Association of miR-149C&gt;T and miR-499A&gt;G polymorphisms with the risk of hepatocellular carcinoma in the Chinese population

Wang, X H; Wang, F R; Tang, Youming; Zou, Hongzhi; Zhao, Yanqiu

doi:10.4238/2014.july.4.20

Cited by 29 publications

(20 citation statements)

References 17 publications

(23 reference statements)

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“…As for this research, ANRIL showed a negative association with miR-499a, and PDCD4 was a target of miR-499a. miR-499a polymorphism was associated with the progression of several cancers, such as oral squamous cell carcinoma [39], breast cancer [40] and hepatocellular carcinoma [41]. The genetic polymorphism of miR-499 A>G (rs3746444) is also associated with the risk of ischemic stroke in a Chinese people [42].…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Overexpression of lncRNA ANRIL aggravated hydrogen peroxide-disposed injury in PC-12 cells via inhibiting miR-499a/PDCD4 axis-mediated PI3K/Akt/mTOR/p70S6K pathway

Guo

Gao

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Spinal cord injury (SCI) is a grievous neurology-related disorder that causes many devastating symptoms. This research planned to dig the function and latent mechanisms of long noncoding RNA (lncRNA) ANRIL on hydrogen peroxide (H 2 O 2)-disposed injury in PC-12 cells. The PC-12 cells were disposed with H 2 O 2 for 24 h to construct the SCI model. H 2 O 2-disposed PC-12 cells was assessed by detecting cell viability, migration, invasion, apoptosis and autophagy. The level of ANRIL in H 2 O 2-disposed PC-12 cells was analysed, afterwards, the impacts of ANRIL silencing on H 2 O 2-disposed PC-12 cell injury was determined. The regulatory association between ANRIL and miR-499a, between miR-499a and PDCD4, as well as PDCD4 and PI3K/Akt/mTOR/p70S6K signals were investigated. H 2 O 2 produced PC-12 cell injury and promoted the level of ANRIL. Silencing of ANRIL inhibited H 2 O 2-disposed PC-12 cell injury through promoting cell viability, migration, invasion and inhibiting apoptosis and autophagy. Moreover, miR-499a was upregulated after silencing of ANRIL, and inhibition of miR-499a reversed the effects of silencing of ANRIL on H 2 O 2-disposed PC-12 cell injury. Also, PDCD4 was a target of miR-499a. Furthermore, ANRIL silencing alleviated the H 2 O 2-disposed injury in PC-12 cells possible by activating PI3K/Akt/mTOR/p70S6K signals, which was mediated by miR-499a/PDCD4 axis. Our results indicate that high level of ANRIL may sharpen the degree of SCI via targeting miR-499a/PDCD4 axis to regulate the briskness of PI3K/Akt/mTOR/p70S6K signals.

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Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Overexpression of lncRNA ANRIL aggravated hydrogen peroxide-disposed injury in PC-12 cells via inhibiting miR-499a/PDCD4 axis-mediated PI3K/Akt/mTOR/p70S6K pathway

Guo

Gao

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…In particular, ADH7 expression levels gradually increased with an increase in patient age, while CYP26B1 expression gradually declined with a decrease in patient age, indicating that ADH7 and CYP26B1 are correlated with the differential progression of cervical cancer between different age groups. It has been revealed that miR-499a influences the tumorigenesis of several different types of cancer, including breast cancer (43) and hepatocellular carcinoma (44). In addition, miR-499a contributes to the migration and proliferation of hepatitis B virus-associated hepatocellular carcinoma (HCC) cells (45).…”

Section: Discussionmentioning

confidence: 99%

ADH7, miR‑3065 and LINC01133 are associated with cervical cancer progression in different age groups

