Association of miR-146a polymorphism rs2910164 and type 2 diabetes risk: a meta-analysis

Cheng, Likun; Zhou, Min; Zhang, Dongmei; Chen, Bing

doi:10.1177/0300060520931313

Cited by 10 publications

(11 citation statements)

References 31 publications

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“…The meta-analysis approach is an important and reliable method for identifying associations between genetic variants and diseases based on the results of multiple studies to improve statistical power ( 46 ). Several recent meta-analyses have reported an association between the miR-146a rs2910164 polymorphism and T2DM risk ( 47 – 50 ). First, the results of these meta-analyses differ.…”

Section: Discussionmentioning

confidence: 99%

Association of rs2910164 in miR-146a with type 2 diabetes mellitus: A case–control and meta-analysis study

et al. 2022

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ObjectiveSeveral studies have shown that miR-146a rs2910164 (C > G) is associated with type 2 diabetes mellitus (T2DM) susceptibility, but the results are still controversial. This study is divided into two parts, and one is to explore the relationship between miR-146a rs2910164 polymorphism and the genetic susceptibility of T2DM in Chinese Han population. Second, a meta-analysis on the basis of a larger sample size was used to determine whether this is a susceptibility gene for T2DM.MethodsA case–control study including 574 T2DM patients and 596 controls was used to evaluate the association of miR-146a rs2910164 polymorphism with the risk of T2DM in Chinese Han People. Then, we systematically searched studies investigating the correlation between miR-146a rs2910164 polymorphism and T2DM susceptibility published before April 2022 from PubMed, Web of Science, Wanfang, and China National Knowledge Infrastructure database, and a meta-analysis including six studies was carried out. The results were expressed by odds ratio (OR) and its 95% confidence interval (95% CI).ResultsIn a case–control study, we found that there were no statistical differences in genotype frequencies between T2DM and control group. Subgroup analysis showed that, compared with the CC genotype, CG + GG genotype was associated with a decreased risk of T2DM in the subgroup of individuals ≥ 65 years old (OR = 0.75; 95% CI: 0.58–0.98; Padjusted = 0.032) and BMI < 18.5 (OR = 0.16; 95% CI: 0.03–0.89; Padjusted = 0.037). In overall meta-analysis, significant heterogeneity was detected. No significant association between miR-146a rs2910164 polymorphism and T2DM was observed in all genetic models under random effects models. Subgroup analysis revealed that there was a significant difference in genotype frequencies between the T2DM and control group in recessive model (CC vs. CG + GG: OR = 1.79; 95% CI: 1.08–2.96; PQ = 0.307, I2 = 4.0%) and homozygote model (CC vs. GG: OR = 1.79; 95% CI: 1.07–3.00; PQ = 0.216, I2 = 34.7%) in Caucasians.ConclusionThe results of our study demonstrate that the miR-146a rs2910164 polymorphism might have ethnicity-dependent effects in T2DM and may be related to T2DM susceptibility in Caucasians.

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Section: Discussionmentioning

confidence: 99%

Association of rs2910164 in miR-146a with type 2 diabetes mellitus: A case–control and meta-analysis study

et al. 2022

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“…Recently, the correlation of rs2910164 with T2DM risk was explored by several case-control studies. A meta-analysis suggested an association of rs2910164 in miRNA-146a gene with T2DM risk [29] . However, in that meta-analysis, only 2,069 cases and 1,950 controls were included.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, a meta-analysis has suggested that rs2910164 G allele might be associated with risk of T2DM. However, only four case-control studies with 2,069 cases and 1,950 controls were included [29] , which observations might be under-powered.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, a meta-analysis has suggested that rs2910164 G allele might be associated with risk of T2DM. However, only 4 case–control studies with 2069 cases and 1950 controls were included ( 29 ), and the observations might be underpowered. Additionally, the relationship of miR-196a2 rs11614913 T>C and miR-499 rs3746444 A>G SNPs with the risk of T2DM was also explored.…”

