Association of metabolic syndrome with female pattern hair loss in women: A case–control study

Sayed, Mahira Hamdy El; Abdallah, Magda A.; Aly, Dalia Gamal; Khater, Nohha H.

doi:10.1111/ijd.13303

Cited by 36 publications

(27 citation statements)

References 29 publications

(47 reference statements)

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“…A number of studies have examined links between AGA and cholesterol levels, in particular focusing on cardiovascular disease risk and metabolic syndrome . Recent meta‐analysis by Kim, et al highlighted the association between dyslipidaemia and AGA.…”

Section: Associations Between Cholesterol and Hair Pathologiesmentioning

confidence: 92%

Cholesterol homeostasis: Links to hair follicle biology and hair disorders

Palmer

Blakeborough

Harries

et al. 2019

Experimental Dermatology

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Lipids and lipid metabolism are critical factors in hair follicle (HF) biology, and cholesterol has long been suspected of influencing hair growth. Altered cholesterol homeostasis is involved in the pathogenesis of primary cicatricial alopecia, mutations in a cholesterol transporter are associated with congenital hypertrichosis, and dyslipidaemia has been linked to androgenic alopecia. The underlying molecular mechanisms by which cholesterol influences pathways involved in proliferation and differentiation within HF cell populations remain largely unknown. As such, expanding our knowledge of the role for cholesterol in regulating these processes is likely to provide new leads in the development of treatments for disorders of hair growth and cycling. This review describes the current state of knowledge with respect to cholesterol homeostasis in the HF along with known and putative links to hair pathologies.

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Section: Associations Between Cholesterol and Hair Pathologiesmentioning

confidence: 92%

Cholesterol homeostasis: Links to hair follicle biology and hair disorders

Palmer

Blakeborough

Harries

et al. 2019

Experimental Dermatology

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“…The most common endocrinologic comorbidity that is associated with FPHL is polycystic ovarian syndrome (El Sayed et al, 2016). Metabolic syndrome, which is characterized by obesity, insulin resistance, hypertension, hyperprolactinemia, and raised aldosterone levels, also appears to be frequently associated with FPHL (El Sayed et al, 2016). An increased risk of carotid and coronary artery diseases have also been reported (Arias-Santiago et al, 2010).…”

Section: Comorbiditiesmentioning

confidence: 99%

Female pattern hair loss: A clinical, pathophysiologic, and therapeutic review

Fabbrocini

Cantelli

Masarà

et al. 2018

International Journal of Women's Dermatology

128

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Female pattern hair loss (FPHL) is the most common form of alopecia in women. Affected women may experience psychological distress and impaired social functioning. Early diagnosis and initiation of treatment are desirable because treatments are more effective to avoid the progression of hair loss than stimulating regrowth. Typically, a diagnosis of FPHL can be confirmed by review of a patient's medical history and a physical examination alone. Testing a scalp biopsy is diagnostic but usually not required. In women with signs of hyperandrogenism, an investigation for ovarian or adrenal disorders should be performed. Treatment for FPHL is obscured by myths. The aim of FPHL treatment could be two-fold: Reverse or stabilize the process of hair follicle miniaturization. Mild-to-moderate FPHL in women can be treated with oral antiandrogen therapies (cyproterone acetate and spironolactone) and/or topical minoxidil with good results in many cases. If used correctly, available medical treatments arrest the progression of the disease and reverse miniaturization in most patients with mild-to-moderate FPHL. Hair systems and surgery may be considered for selected cases of severe FPHL.

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“…A case control study of 100 young male patients conducted by Banger et al detected a statistically significant difference regarding the number of individuals in the group of AGA fulfilling the criteria for MeTS in comparison with the control group [ 61 ]. The study by El Sayed et al among 90 female patients with AGA showed a statistically significant increase in the incidence and severity of female pattern hair loss especially in relation to hypertension and obesity (defined by NCEP-ATP III criteria) [ 62 ]. In contrast, another study from Ozbas Gok et al did not prove a relation between AGA and MeTS apart from a difference in systolic pressure between disease-based groups [ 63 ].…”

Section: Sebaceous and Apocrine Glands Disordersmentioning

confidence: 99%

Metabolic syndrome and the skin: a more than superficial association. Reviewing the association between skin diseases and metabolic syndrome and a clinical decision algorithm for high risk patients

Stefanadi

Dimitrakakis

Antoniou

et al. 2018

Diabetol Metab Syndr

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There is ongoing scientific interest regarding comorbidities associated with the metabolic syndrome (MeTS). MeTS comprises a combination of parameters that predispose individuals to the development of type 2 diabetes and cardiovascular disease (CVD). Three or more of the following criteria are necessary: fasting glucose > 110 mg/dl (5.6 mmol/l), hypertriglyceridemia > 150 mg/dl (1.7 mmol/l), HDL levels < 40 mg/dl (men)/< 50 mg/dl (women), blood pressure > 130/85 mmHg, waist circumference (values for Mediterranean populations > 94 cm (men)/> 89 cm (women). In this review we attempted to summarize relevant data by searching dermatological literature regarding associations between various skin conditions and MeTS. A multitude of studies was retrieved and a further goal of the present article is to present plausible mechanistic connections. The severity of skin conditions like psoriasis has been linked with MeTS. Parameters of MeTS like insulin resistance are present in patients with early onset androgenic alopecia, hidradenitis suppurativa acne and rosacea. Since MeTS can lead to CVD and type 2 diabetes early detection of patients would be very important. Also therapeutic intervention on MeTS could lead to improvement on the severity of skin conditions. This reciprocal relationship between skin diseases and MeTS in our opinion holds great interest for further investigation.

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Association of metabolic syndrome with female pattern hair loss in women: A case–control study

Abstract: We demonstrated a significant association between MetS and FPHL. Women with FPHL, particularly if associated with an increased WC or hypertension, should be screened for MetS criteria for early identification and management.

Cited by 36 publications

References 29 publications

Cholesterol homeostasis: Links to hair follicle biology and hair disorders

Cholesterol homeostasis: Links to hair follicle biology and hair disorders

Female pattern hair loss: A clinical, pathophysiologic, and therapeutic review

Metabolic syndrome and the skin: a more than superficial association. Reviewing the association between skin diseases and metabolic syndrome and a clinical decision algorithm for high risk patients

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