Association of mitral annular calcification with endothelial dysfunction, carotid intima-media thickness and serum fetuin-A: an observational study

Zıyrek, Murat; Tayyareci, Yelda; Yurdakul, Selen; Şahin, Şükrü; Yıldırımtürk, Özlem; Aytekin, Saide

doi:10.5152/akd.2013.235

Cited by 13 publications

(10 citation statements)

References 29 publications

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“…As a known fact, in the pathophysiology of atherosclerotic cardiovascular diseases, increased inflammation, and endothelial dysfunction play fundamental roles [26]. Outcomes of this study suggest that NLR may be one of the markers of endothelial dysfunction, and inflammation in obese patients.…”

Section: Discussionmentioning

confidence: 80%

Neutrophil lymphocyte ratio in obese adolescents

Aydın

Yılmaz

Donma

et al. 2015

North Clin Istanbul

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OBJECTIVE:Obesity is a growing health problem in most of the developed countries. It is associated with many chronic diseases, affecting particularly endocrine and cardiovascular systems. Inflammation plays a key role in pathophysiology of obesity. In this study, we aimed to investigate the inflammation status in obese children using neutrophil/lymphocyte ratio.METHODS:In this study 130 obese and 57 healthy children were assessed retrospectively. According to Centers for Disease Control 2000 (CDC) BMI percentiles for childhood and adulthood, 85–95 percentile was considered as overweight and >95 percentile as obese.RESULTS:Lymphocyte/neutrophil ratios in the obese group were significantly higher compared to those in healthy controls (p=0.03 and p=0.045, respectively). Neutrophil/lymphocyte ratio and CRP level in the obese group were significantly higher compared to those in healthy controls (p=0.02 and p=0.00, respectively). Thrombocyte/lymphocyte ratios were not significantly different between two groups (p=0.156).CONCLUSION:It is possible that childhood obesity which has been increasingly prevalent recently triggers the pathogenesis of atherosclerosis during the early years of life. Increased neutrophil/lymphocyte ratio might be associated with the severity of inflammation which plays a role in the early stages of atherosclerosis. Therefore, taking childhood obesity under control using diet and other treatment methods will prevent mortality and morbidity in the elderly.

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Section: Discussionmentioning

confidence: 80%

Neutrophil lymphocyte ratio in obese adolescents

Aydın

Yılmaz

Donma

et al. 2015

North Clin Istanbul

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“…Furthermore, decreased serum fetuin-A and albumin levels are associated with the development of coronary artery disease and heart valve calcification505152535455565758. Therefore, the risk factors of atherosclerosis and heart valve calcification are identical to those promoting the formation of CPB in the human blood.…”

Section: Discussionmentioning

confidence: 99%

Apoptosis-mediated endothelial toxicity but not direct calcification or functional changes in anti-calcification proteins defines pathogenic effects of calcium phosphate bions

Kutikhin

Великанова

Mukhamadiyarov

et al. 2016

Sci Rep

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Calcium phosphate bions (CPB) are biomimetic mineralo-organic nanoparticles which represent a physiological mechanism regulating the function, transport and disposal of calcium and phosphorus in the human body. We hypothesised that CPB may be pathogenic entities and even a cause of cardiovascular calcification. Here we revealed that CPB isolated from calcified atherosclerotic plaques and artificially synthesised CPB are morphologically and chemically indistinguishable entities. Their formation is accelerated along with the increase in calcium salts-phosphates/serum concentration ratio. Experiments in vitro and in vivo showed that pathogenic effects of CPB are defined by apoptosis-mediated endothelial toxicity but not by direct tissue calcification or functional changes in anti-calcification proteins. Since the factors underlying the formation of CPB and their pathogenic mechanism closely resemble those responsible for atherosclerosis development, further research in this direction may help us to uncover triggers of this disease.

