Association of mitochondrial dysfunction and lipid metabolism with type 2 diabetes mellitus: A review of literature

Haghani, Karimeh; Asadi, Pouyan; Taheripak, Gholamreza; Noori-Zadeh, Ali; Darabi, Shahram; Bakhtiyari, Salar

doi:10.1007/s11515-018-1521-3

Cited by 2 publications

(1 citation statement)

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“…Insulin resistance is a major pathogenic factor of T2DM. Insulin maintains glucose homeostasis as an effective regulator of glucose metabolism (14). Insulin resistance means the reduced sensitivity of tissues to insulin-mediated biologic activity (15), which will result in increased adverse events such as obesity, hypertension, and dyslipidemia in patients with T2DM (16).…”

Section: Introductionmentioning

confidence: 99%

MiR-21 antagomir improves insulin resistance and lipid metabolism disorder in streptozotocin-induced type 2 diabetes mellitus rats

Wang¹,

Yang²,

Yang³

et al. 2020

Ann Palliat Med

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Background: Type 2 diabetes mellitus (T2DM) is a major cause of death with an increasing incidence at an epidemic rate. The existing treatments for T2DM lack long-term effective blood glucose control. In this study, the effects of miR-21 antagomir on T2DM and the related mechanism were investigated using streptozotocin (STZ)-induced T2DM rats.Methods: 30 T2DM rats were randomly divided into 3 groups (n=10): T2DM group, T2DM rats with miR-21 antagomir group, T2DM rats with NC antagomir group. The expression of miR-21 in rats was detected by qRT-PCR. blood glucose, triacylglycerol (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-Cho), insulin, adiponectin, ITT and GTT were detected. The expression of TIMP3 in si-TIMP3 rats and the expression of TIMP3 in T2DM rats with miR-21 antagomir and si-TIMP3 was detected by Western blotting.Results: We found that miR-21 antagomir reduced blood glucose concentration in T2DM rats. MiR-21 antagomir improved lipid metabolic disorder by decreasing the levels of triacylglycerol (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-Cho) and increasing the level of high-density lipoprotein cholesterol (HDL-Cho). Also, miR-21 antagomir reduced the value of homeostasis model assessment of insulin resistance (HOMA-IR), hemoglobin A1c (HbAc1), plasma insulin, and up-regulated the plasma adiponectin. These results, combined with insulin tolerance tests (ITT) and glucose tolerance tests (GTT) results, showed that miR-21 improved insulin resistance in STZ-induced T2DM rats. Then the target relationship between miR-21 and tissue inhibitor of metalloproteinases 3 (TIMP3) was proved by luciferase reporter assay. More impressively, miR-21 significantly increased the expression level of TIMP3 in STZ-induced T2DM rats. Conclusion:Our study taken together has shown that miR-21 antagomir improved insulin resistance and lipid metabolism disorder in STZ-induced T2DM rats by up-regulating the expression level of TIMP3. This study suggested that miR-21 antagomir could be used as an effective therapeutic strategy and the underlying mechanism was revealed.

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Section: Introductionmentioning

confidence: 99%