Association of Mean Platelet Volume With Vascular Complications in the Patients With Type 2 Diabetes Mellitus

Abstract

BackgroundDiabetes mellitus (DM) is a global health concern that is predicted to involve over 10% of the adult population by the next decade. Vascular complications are the major source of mortality and morbidity in diabetics. Mean platelet volume (MPV) which indicates platelet activity may play a crucial role in the vascular effects of DM and, hence, can be used as a prognostic marker. We have attempted to study the association of MPV with the glycemic status, duration of diabetes, and presence of vascular complications in diabetics. MethodsA cross-sectional study of 300 patients with type 2 DM aged ≥18 years admitted to the inpatient department of medicine was carried out in a tertiary care hospital. After subgrouping patients according to their glycemic status and MPV, the association between microvascular and macrovascular complications was studied. ResultsThe majority of patients were >60 years of age and an increasing prevalence of vascular complications was noted with increasing age. Forty-six percent and 45% of the patients had microvascular and macrovascular complications, respectively. Ischemic heart disease (IHD) and retinopathy were the most common macrovascular and microvascular complications, respectively. Vascular complications in DM showed a significant association with MPV, fasting blood sugar (FBS), post-prandial blood sugar (PP2BS), glycated hemoglobin (HbA1c), and the duration of diabetes. ConclusionA high MPV was linked to poor glycemic control, a longer duration of diabetes, and an increased prevalence of vascular complications. Hence, MPV could be used as a cost-effective marker to predict vascular complications in patients with type 2 DM.

Correlation of Platelet Indices in Patients With Type 2 Diabetes Mellitus and Associated Microvascular Complications: A Hospital-Based, Prospective, Case-Control Study

“…The mean MPV, PDW, and P-LCR in the patients with diabetic retinopathy were 13.1051±1.34492 fL, 17.9682±2.52669 fL, and 35.373±8.0629%, respectively, which is higher than those without diabetic retinopathy with a p-value of 0.001, 0.012, and 0.020, respectively. This is in accordance with the results of studies, where similar conclusions were drawn [17][18][19]. The mean MPV, PDW, and P-LCR were significantly higher in patients with diabetic neuropathy than those without diabetic neuropathy as also seen in another study.…”

“…18.50-22.90 kg/m 2 ) was 12.0286±1.187 fL, in patients who were overweight (23.00-24.90 kg/m 2 ), it was 12.4273±1.127 fL, in pre-obese (25.00-29.9 kg/m 2 ) patients, it was 12.983±1.227 fL, and in patients who were obese (>30.00 kg/m 2 ), it was 13.952±1.224fL. The p-value is 0.042, which is statistically significant.…”

Mean platelet volume may predict all-cause and cardiovascular mortality among incident peritoneal dialysis patients

“…Increased MPV has been associated with an increased risk of major adverse cardiovascular events and mortality in patients with acute coronary syndrome as well as ischemic stroke and hypertension in the general population [ 5 , 6 ]. In patients with diabetes, increased MPV has been linked to poor glycemic control and an increased risk of diabetic complications [ 3 ]. Hemodialysis patients are at increased risk of cardiovascular morbidity and mortality, and MPV has emerged as a potential biomarker for predicting complications in these patients [ 7 ].…”