Association of metformin use with asthma development and adverse outcomes: a systematic review and meta-analysis of observational studies

Abstract

Review question / Objective: 1 Whether metformin can reduce the incidence of asthma in patients with T2D. 2 Whether T2D patients with concurrent asthma can safely use metformin to reduce adverse outcomes. Condition being studied: Recent epidemiological studies suggest that metformin, the first-line medication used for T2D patients, may reduce the risk of asthma exacerbations. Therefore, this article aims to explore two research questions: first, whether metformin can reduce the incidence of asthma in patients with T2D, and second, whether T2D patients with concurrent asthma can safely use metformin to reduce adverse outcomes. This study may shed light on the efficacy of metformin as an adjunct therapy for asthma care in patients with co-morbid T2D.