2024
DOI: 10.1101/2024.03.14.584993
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Association of microglia loss with hippocampal network impairments as a turning point in the amyloid pathology progression

Giusy Pizzirusso,
Efthalia Preka,
Julen Goikolea
et al.

Abstract: Alzheimer’s disease is a progressive neurological disorder causing memory loss and cognitive decline. The underlying causes of cognitive deterioration and neurodegeneration remain unclear, leading to a lack of effective strategies to prevent dementia. Recent evidence highlights the role of neuroinflammation, particularly involving microglia, in Alzheimer’s disease onset and progression. Characterizing the initial phase of Alzheimer’s disease can lead to the discovery of new biomarkers and therapeutic targets, … Show more

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