Association of miR-193b Down-regulation and miR-196a up-Regulation with Clinicopathological Features and Prognosis in Gastric Cancer

Mu, Yongping; Tang, Song; Sun, Wenjie; Gao, Weimin; Mao, Wang; Su, Xiulan

doi:10.7314/apjcp.2014.15.20.8893

Cited by 36 publications

(30 citation statements)

References 62 publications

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“…Yang et al (7) demonstrated that miRNA-193b was able to suppress breast cancer progression. Mu et al (26) reported that the downregulation of miR-193b may be used as a novel and promising prognostic marker in gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

Deregulation of miR-193b affects the growth of colon cancer cells via transforming growth factor-β and regulation of the SMAD3 pathway

Zhao

et al. 2017

Oncology Letters

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MicroRNA-193b (miRNA-193b) is often differentially expressed and is an important regulator of gene expression in colon cancer. The aim of the present study was to determine whether miRNA-193b affects cell growth in colon cancer and to investigate the potential underlying mechanisms. Patients with colorectal cancer (CRC; n=20) and healthy volunteers (n=10) were enrolled from the Department of Gastrointestinal Surgery Center, First Affiliated Hospital of Sun Yat-Sen University (Guangzhou, China). Western blot analysis was used to evaluate the protein expression of SMAD3 and transforming growth factor-β (TGF-β) in the patient samples. It was determined that miRNA-193b expression was markedly elevated in the CRC tissue samples. Furthermore, silencing of miRNA-193bin SW620 CRC cells by specific inhibitors significantly reduced the cell proliferation and induced apoptosis. In addition, the downregulation of miRNA-193b significantly activated the protein expression of SMAD3 and TGF-β, and promoted caspase-3 activity in SW620 cells. The results of the present study suggested that the deregulation of miRNA-193b may affect cell growth in colon cancer via the TGF-β and SMAD3 signaling pathways.

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Section: Discussionmentioning

confidence: 99%

Deregulation of miR-193b affects the growth of colon cancer cells via transforming growth factor-β and regulation of the SMAD3 pathway

Zhao

et al. 2017

Oncology Letters

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“…De Novo [360,[369][370][371][372][373][374][375][376][377][378][379][380][381][382][383] Starker Konsens (100 %)…”

Section: Level Of Evidence 2amentioning

confidence: 99%

“…Allerdings geht daraus nicht hervor, dass diese Marker zuverlässige und unabhängige Hinweise sind für Rezidive oder Gesamtüberleben. Es gibt keine randomisierten kontrollierten Studien, sondern nur systematische Reviews und Metaanalysen auf der Basis von Kohortenstudien [375][376][377]382].…”

Section: Hintergrundunclassified

S3-Leitlinie Magenkarzinom – Diagnostik und Therapie der Adenokarzinome des Magens und des ösophagogastralen Übergangs – Langversion 2.0 – August 2019. AWMF-Registernummer: 032/009OL

Moehler¹,

Al-Batran²,

Andus³

et al. 2019

Z Gastroenterol

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“…MiR is a short (20-24 nucleotides) class of non-coding RNA that can target 3′-untranslated regions (3′-UTRs) of mRNA and regulate its expression by degrading a mRNA or suppressing its translation [8, 9]. Additionally, one kind of miR can target several kinds of mRNAs at post-transcriptional level.…”

Section: Introductionmentioning

confidence: 99%

Prognostic role of microRNAs in human gastrointestinal cancer: A systematic review and meta-analysis

et al. 2017

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BackgroundGastrointestinal cancers (GICs) mainly including esophageal, gastric and colorectal cancer, are the most common cause of cancer-related death and lead into high mortality worldwide. We performed this systematic review and meta-analysis to elucidate relationship between multiple microRNAs (miRs) expression and survival of GIC patients.MethodsWe searched a wide range of database. Fixed-effects and random-effects models were used to calculate the pooled hazard ratio values of overall survival and disease free survival. In addition, funnel plots were used to qualitatively analyze the publication bias and verified by Begg's test while it seems asymmetry.Results60 studies involving a total of 6225 patients (1271 with esophageal cancer, 3467 with gastric cancer and 1517 with colorectal cancer) were included in our meta-analysis. The pooled hazard ratio values of overall survival related to different miRs expression in esophageal, gastric, colorectal and gastrointestinal cancer were 2.10 (1.78-2.49), 2.02 (1.83-2.23), 2.54 (2.14-3.02) and 2.15 (1.99-2.31), respectively. We have identified a total of 59 miRs including 23 significantly up-regulated expression miRs (miR-214, miR-17, miR-20a, miR-200c, miR-107, miR-27a, etc.) and 36 significantly down-regulated expression miRs (miR-433, let-7g, miR-125a-5p, miR-760, miR-206, miR-26a, miR-200b, miR-185, etc.) correlated with poor prognosis in GIC patients. Moreover, 35 of them revealed mechanisms.ConclusionOverall, specific miRs are significantly associated with the prognosis of GIC patients and potentially eligible for the prediction of patients survival. It also provides a potential value for clinical decision-making development and may serve as a promising miR-based target therapy waiting for further elucidation.

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Association of miR-193b Down-regulation and miR-196a up-Regulation with Clinicopathological Features and Prognosis in Gastric Cancer

Cited by 36 publications

References 62 publications

Deregulation of miR-193b affects the growth of colon cancer cells via transforming growth factor-β and regulation of the SMAD3 pathway

Deregulation of miR-193b affects the growth of colon cancer cells via transforming growth factor-β and regulation of the SMAD3 pathway

S3-Leitlinie Magenkarzinom – Diagnostik und Therapie der Adenokarzinome des Magens und des ösophagogastralen Übergangs – Langversion 2.0 – August 2019. AWMF-Registernummer: 032/009OL

Prognostic role of microRNAs in human gastrointestinal cancer: A systematic review and meta-analysis

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