Section: Introductionmentioning

confidence: 99%

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Relationship of microRNA locus with type 2 diabetes mellitus: a case–control study

Huang

Chen

et al. 2021

Endocrine Connections

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Type 2 diabetes mellitus (T2DM) is considered as a metabolic disease with hyperglycemia. Accumulating investigations have explored the important role of hereditary factors for T2DM occurrence. Some functional microRNA (miR) polymorphisms may affect their interactions with target mRNAs and result in an aberrant expression. Thus, miR-variants might be considered as a biomarker of the susceptibility of T2DM. In this study, we recruited 502 T2DM cases and 782 healthy subjects. We selected miR-146a rs2910164 C>G, -196a2 rs11614913 T>C and -499 rs3746444 A>G loci and carried out an investigation to identify whether these miR- loci could influence T2DM occurrence. In this investigation, a Bonferroni correction was harnessed. After adjustment, we found that rs2910164 single nucleotide polymorphism (SNP) was a protective factor for T2DM (GG vs. CC/CG: adjusted P=0.010), especially in never drinking (GG vs. CC/CG: adjusted P=0.001) and ≥24 kg/m2 (GG vs. CC/CG: adjusted P=0.002) subgroups. We also identified that rs11614913 SNP was a protective factor for T2DM in smoking subjects (CC/TC vs. TT: adjusted P=0.002). When we analyzed an interaction of SNP-SNP with the susceptibility of T2DM. Rs11614913/rs3746444, Rs2910164/rs3746444, and rs11614913/rs2910164 combinations were not associated with the risk of T2DM. In summary, the present study highlights that rs2910164 SNP decreases a susceptibility of T2DM, especially in BMI ≥24 kg/m2 and never drinking subgroups. In addition, we also identify that rs11614913 C allele decreases the susceptibility of T2DM significantly in smoking subgroup.

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“…MiR-146a is another important miRNA for diabetic patients. Evidence-based medicine research shows that the expression of circulating miR-146a is abnormal in type 2 diabetes [82]. MiR-146a was downregulated in diabetic patients and obesity.…”

Section: Relationship Between Mirnas and Diabetes Or Associated Complicationsmentioning

confidence: 99%

Curcumin and Its Analogs as Potential Epigenetic Modulators: Prevention of Diabetes and Its Complications

Tang

Liu

et al. 2021

Pharmacology

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Background: The pathobiology of diabetes and associated complications has been widely researched in various countries, but effective prevention and treatment methods are still insufficient. Diabetes is a metabolic disorder of carbohydrates, fats, and proteins caused by an absence of insulin or insulin resistance, which mediates an increase of oxidative stress, release of inflammatory factors, and macro- or micro-circulation dysfunctions, ultimately developing into diverse complications. Summary: In the last decade through pathogenesis research, epigenetics has been found to affect metabolic diseases. Particularly, DNA methylation, histone acetylation, and miRNAs promote or inhibit diabetes and complications by regulating the expression of related factors. Curcumin has a wide range of beneficial pharmacological activities, including anti-inflammatory, anti-oxidation, anticancer, anti-diabetes, anti-rheumatism, and increased immunity. Key Messages: In this review, we discuss the effects of curcumin and analogs on diabetes and associated complications through epigenetics, and we summarize the preclinical and clinical researches for curcumin and its analogs in terms of management of diabetes and associated complications, which may provide an insight into the development of targeted therapy of endocrine diseases.

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Association of miR-146a polymorphism rs2910164 and type 2 diabetes risk: a meta-analysis

Cited by 10 publications

References 31 publications

Association of rs2910164 in miR-146a with type 2 diabetes mellitus: A case–control and meta-analysis study

Association of rs2910164 in miR-146a with type 2 diabetes mellitus: A case–control and meta-analysis study

Relationship of microRNA locus with type 2 diabetes mellitus: a case–control study

Curcumin and Its Analogs as Potential Epigenetic Modulators: Prevention of Diabetes and Its Complications

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