Association of mean platelet volume and platelet count with the development and prognosis of ischemic and hemorrhagic stroke

Du, Jun-Rong; Wang, Q.; He, Bo; Liu, P.; Chen, J.-Y.; Quan, He Xiu; Ma, Xiancang

doi:10.1111/ijlh.12474

Cited by 83 publications

(76 citation statements)

References 26 publications

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“…Further, a retrospective study by Lok et al (17) in 2017 which 798 first time acute ischemic stroke patients participated, showed that MPV values were not associated with short-term stroke prognosis and neurological functions. Also, a study compared MPV values of 281 first-episode acute ischemic stroke and 164 first-episode hemorrhagic stroke patients and found that MPV values were high in both groups but it is not associated with the prognosis (5). In contrast, in a 2017 study conducted on 100 acute cerebral infarction patients and 80 healthy controls by Wan and Ma (18), it was found that MPV values were high in the patient group.…”

Section: Discussionmentioning

confidence: 97%

“…Platelets are involved in hemostasis, thrombosis and coagulation processes. Circulating platelets are heterogeneous in size, density, and reactivity, and large platelets are more active metabolically and enzymatically (5). Large platelets produce a greater number of prothrombotic factors such as β-thromboglobulin, thromboxane B2, serotonin, glycoprotein IIIA, and P-selectin, and they are more prone to aggregate.…”

Section: Introductionmentioning

confidence: 99%

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Mean Platelet Volume Values and Its Effects on Prognosis in Patients with Acute Ischemic Stroke

Demir¹

2019

BMB

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Stroke is a rapid onset of focal or global loss of cerebral function and is the most common cause of mortality and morbidity in adulthood cancer and heart disease patients. Although it has been reported that mean platelet volume (MPV) values may be an independent risk factor for the severity and prognosis of stroke, the results of previous studies are inconsistent. The aim of the present study was to determine the MPV values of ischemic stroke patients which reflects the activity and function of platelets and to observe its effect on clinical outcomes. Method: Sixty-two acute ischemic stroke patients were recruited for the study. Clinical information, MPV, platelet, white blood cell (WBC) and neutrophil, CRP and troponin-T levels were obtained. Results: The mean ± standard deviation age was 72.4±12.6 years. At the end of the study, 28 patients were discharged and 34 patients passed away. The frequency of bilateral stroke was higher in deceased patients (p=0.005). In addition, platelet counts were significantly higher in discharged patients (p=0.016). At first admission, MPV values were 10.59±1.01 fL in discharged patients and 11.29±1.12 fL in deceased patients (p=0.029). At the end of the study, MPV values were measured as 11.46±1.28 fL in deceased patient sand 10.47±0.74 fL in discharged patients (p<0.001). WBC and neutrophil counts, troponin-T and CRP values were not significantly different between deceased and discharged patients (p>0.05). Conclusion: Our study indicated that MPV and platelet levels may be associated with mortality in acute ischemic stroke patients and can be used as prognostic markers.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Mean Platelet Volume Values and Its Effects on Prognosis in Patients with Acute Ischemic Stroke

Demir¹

2019

BMB

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“…Studies have shown that each of these indicators is a predictor of stroke prognosis [7,9,27,28]. Further, serum albumin and hemoglobin concentration have predictive value for stroke recurrence and combined events [11,12].…”

Section: Discussionmentioning

confidence: 99%

Hemoglobin, Albumin, Lymphocyte, and Platelet Score is Associated With Adverse Clinical Outcomes of Acute Ischemic Stroke: A Prospective Cohort Study

Tian

Wang

et al. 2020

Preprint

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Background The combined index of hemoglobin, albumin, lymphocyte and platelet (HALP) is considered as a novel score to reflect systemic inflammation and nutritional status. This study aimed to investigate the association between HALP score and adverse clinical events in patients with acute ischemic stroke (AIS). Methods This study prospectively included patients with AIS within 24 hours of admission to the First Affiliated Hospital of Zhengzhou University. The primary outcomes were all-cause death within 90 days and 1 year. The secondary outcomes included stroke recurrence and combined vascular events. The association between HALP score and adverse clinical outcomes was analyzed using Cox proportional hazards. Results A total of 1337 patients were included. Patients in the highest tertile of HALP score had a lower risk of death within 90 days and 1 year (Hazard ratio: 0.20 and 0.30; 95% confidence intervals: 0.06–0.66 and 0.13–0.69, P for trend < 0.01 for all) compared with the lowest tertile after adjusting relevant confounding factors. Similar results were found for secondary outcomes. Subgroup analyses further confirmed these association. Adding HALP score to the conventional risk factors improved prediction of death in patients with AIS within 90 days and 1 year (net reclassification index, 38.63% and 38.68%; integrated discrimination improvement, 2.43% and 2.57%; P < 0.02 for all). Conclusions High HALP score levels were associated with decreased risk of adverse clinical outcomes within 90 days and 1 year after stroke onset, suggesting that HALP score may serve as a powerful indicator for AIS.

