Association of microsatellite markers on chromosomes 6q27 region and 10p15 region with end-stage renal disease in a UK renal transplant population

Currie, Diane; McKnight, Amy Jayne; Patterson, Christopher; Martin, Rosalind; Middleton, D.; Courtney, Aisling E.; Maxwell, Alexander P.

doi:10.1038/jhg.2009.53

Cited by 1 publication

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References 11 publications

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“…Genetic susceptibility to kidney disease has been associated with loci within chromosome 6q22-q27. [7][8][9] However, candidate genes have not been robustly identified. A targeted genome-wide screen identified a single nucleotide polymorphism (SNP), rs1543547 within the MHC class-I related RAET1L gene, that is associated with diabetic nephropathy (P=0.00002, chromosome 6q25.1).…”

Section: Introductionmentioning

confidence: 99%

Genetic Investigation of Major Histocompatibility Complex Class-I Related RAET1 Genes for Association in a Glomerulonephritis Population

Vance

Bennett

Maxwell

et al. 2012

Nephrology Research & Reviews

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Chromosome 6q22-27 harbors risk genes for kidney disease. We evaluated 1434 individuals with glomerulonephritis (cases) and 603 unaffected individuals (controls) for RAET1 genes at 6q22-27 using samples from the Medical Research Council/Kidney Research UK Glomerulonephritis DNA bank in a 2-stage approach. Top ranked single nucleotide polymorphisms were also genotyped in kidney transplant recipients (n=571) and their respective donors (n=520) as controls to evaluate association with end-stage renal disease (ESRD). Provisional data suggested that rs9397070 in the RAET1G gene was associated with susceptibility to glomerulonephritis [Odds ratio (OR) 1.24, 95%; confidence interval (CI): 1.01-1.54, P=0.04] and further supported by additional genotyping (OR 1.22, 95% CI: 1.03-1.42, P=0.02). Genotyping the renal transplant population did not identify any significant association with ESRD. The RAET1 gene family contains candidate genes for kidney disease; however, common RAET1 gene polymorphisms are not identified as strong genetic risk factors for glomerulonephritis in these white populations

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Section: Introductionmentioning

confidence: 99%