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“…NLR, considered to be an indicator of subclinical inflammation, is an indicator which is calculated by using neutrophil and lymphocyte values in the hemogram and of which popularity is increasing with each passing day (25). Increased inflammation and endothelial dysfunction play an important role in the pathophysiology of atherosclerotic cardiovascular diseases (26). Aydın et al (27) found out that NLR was higher in obese adolescents than the healthy control group.…”

Section: Discussionmentioning

confidence: 99%

The Assessment of the Neutrophil-lymphocyte Ratio and Platelet-lymphocyte Ratio in Dyslipidemic Obese Children

Dilek¹,

Gayret²,

Kılınç³

et al. 2019

BMB

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Childhood obesity is one of the most important children's health problems that is gradually increasing all over the world. Dyslipidemia which coexists with obesity is a risk factor for atherosclerotic diseases in adulthood. In this study, the usability of the neutrophil-lymphocyte ratio (NLR) and the platelet-lymphocyte ratio (PLR) in predicting dyslipidemia, a serious complication of obesity, in children were investigated. Method: Two hundred and seven cases aged between 11-17 years who were diagnosed with obesity at the Pediatrics Clinic of our hospital and 50 cases with no disorders whose complete blood count was performed for routine purposes were retrospectively investigated. The genders, ages, and examination findings of the cases were recorded. In obese children, leukocyte, hemoglobin, platelet, mean platelet volume, neutrophil and lymphocyte levels were evaluated in the complete blood count performed at the first admission. The NLR and the PLR were calculated. Preprandial blood glucose and preprandial insulin, serum aminotransferase values, and the lipid profile were recorded. Results: While dyslipidemia was determined in 99 (47.82%) of 207 cases who were diagnosed with obesity, it was not determined in 108 (52.18%) cases. The systolic blood pressure, diastolic blood pressure, and preprandial insulin level were higher in cases with dyslipidemia than the group without dyslipidemia. The PLR average of the dyslipidemic group was 112.75±39.11, the PLR average of the non-dyslipidemic group was 104.78±31.38, and the PLR average of the control group was 110.20±39.35, and there was no statistically significant difference between the PLR averages of the groups (p=0.353). The NLR average was 1.52±0.69 in Amaç: Çocukluk çağı obezitesi tüm dünyada giderek artan en önemli çocuk sağlığı sorunlarından biridir. Obezite ile birlikte olan dislipidemi, erişkin dönemde aterosklerotik hastalıklar için bir risk faktörüdür. Bu çalışmada çocuklarda, obezitenin ciddi bir komplikasyonu olan dislipidemiyi öngörmede nötrofil-lenfosit oranı (NLO) ve platelet-lenfosit oranının (PLO) kullanılabilirliğini araştırdık. Yöntem: Hastanemiz Çocuk Sağlığı ve Hastalıkları Kliniği'nde obezite tanısı alan 11-17 yaş arası 207 olgu ve herhangi bir rahatsızlığı olmayıp rutin amaçlı tam kan tahlili yapılan 50 olgu retrospektif olarak incelendi. Olguların cinsiyetleri, yaşları, muayene bulguları kaydedildi. Obez çocuklarda ilk başvuruda alınan tam kan sayımında lökosit, hemoglobin, trombosit, ortalama trombosit hacmi, nötrofil ve lenfosit düzeyleri değerlendirildi. NLO ve PLO hesaplandı. Açlık kan şekeri ve açlık insülin, serum aminotransferaz değerleri ve lipid profili kaydedildi. Bulgular: Obezite tanısı alan 207 olgunun 99'unda (%47,82) dislipidemi saptanırken, 108 olguda (%52, 18) dislipidemi saptanmadı. Dislipidemi saptanan olguların sistolik kan basıncı, diastolik kan basıncı ve açlık insülin düzeyi dislipidemi olmayan gruptan daha yüksekti. Dislipidemik grubun PLO ortalaması 112,75±39, 11, dispidemik olmayan grubun PLO ortalaması 104,78±31,38,...

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Association of mitral annular calcification with endothelial dysfunction, carotid intima-media thickness and serum fetuin-A: an observational study

Cited by 13 publications

References 29 publications

Neutrophil lymphocyte ratio in obese adolescents

Neutrophil lymphocyte ratio in obese adolescents

Apoptosis-mediated endothelial toxicity but not direct calcification or functional changes in anti-calcification proteins defines pathogenic effects of calcium phosphate bions

The Assessment of the Neutrophil-lymphocyte Ratio and Platelet-lymphocyte Ratio in Dyslipidemic Obese Children

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