enabling researchers to develop new therapeutic approaches for various types of lung diseases. Video LinkThe video component of this article can be found at

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Association of MMP - 12 polymorphisms with severe and very severe COPD: A case control study of MMPs - 1, 9 and 12in a European population

Cited by 74 publications

References 32 publications

Association of interleukin-1β -511C/T promoter polymorphism with COPD risk: a meta-analysis

Association of interleukin-1β -511C/T promoter polymorphism with COPD risk: a meta-analysis

Dual role of vitamin D-binding protein 1F allele in chronic obstructive pulmonary disease susceptibility: a meta-analysis

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

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