Association of methylenetetrahytrofolate reductase (MTHFR) C677T and A1298C polymorphisms with the susceptibility of childhood acute lymphoblastic leukaemia (ALL) in Chinese population

Li, Xiaolei; Qing-chuan, Liao; Zhang, Shunguo; Chen, Minling

doi:10.1186/2047-783x-19-5

Cited by 13 publications

(7 citation statements)

References 23 publications

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“…In addition, frequencies of MTHFR 1298AA, 1289A>C, and 1298CC were significantly different in those two groups. However, no significant different in frequencies of MTHFR 677CC, 677C>T, and 677TT genotypes were observed in this report (Li et al, 2014). Moreover, MTHFR 1298A>C genotype and the 677CC/1298A>C haplotype were significantly associated with reduced the risk of acute myeloid leukemia (AML) compared with AA genotype and 677CC/1298AA haplotype.…”

Section: Introductioncontrasting

confidence: 64%

Mutation Screening and Association Study of the Folylpolyglutamate Synthetase (FPGS) Gene with Susceptibility to Childhood Acute Lymphoblastic Leukemia

Piwkham

Siriboonpiputtana

Beuten

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Association analysis revealed 3 of 6 SNPs to confer significant increase in ALL risk these being rs7039798 (p= 0.014, OR=2.14), rs1544105 (p=0.010, OR= 2.24), and rs10106 (p=0.026, OR= 1.99). Conclusions: These findings suggested that common genetic polymorphisms in the FPGS coding region including rs7039789, rs1544105, and rs10106 are significantly associated with increased ALL risk in Thai children.

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Section: Introductioncontrasting

confidence: 64%

Mutation Screening and Association Study of the Folylpolyglutamate Synthetase (FPGS) Gene with Susceptibility to Childhood Acute Lymphoblastic Leukemia

Piwkham

Siriboonpiputtana

Beuten

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…These findings are consistent with previous research that identified the T allele to be a protective factor [ 21 , 22 , 29 – 36 ], but not with those studies which identified the T allele as a risk factor [ 37 – 39 ]. Additionally in some studies the T allele has been shown to have no association with childhood ALL [ 40 – 54 ]. Table 4 contains a summary of the findings from all of the literature investigating the association between MTHFR genotypes and childhood leukemia risk with a representative sample size (control/case larger than 70/70) and a non-redundant population.…”

Section: Discussionmentioning

confidence: 99%

“…Among the studies, allele T was associated with decreased risk in populations of Taiwan, Serbia, China, Netherlands, Greece, Canada, and UK [ 22 , 30 – 32 , 34 , 36 ], while with increased risk in populations of India [ 38 ]. Others proposed that the T allele was not associated with childhood ALL [ 40 – 54 ]. However, even the people in the same country, for instance Brazil, there was a dramatically different susceptibility to cancer, showing both decreased [ 21 , 35 ] and increased risk [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

The Association of Methylenetetrahydrofolate Reductase Genotypes with the Risk of Childhood Leukemia in Taiwan

et al. 2015

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BackgroundAcute lymphoblastic leukemia (ALL) is the most prevalent type of pediatric cancer, the causes of which are likely to involve an interaction between genetic and environmental factors. To evaluate the effects of the genotypic polymorphisms in methylenetetrahydrofolate reductase (MTHFR) on childhood ALL risk in Taiwan, two well-known polymorphic genotypes of MTHFR, C677T (rs1801133) and A1298C (rs1801131), were analyzed to examine the extent of their associations with childhood ALL susceptibility and to discuss the MTHFR genotypic contribution to childhood ALL risk among different populations.Methodology/Principal FindingsIn total, 266 patients with childhood ALL and an equal number of non-cancer controls recruited were genotyped utilizing PCR-RFLP methodology. The MTHFR C677T genotype, but not the A1298C, was differently distributed between childhood ALL and control groups. The CT and TT of MTHFR C677T genotypes were significantly more frequently found in controls than in childhood ALL patients (odds ratios=0.60 and 0.48, 95% confidence intervals=0.42–0.87 and 0.24–0.97, respectively). As for gender, the boys carrying the MTHFR C677T CT or TT genotype conferred a lower odds ratio of 0.51 (95% confidence interval=0.32–0.81, P=0.0113) for childhood ALL. As for age, those equal to or greater than 3.5 years of age at onset of disease carrying the MTHFR C677T CT or TT genotype were of lower risk (odds ratio= 0.43 and 95% confidence interval=0.26–0.71, P=0.0016).ConclusionsOur results indicated that the MTHFR C677T T allele was a protective biomarker for childhood ALL in Taiwan, and the association was more significant in male patients and in patients 3.5 years of age or older at onset of disease.

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“…According to the inclusion/exclusion criteria, 12 case-control studies (11 articles) [12,13,14,15,16,17,18,19,20,21,22] were included and 103 articles were excluded. The publication year of the included studies ranged from 2004 to 2014.…”

Section: Resultsmentioning

confidence: 99%

Methylenetetrahydrofolate Reductase Polymorphisms and Susceptibility to Acute Lymphoblastic Leukemia in a Chinese Population: A Meta-Analysis

Xiao¹,

Deng²,

Su³

et al. 2014

Oncol Res Treat

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SummaryBackground: Although many epidemiologic studies have investigated the methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and their association with acute lymphoblastic leukemia (ALL), definitive conclusions cannot be drawn. To clarify the effects of MTHFR polymorphisms on the risk of ALL, a meta-analysis was performed in a Chinese population. Materials and Methods: A computerized literature search was carried out in PubMed, the Chinese Biomedicine (CBM) database, China National Knowledge Infrastructure (CNKI) platform, and the Wanfang database (Chinese) to collect relevant articles. Results: A total of 11 articles including 1,738 ALL cases and 2,438 controls were included in this meta-analysis. Overall, a significantly decreased association was found between the MTHFR C677T polymorphism and ALL risk when all studies in Chinese populations were pooled into the meta-analysis. In subgroup analyses stratified by age, ethnicity, and source of controls, the same results were observed in children, in population-based studies, and in people with no stated ethnicity. However, a significantly increased association was also found for MTHFR C677T in hospital-based studies, and for MTHFR A1298C in people with no stated ethnicity. Conclusion: Our results suggest that the MTHFR C677T and A1298C polymorphisms may be potential biomarkers for ALL risk in Chinese populations, and studies with a larger sample size and wider population spectrum are required before definitive conclusions can be drawn.

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Association of methylenetetrahytrofolate reductase (MTHFR) C677T and A1298C polymorphisms with the susceptibility of childhood acute lymphoblastic leukaemia (ALL) in Chinese population

Cited by 13 publications

References 23 publications

Mutation Screening and Association Study of the Folylpolyglutamate Synthetase (FPGS) Gene with Susceptibility to Childhood Acute Lymphoblastic Leukemia

Mutation Screening and Association Study of the Folylpolyglutamate Synthetase (FPGS) Gene with Susceptibility to Childhood Acute Lymphoblastic Leukemia

The Association of Methylenetetrahydrofolate Reductase Genotypes with the Risk of Childhood Leukemia in Taiwan

Methylenetetrahydrofolate Reductase Polymorphisms and Susceptibility to Acute Lymphoblastic Leukemia in a Chinese Population: A Meta-Analysis

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