Association of metabolic syndrome with Alzheimer disease

Vanhanen, Matti; Koivisto, Keijo; Moilanen, Leena; Helkala, Eeva‐Liisa; Hänninen, Tuomo; Soininen, Hilkka; Kervinen, Kari; Ya, Kesäniemi; Laakso, Markku; Kuusisto, Johanna

doi:10.1212/01.wnl.0000234037.91185.99

Cited by 265 publications

(201 citation statements)

References 27 publications

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“…8 Growing evidence suggests that MetS is also harmful to cognition and that the cluster may have predictive value for cognitive decline over and above that of its individual components. [9][10][11][12][13][14][15][16] Older patients with MetS score lower on cognitive tests than agematched healthy adults, particularly on measures of processing speed and executive functioning, 17 cognitive domains that are associated with vascular cognitive impairment. Several studies have shown that middle-aged individuals with MetS are at higher risk of developing dementia in late life, 18 yet accurate prediction of individual cognitive trajectories is difficult due to the low sensitivity of paper-and-pencil screening tests to subtle changes in intellectual functioning.…”

mentioning

confidence: 99%

Functional MR Imaging Evidence of Altered Functional Activation in Metabolic Syndrome

Hoth¹,

Gonzales²,

Tarumi³

et al. 2010

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:MetS is a cluster of risk factors associated with significant cardiovascular morbidity and mortality and diminished cognitive function. Given that little is known about the early signs of brain vulnerability related to persistent metabolic dysfunction, we set out to determine whether cognitively healthy middle-aged individuals with MetS exhibit an altered cerebrovascular response to a cognitive challenge relative to those without MetS. MATERIALS AND METHODS: Forty neurologically healthy adults aged 40 -60 years (19 with MetS and 21 healthy controls) performed a 2-back verbal working memory task during fMRI. We compared BOLD responses between the 2 groups in 8 a priori regions of interest previously shown to be associated with the 2-back in patients with cardiovascular disease.

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mentioning

confidence: 99%

Functional MR Imaging Evidence of Altered Functional Activation in Metabolic Syndrome

Hoth¹,

Gonzales²,

Tarumi³

et al. 2010

AJNR Am J Neuroradiol

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“…In one longitudinal study involving 993 elderly persons, MetS was discovered to be a risk factor for accelerated executive function (Trails B) and long-term verbal memory, particularly among women [22]. The study focused on measuring the association between MetS and the trajectories [10]. Gender differences in the association between cognitive function and MetS have not been widely explored.…”

Section: Discussionmentioning

confidence: 99%

“…The report defined MetS as the presence of 3 or more of the following: (i) fasting plasma Several cross-sectional studies have reported 2-to 7-fold increases in the risk of developing cognitive decline [9,10] among those with MetS; nevertheless, other studies have failed to discover an increased risk [11]. Therefore, the association between MetS and the risk of cognitive decline remains unclear.…”

Section: Diagnosis Of Metsmentioning

confidence: 99%

Metabolic Syndrome Predicts Cognitive Decline in Community-Dwelling Elderly People: A 10-Year Cohort Study

Chang¹,

Yen²

2018

Neuropsychiatry

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Background:Cognitive function has been reported to predict subsequent disability and mortality in elderly people. This study aimed to explore whether metabolic syndrome (MetS) resulted in cognitive decline in community-dwelling elderly people or not, accounting for depression and other risk factors during a long-term follow-up period. Methods and Findings:A community-based cohort of 300 older adults was followed up for 10 years. Relationships among MetS, depressive symptoms, and consequent cognitive dysfunction were explored using a logistic regression. The presence of MetS at the baseline visit was associated with a 2.7-fold increase in the risk of cognitive decline after 10 years, and depressive symptoms were associated with a 2.4-fold increase in the risk of cognitive decline in the community-dwelling elderly people. Conclusions:The long-term outcomes of MetS are associated with a significantly increased risk of cognitive decline among community-dwelling elderly people.

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“…The association was not demonstrated in men, in whom the prevalence was 3.8 and 3.9%. 17 However, the sample included few cases of Alzheimer's disease (45 overall) and it also had a smaller sample of men (337 compared with 622 women) and, therefore, the validity of the data in men is not as strong as that in women.…”

Section: Obesity and The Older Womanmentioning

confidence: 99%

“…Data from the longitudinal Framingham Heart Study were analysed to assess the implications of obesity (as measured Figure 4 Risk of Alzheimer's disease in elderly patients, with or without the metabolic syndrome (adapted from Vanhanen et al 17 ).…”

Section: Impact On Life Expectancymentioning

confidence: 99%

Obesity in women: a life cycle of medical risk

Ryan

2007

Int J Obes

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Obesity can have an adverse impact on health at each stage of a woman's life cycle. In young women, obesity has an impact on psychosocial health and, as they grow older and become parents, on their reproductive health. Obesity also imposes a number of serious risks during pregnancy. In older women, obesity is associated with the emergence of a number of related chronic diseases, such as type 2 diabetes and cardiovascular disease, and increased risk for almost all types of cancer. Of concern in the elderly is the increasing evidence that obesity is an independent risk factor for dementia and Alzheimer's disease. Obesity also has a marked impact on life expectancy. The medical risks associated with obesity in women are also important for the woman's children and future generations. There is emerging evidence that nutrition during fetal and early life can influence risk for obesity and chronic diseases for both sexes. International Journal of Obesity (2007) 31, S3-S7; doi:10.1038/sj.ijo.0803729Keywords: women; pregnancy; intergenerational programming; Alzheimer's diseaseIn an obesogenic environment, women are at greater risk for obesity, and especially severe obesity, than men, and they also appear to be at disproportionate risk for some of the complications of obesity. In most developed countries, the rates of obesity are higher in women than men. Also, focus on obesity in women is an important consideration for men because the metabolic status of the mother during pregnancy can impact her children, both boys and girls.The biologic differences between men and women in their risk for obesity and its complications are an important area for research because they can give insights into the mechanisms that underlie obesity and can increase the understanding of obesity in both genders. Adolescence and young adulthoodObesity can have an adverse impact on health at each stage of a woman's life. In young women, obesity has an impact on psychosocial health and, as they grow older and become parents, on their reproductive health.The higher rate of obesity in women compared with men has a number of societal consequences. Compared with men, women suffer more from the stigmatisation imposed by obesity and have lower education levels and rates of marriage. At a socio-economic level, compared with normal weight women, obese women with higher education or in upper white-collar positions have significantly lower incomes. Excess body weight is not associated with similar income disadvantages for men.The social and economic consequences of obesity were demonstrated in a study of a representative sample of 10 039 US adolescent and young adult men and women (aged 16-24 years). On follow-up 7 years after the initial survey, women who had been overweight (defined as body mass index (BMI) above the 95th percentile for age and sex) at baseline had indices of socio-economic status that were worse than those of the normal weight women. The survey showed that they were more likely to have had fewer years of education, to be living in poverty,...

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Association of metabolic syndrome with Alzheimer disease

Abstract: Metabolic syndrome is associated with Alzheimer disease in elderly subjects.

Cited by 265 publications

References 27 publications

Functional MR Imaging Evidence of Altered Functional Activation in Metabolic Syndrome

Functional MR Imaging Evidence of Altered Functional Activation in Metabolic Syndrome

Metabolic Syndrome Predicts Cognitive Decline in Community-Dwelling Elderly People: A 10-Year Cohort Study

Obesity in women: a life cycle of medical risk

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