and preterm delivery compared with same-sex couples who conceived via ART (Table 2). For example, birth weight was 3429.5 g in naturally conceived births vs 3460.2 g in samesex ART births (adjusted difference, −76.2 g [95% CI, −113 to −39.3 g]; P < .001; low birth weight, 4.9% vs 6.7%, adjusted difference, 0.28 [95% CI, −1.11 to 1.66] percentage points; P = .70). Heterosexual couples who conceived via ART had statistically significantly lower birth weight and gestational age than same-sex couples (eg, birth weight: 3342.9 g vs 3460.2 g; adjusted difference, −97.4 g [95% CI, −134.8 to −59.9 g]; P < .001). Percentages of low birth weight and preterm birth were higher in ART conceptions among heterosexual couples vs same-sex couples but did not reach statistical significance (eg, low birth weight: 8.9% vs 6.7%; adjusted difference, 1.23 [95% CI, −0.17 to 2.65] percentage points; P = .09). The results were qualitatively similar when only considering IVF/ICSI-conceived children (Table 2).Discussion | This study demonstrated that same-sex lesbian couples undergoing ART had more favorable or similar birth outcomes to heterosexual couples who conceived naturally or underwent ART to conceive, suggesting that infertility-related factors rather than reproductive treatments contribute to higher rates of adverse birth outcomes in ART pregnancies. Limitations of the study include that the presence of infertility factors was not directly assessed and the relatively small sample size of same-sex couples reduced the statistical power of the study, particularly in the binary outcomes analyses.