Association of matrix metalloproteinase-9 polymorphism with severity of Guillain-Barré syndrome

Hayat, Shoma; Ahmad, Oyishee; Mahmud, Ishtiaq; Howlader, M Zakir Hossain; Islam, Zhahirul

doi:10.1016/j.jns.2020.116908

Cited by 11 publications

(15 citation statements)

References 25 publications

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“…All the patients with GBS received supportive treatment only, neither underwent for intravenous immunoglobulin (IVIg) nor plasma exchange therapy. Three hundred and three healthy individuals (204 males and 99 females) were recruited as healthy controls with a median age of 34 years (Interquartile range, 28–46) 29 . People accompanying the GBS patients during the hospital stay who were genetically unrelated and ethnically matched were recruited as healthy controls.…”

Section: Methodsmentioning

confidence: 99%

“…Three hundred and three patients with GBS (208 males and 95 females) with a median age of 29 years (Interquartile range, participated in this prospective case-control study after providing informed consent. 29 The GBS patients were recruited at the Dhaka Medical College and Hospital (DMCH) from 2010 to 2018, who fulfill the diagnostic criteria of the National Institute of Neurological Disorders and Stroke (NINDS) 30 described by Asbury and Cornblath within the 2 weeks of onset of weakness. All the patients with GBS received supportive treatment only, neither underwent for intravenous immunoglobulin (IVIg) nor plasma exchange therapy.…”

Section: Patients and Controlsmentioning

confidence: 99%

“…Three hundred and three healthy individuals (204 males and 99 females) were recruited as healthy controls with a median age of 34 years (Interquartile range, 28-46). 29 People accompanying the GBS patients during the hospital stay who were genetically unrelated and ethnically matched were recruited as healthy controls. All healthy controls were inhabitants of Bangladesh and geographically located in the same area.…”

Section: Patients and Controlsmentioning

confidence: 99%

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Nucleotide oligomerization domain polymorphism confers no risk to G uillain –B arré syndrome

Hayat¹,

Asad²,

Hasan³

et al. 2022

Acta Neuro Scandinavica

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Objectives: Nucleotide oligomerization domain (NOD) proteins are cytoplasmic receptors that play important roles in host innate immune responses to pathogens by recognizing self or non-self-molecules and have been implicated in many autoimmune diseases including Guillain-Barré syndrome (GBS). The current study investigated whether NOD polymorphisms (NOD1-Glu266Lys, rs2075820, and NOD2-[Arg702Trp, rs2066844 and Gly908Arg, rs2066845]) contribute to ligand sensing and thus affect the susceptibility and/or severity of GBS. Materials and Methods: We determined single nucleotide polymorphisms (SNPs) of NOD gene (NOD1-Glu266Lys and NOD2-[Arg702Trp; Gly908Ar]) in 303 patients with GBS and 303 healthy controls from Bangladesh by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and Sanger sequencing. Genotypes and allele frequencies were compared by performing chi-squared or Fisher's exact test with Yates' continuity correction. Serology for Campylobacter jejuni and anti-GM1 antibodies were determined by enzyme-linked immunosorbent assay (ELISA) techniques.Results: NOD variants (NOD1-Glu266Lys and NOD2-[Arg702Trp; Gly908Arg]) were not associated with susceptibility and severity of GBS when compared with healthy controls and mild or severe form of disease. Moreover, NOD2 polymorphisms showed wild-type NOD2 C2104 and NOD2 G2722, respectively, with homozygous Arg/Arg genotype of NOD2 (Arg702Trp) polymorphism and homozygous Gly/Gly genotype of NOD2 (Gly908Arg) for all study subjects in Bangladesh. Homogenous distribution of NOD1 genotypes was observed in patients with axonal and demyelinating form of GBS.Conclusions: NOD variants confer no risk to the susceptibility and severity of GBS.Moreover, NOD2 polymorphism is rare or absent in patients with GBS as well as in the healthy individuals of Bangladesh.

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Section: Methodsmentioning

confidence: 99%

Section: Patients and Controlsmentioning

confidence: 99%

Section: Patients and Controlsmentioning

confidence: 99%

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Nucleotide oligomerization domain polymorphism confers no risk to G uillain –B arré syndrome

Hayat¹,

Asad²,

Hasan³

et al. 2022

Acta Neuro Scandinavica

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“…This study found that the QALB in the CIDP patients was higher than that in the GBS patients; furthermore, compared with the GBS group, in the CIDP group, QALB was an independent risk factor even when QALB >57.37. Relevant studies have shown that elevated serum matrix metalloproteinase-9 (MMP-9) levels are associated with severe GBS but less associated with GBS with mild symptoms (16). MMP-9 levels are significantly increased in CIDP patients (17).…”

Section: Correlations Of the Qalb In The Gbs Cidp And Control Groupsmentioning

confidence: 99%

The Correlation Among the Immunoglobulin G Synthesis Rate, IgG Index and Albumin Quotient in Guillain-Barré Syndrome and Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Retrospective Case–Control Study

Gong

Zhang

et al. 2021

Front. Neurol.