et al. 2020

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The aim of the present study was to identify potential therapeutic targets that serve crucial roles in the progression of cervical cancer. Clinical data, RNA sequencing (RNAseq)-counts and micro (mi)RNA data regarding cervical squamous cell carcinoma were retrieved from The Cancer Genome Atlas, and analyses were performed using the University of California Santa Cruz database. RNAseq and miRNA data were stratified into 3 groups (according to the patients' age), and genes were re-annotated and preprocessed prior to Mfuzz time clustering analysis. Subsequently, enrichment analyses were performed in order to identify differentially expressed mRNAs (DEmRNAs) and a protein-protein interaction analysis network was constructed. miRNA-gene, miRNA-lncRNA, and long non-coding (lnc)RNA-mRNA pairs were collected and the lncRNA-miRNA-mRNA competing endogenous (ce)RNA network was established. Further enrichment analyses were performed in order to identify crucial mRNAs in the ceRNA network. Finally, survival and drug association analyses were implemented. A total of 269 DEmRNAs [including alcohol dehydrogenase 7 (ADH7), vestigial-like family member 3 (VGLL3) and cytochrome P450, family 26, subfamily B, polypeptide 1 (CYP26B1)], 274 DElncRNAs (including LINC01133) and 16 DEmiRNAs (including miR-3065 and miR-330) were identified. There were 102 lncRNAs, 15 miRNAs, 15 mRNAs and 522 interaction pairs in the ceRNA network. In particular, ADH7 was regulated by miR-3065, and miR-3065 interacted with LINC01133 in the ceRNA network. Furthermore, ADH7 and CYP26B1 were enriched in the retinoic acid metabolic process and the retinol metabolism pathway. ADH7 and VGLL3 were significantly associated with the cervical cancer survival rate. ADH7, VGLL3, CYP26B1, miR-3065, miR-330, miR-499a and LINC01133 play pivotal roles in the progression of cervical cancer in different age groups.

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“…In recent years, several studies have focused on the SNPs in miRNAs and have investigated their potential role in HCC susceptibility [10, 11, 14-28]. A deeper understanding of the association between these polymorphisms and HCC would help early detection and prevention of this deadly disease in high-risk populations such as the Chinese.…”

Section: Discussionmentioning

confidence: 99%

MiR-146a and miR-196a-2 polymorphisms are associated with hepatitis virus-related hepatocellular cancer risk: a meta-analysis

Tian

Wang

Zhu

et al. 2017

Aging

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Previous studies have investigated the role of miR-146a rs2910164 and miR-196a-2 rs11614913 polymorphisms in hepatocellular carcinoma (HCC) susceptibility, but the results are contradictory and few specifically studied hepatitis virus-related HCC. Therefore, we conducted a meta-analysis to evaluate the association between these two polymorphisms and hepatitis virus-related HCC risk. We performed a systematical search in EMBASE, PubMed, Web of Science, CNKI and Wanfang databases as of 25th November, 2016. Finally, we assessed 14 studies involving 3852 cases and 5275 controls. Our results suggest that rs2910164 has a significant association with increased hepatitis virus-related HCC risk in allelic, homozygous, heterozygous, and dominant models (CG+GG vs. CC: OR=1.22, 95% CI=1.06-1.39, P=0.004), particularly in Chinese and HBV-related HCC subgroups. Conversely, rs11614913 was associated with lower hepatitis virus-related HCC risk in the overall analysis under allelic (T vs. C: OR=0.85, 95% CI=0.74-0.98, P=0.02), homozygous, dominant and recessive models. Subgroup analyses showed decreased risk in Chinese, HBV- and HCV-related HCC. In conclusion, miR-146a C>G (rs2910164) can increase HBV-related HCC risk while miR-196a-2 C>T (rs11614913) may decrease the risk of HBV- and HCV-related HCC, especially in the Chinese population. Further, large-scale studies including other races are required to confirm these findings.

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Association of miR-149C>T and miR-499A>G polymorphisms with the risk of hepatocellular carcinoma in the Chinese population

Cited by 29 publications

References 17 publications

RETRACTED ARTICLE: Overexpression of lncRNA ANRIL aggravated hydrogen peroxide-disposed injury in PC-12 cells via inhibiting miR-499a/PDCD4 axis-mediated PI3K/Akt/mTOR/p70S6K pathway

RETRACTED ARTICLE: Overexpression of lncRNA ANRIL aggravated hydrogen peroxide-disposed injury in PC-12 cells via inhibiting miR-499a/PDCD4 axis-mediated PI3K/Akt/mTOR/p70S6K pathway

ADH7, miR‑3065 and LINC01133 are associated with cervical cancer progression in different age groups

MiR-146a and miR-196a-2 polymorphisms are associated with hepatitis virus-related hepatocellular cancer risk: a meta-analysis

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