Association of Matrix Metalloproteinase 9 C-1562T Polymorphism with Genetic Susceptibility to Myocardial Infarction: A Meta-Analysis

Abstract

BackgroundMyocardial infarction (MI) is the major cause of death by disease in the world. Many studies have identified the associations between matrix metalloproteinase 9 (MMP9) C-1562T polymorphisms and MI. However, the results remain inconclusive. To clarify the role of MMP9 C-1562T polymorphism in MI risk, we conducted a systematic review and large-scale meta-analysis.MethodsStudies published between January 2005 and March 2014 were obtained from the electronic databases PubMed, Medline, and Embase. The odds ratios (ORs) with 95% CIs were calculated for comparisons of the alleles and genotypes in the overall population and in ethnicity subgroups to measure the strength of genetic associations.ResultsA total of 7 related studies, including 3952 MI cases and 4977 healthy control subjects were included in our meta-analysis. Our results show a statistically significant association between T allele and MI in the overall population (OR = 1.23; 95% CI, 1.02–1.48; P = 0.03). The risk of MI was also significantly higher in patients carrying the T allele (TC + TT genotypes) than in those with the CC genotype (P < 0.05). In stratified analysis by ethnicity, we found the T allele was strongly associated with MI in white populations, whereas in Asian populations there appeared no significant association.ConclusionsOur data show that the MMP9 C-1562T polymorphism is a risk factor associated with increased MI susceptibility in the total population and white populations, although no significant association was observed in Asians populations. Further studies with larger sample sizes and assessing gene–gene and gene–environment interactions are required.

No Association of Genetic Markers with Carotid Intimal Medial Thickness in β-Thalassemia Major Patients

“…21,22 Although previous studies show a positive correlation with the studied variant with the progression of cardiac diseases, a recent meta-analysis could not establish a positive correlation of the studied variant with cardiac diseases in Asian population. 23,24 This study also found no association of the studied variant with CIMT in the β-TM patients.…”

Association of MMP‐9 gene polymorphisms with nephrolithiasis patients

“…[10][11][12] Furthermore, MMP9 is highly expressed in the weak regions of atherosclerotic plaques and may be causally involved in plaque rupture. [13][14][15] The increase in plasma concentrations of MMP9 may be a predictor of cardiovascular disease risk and plasma MMP9 concentrations are elevated in patients with acute myocardial infarction. 16,17 Other studies showed that there was an increased risk for coronary heart disease in patients with kidney stones due to increased risk for CKD.…”

“…[10][11][12] Furthermore, MMP9 is highly expressed in the weak regions of atherosclerotic plaques and may be causally involved in plaque rupture. [13][14][15] The increase in plasma concentrations of MMP9 may be a predictor of cardiovascular disease risk and plasma MMP9…”

Comparison of Risk Factors of Stroke and Myocardial Infarction in Patients 15 to 45 Years in Affiliated Hospitals of Babol University of Medical Sciences

“…Smoking is a major risk factor for stroke and cardiovascular disease even in Asian countries [8,9]. Approximately 90% of all cases of MI are the result of acute occlusive thrombus in coronary artery [2]. Cardiovascular risk factors such as hypertension, hyperlipoproteinaemia, diabetes and smoking, are well accepted [10].…”

“…It is an extreme manifestation of coronary artery disease. The American Heart Association reports that approximately 600,000 new patients sustain MI [2]. Young people (younger than 45 years) 4% to 7% of acute MI formed mainly occurs in men [3].…”