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Background: The immunoglobulin G synthesis rate (IgG SR) and immunoglobulin G (IgG) index are indicators of abnormal intrathecal humoural immune responses, and the albumin quotient (QALB) is an indicator used to evaluate the completeness of the blood-cerebrospinal fluid barrier (BCB). No systematic reports regarding differences in Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) are available. We assessed differences in the IgG SR, IgG index and QALB between GBS and CIDP patients in a Chinese cohort.Methods: A total of 234 patients were retrospectively enrolled in this study, and 167 clinically confirmed GBS and CIDP patients were selected. Meanwhile, 67 non-GBS and non-CIDP patients requiring cerebrospinal fluid (CSF) examination were enrolled as the control group. The IgG SR, IgG index and QALB were calculated using formulas. The relevant clinical data were subjected to statistical analysis.Results: Among the GBS and CIDP study groups and the control group, the QALB had the highest positive rate (80.00%) in the CIDP group (P < 0.01). The QALB stratification analysis showed that the ranges of 10 < QALB ≤ 30 were dominant in the GBS and CIDP groups, and the positive rate of CIDP was higher than that of GBS. Furthermore, a QALB ≤ 7 was dominant in the control group, and a QALB > 30 was dominant in the CIDP group. In receiver operating characteristic (ROC) curve analysis with the CIDP group as the trial group and the GBS group as the control group, the differences in the QALB were statistically significant (P < 0.01). To achieve a high specificity of 98~99%, the diagnostic cut-off value for the QALB was above 57.37 (sensitivity: 9.33%) or below 0.60 (sensitivity: 4.35%). Multivariate logistic regression analysis showed that the CIDP patients had a QALB higher than 57.37, and compared with that in the GBS patients, the difference in the QALB was statistically significant (P < 0.01).Conclusion: QALB elevation was associated with CIDP, while QALB values above 57.37 or below 0.60 had high specificity in differentiating between GBS and CIDP. In CIDP, the BCB is generally moderately to severely damaged; in GBS, the BCB is generally moderately damaged.

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“…However, not all C. jejuni-infected individuals develop GBS after enteritis 6 . In addition to host susceptibility factors [7][8][9][10] , bacterial virulence factors also function as key regulatory elements that may trigger GBS [11][12][13] . Moreover, the cst-II sialyltransferase gene of C. jejuni, which encodes ganglioside-like structures expressed on the bacterial cell surface, has been linked to GBS 14 .…”

Section: Introductionmentioning

confidence: 99%

CRISPR typing of Campylobacter jejuni reveals a link between CRISPR array preservation and Guillain-Barré syndrome

Hamid¹,

Jahan²,

Hayat³

et al. 2021

Preprint

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Guillain-Barré syndrome (GBS) is a post-infection sequela of Campylobacter jejuni-induced enteritis. Clustered regularly interspaced short palindromic repeats and associated genes (CRISPR-Cas) confers adaptive immunity and plays role in virulence in many bacteria. We investigated C. jejuni CRISPR type (CT) to explore association of CRISPR-Cas with risk of developing GBS. We analysed CRISPR-Cas in C. jejuni isolated from 30 patients with GBS, 60 patients with enteritis and 52 healthy controls from Bangladesh. CRISPR types were determined by PCR followed by CRISPR array sequencing. Statistical and genomic analyses were performed using SPSS and multiple web-based software respectively. We found preserved CRISPR array was significantly more frequent in GBS-related strains than healthy control-related strains (P = 0.02, OR = 2.95). Increased CRISPR array length was significantly associated with GBS compared to healthy control- (P = 0.003, AUC = 0.7) and enteritis-related strains (P = 0.02, AUC = 0.65). We reported 38 new CT found among 70 CRISPR-preserving strains. CT of GBS-related strains were unique from enteritis- and healthy control-related strains. Eighty spacers, including 20 novel spacers, were identified among the CRISPR-preserving strains. CRISPR typing had more discriminatory power than PCR-based subtyping in enteritis- and healthy control-related strains. Further genomic analyses are warranted to elucidate role of the C. jejuni CRISPR array in GBS pathogenesis.

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Association of matrix metalloproteinase-9 polymorphism with severity of Guillain-Barré syndrome

Cited by 11 publications

References 25 publications

Nucleotide oligomerization domain polymorphism confers no risk to G uillain –B arré syndrome

Nucleotide oligomerization domain polymorphism confers no risk to G uillain –B arré syndrome

The Correlation Among the Immunoglobulin G Synthesis Rate, IgG Index and Albumin Quotient in Guillain-Barré Syndrome and Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Retrospective Case–Control Study

CRISPR typing of Campylobacter jejuni reveals a link between CRISPR array preservation and Guillain-Barré syndrome

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