Association of MBOAT7 gene variant with plasma ALT levels in children: the PANIC study

Viitasalo, Anna; Eloranta, Aino-Maija; Atalay, Mustafa; Romeo, Stefano; Pihlajamäki, Jussi; Lakka, Timo A.

doi:10.1038/pr.2016.139

Cited by 45 publications

(47 citation statements)

References 17 publications

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“…Luukkonen et al replicated effects of the MBOAT7 rs641738 variant on NAFLD with respect to steatosis, necroinflammation and fibrosis in 115 European adults. In a population sample of children from Finland, Viitasalo et al reported that subjects carrying the risk allele of the MBOAT7 polymorphism had higher ALT levels. These data suggest MBOAT7 is important in modulating the development of NAFLD.…”

Section: Discussionmentioning

confidence: 99%

Genetic determinants of hepatic steatosis and serum cytokeratin‐18 fragment levels in Taiwanese children

Lin

Chang

et al. 2018

Liver International

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Section: Discussionmentioning

confidence: 99%

Genetic determinants of hepatic steatosis and serum cytokeratin‐18 fragment levels in Taiwanese children

Lin

Chang

et al. 2018

Liver International

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“…Patients carrying T allele show an enhanced intrahepatic TG content in these two independent cohorts and a higher prevalence of NASH and fibrosis in the LBC cohort, compared with non-carriers (60). Furthermore, children carrying the T allele of MBOAT7 have higher plasma ALT levels, C-reactive protein (CRP) concentration and body fat percentage than the non-carriers (62).…”

Section: The Mboat7 Rs641738 Variant Is Novel a Risk Factor For Nafldmentioning

confidence: 90%

Down-regulation of hepatic MBOAT7 by hyperinsulinemia favors steatosis development

Meroni¹,

Dongiovanni²,

Longo³

et al. 2018

Journal of Hepatology

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“…Other candidate genes associated with NAFLD have been proposed, including a variant (rs641738) in the membrane bound O‐acyltransferase domain containing 7‐transmembrane channel‐like 4 ( MBOAT7 ) gene, which is associated with NAFLD in adults. Children carrying the minor allele of the MBOAT7 gene have higher ALT plasma levels compared to non carriers …”

Section: Genetic Variants Causing Nafld/nashmentioning

confidence: 99%

A narrative review of factors associated with the development and progression if non‐alcoholic fatty liver disease

et al. 2019

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Summary Background With the obesity pandemic, non‐alcoholic fatty liver disease (NAFLD) has become the most prevalent liver disease. NAFLD can progress to non‐alcoholic steatohepatitis (NASH), a potential cause of liver failure. It remains difficult to identify patients at risk for NASH, despite evolving insights in contributing factors, including genetic variance, hormones, adipokines, diet and body‐fat distribution. We aimed to present a broad perspective on these risk factors associated with NAFLD development and progression with a focus on their contribution in different age groups and susceptible high‐risk populations, hereby giving insight in the pathophysiology of NAFLD. Methods Literature was searched for relevant articles on the pathophysiology of NAFLD in different age groups. Results Our review underscores large contributions of diet, with particularly fructose promoting NASH development, and sex hormones, with oestrogens exerting protective effects and androgens negatively influencing NAFLD development. Genetic variation in corresponding pathways might further determine NAFLD progression. Conclusions Changes throughout the transition from childhood to adulthood show that variations in diet, hormone levels and metabolism are related to NAFLD progression. The human body uses different strategies to handle excessive nutrients, but each comes at a price. When corresponding pathways are strained by hormonal or genetic factors, NASH or other symptoms of the metabolic syndrome ensue. Potentially, stratification based on sex, body‐fat distribution, diet, lifestyle, microbiome, adipokines, sex hormones, blood concentrations of liver enzymes, liver histology and genetic pre‐disposition might help to identify patients at increased risk of NASH.

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Association of MBOAT7 gene variant with plasma ALT levels in children: the PANIC study

Abstract: Children carrying the T allele of the MBOAT7 polymorphism had higher plasma ALT than the noncarriers. Children with the MBOAT7, PNPLA3, and TM6SF2 variants had the highest plasma ALT.

Cited by 45 publications

References 17 publications

Genetic determinants of hepatic steatosis and serum cytokeratin‐18 fragment levels in Taiwanese children

Genetic determinants of hepatic steatosis and serum cytokeratin‐18 fragment levels in Taiwanese children

Down-regulation of hepatic MBOAT7 by hyperinsulinemia favors steatosis development

A narrative review of factors associated with the development and progression if non‐alcoholic fatty liver disease

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