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“…The exact mechanism of NVG secondary to RVO or DR is multifactorial and remains unknown. It has been shown that platelets play an important role in the pathophysiology of retinal artery occlusion [27], nonarteritic anterior ischemic optic neuropathy [6], ischemic and hemorrhagic stroke [7], and cardiovascular diseases [28]. In this study, 38 patients with NVG secondary to RVO and 47 patients with NVG secondary to DR were studied with regard to platelet parameters and compared to control subjects.…”

Section: Discussionmentioning

confidence: 99%

“…Platelets play an important role in the pathogenesis of various thrombo-occlusive diseases, such as anterior ischemic optic neuropathy [6], ischemic and hemorrhagic stroke [7], and RVO [8]. Mean platelet volume (MPV) is a major indicator of the production rate and size of platelets, and has been associated with the activities of platelets [9, 10].…”

Section: Introductionmentioning

confidence: 99%

Role of Platelet Parameters on Neovascular Glaucoma: A Retrospective Case-Control Study in China

Cao

Sun

2016

PLoS ONE

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PurposeRetinal vein occlusion (RVO) and diabetic retinopathy (DR) are two major sight-threatening diseases which may lead to neovascular glaucoma (NVG). The aim of this study was to explore the association between platelet parameters and NVG.MethodsA total of 185 subjects were enrolled for the study from January, 2012 to December, 2015 at the Eye-ENT Hospital of Fudan University. Patients include those with NVG secondary to RVO (RVO group, n = 38), patients with NVG secondary to DR (DR group, n = 47), diabetics mellitus without retinopathy (DM group, n = 52), and healthy individuals (control group, n = 48). A complete ophthalmological examination including visual field examination, A-scan ultrasound, Fundus photography, and measurement of platelet parameters were performed for NVG subjects.ResultsThere was no statistical difference in the mean age and gender among the RVO, DR, and control groups (p>0.05). The mean level of platelet distribution width (PDW) was higher (p<0.001) in the RVO group (15.16±2.13fl) and DR group (16.17±1.66fl) when compared with the control group (13.77±2.99fl). The mean plateletcrit (PCT) value of the RVO group (0.229±0.063%) was also higher (p = 0.049) than the control group (0.199±0.045). In the DR group, mean platelet volume (MPV) value (10.72±1.57fl) was significantly higher (p = 0.002) than the control group (9.75±0.89fl). A similar trend was observed when platelet parameters were compared among the 3 groups with respect to age. The mean level of PDW was significantly higher (p<0.001) in the DR group (16.17±1.66fl) compared with the DM group (13.80±3.32fl). Stepwise multiple logistic regression analysis revealed that PDW (OR = 1.44, 95%CI = 1.149–1.805, p = 0.002) and MPV (OR = 1.503, 95%CI = 1.031–2.192, p = 0.034) were associated with the DR group, PDW (OR = 1.207, 95%CI = 1.010–1.443, p = 0.039) and PCT (OR = 1.663, 95%CI = 1.870–2.654, p = 0.036) were associated with the RVO group.ConclusionOur results suggest that increased PDW and MPV are associated with the NVG secondary to DR group, elevated PDW and PCT are associated with the RVO group. It indicates that platelets might be an important factor in the onset and/or development of NVG.

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Association of mean platelet volume and platelet count with the development and prognosis of ischemic and hemorrhagic stroke

Abstract: Increased MPV is an independent risk factor for both strokes. Elevated PLT count increases the risk for ischemic stroke, but decreases the risk for hemorrhagic stroke. However, neither MPV nor PLT count has significant association with the prognosis of either stroke.

Cited by 83 publications

References 26 publications

Mean Platelet Volume Values and Its Effects on Prognosis in Patients with Acute Ischemic Stroke

Mean Platelet Volume Values and Its Effects on Prognosis in Patients with Acute Ischemic Stroke

Hemoglobin, Albumin, Lymphocyte, and Platelet Score is Associated With Adverse Clinical Outcomes of Acute Ischemic Stroke: A Prospective Cohort Study

Role of Platelet Parameters on Neovascular Glaucoma: A Retrospective Case-Control Study in China

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