Association of maternal urinary fluoride concentrations during pregnancy with size at birth and the potential mediation effect by maternal thyroid hormones: The Swedish NICE birth cohort

Kampouri, Mariza; Gustin, Klara; Stråvik, Mia; Barman, Malin; Levi, Michael; Daraki, Vasiliki; Jacobsson, Bo; Sandin, Anna; Sandberg, Ann‐Sofie; Wold, Agnes E.; Vahter, Marie; Kippler, Maria

doi:10.1016/j.envres.2022.114129

Cited by 6 publications

(6 citation statements)

References 50 publications

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“…In this context, it has been reported that drinking water is the main contributor to the toxic effects of fluoride 8 , and is positively correlated with plasma fluoride levels in pregnant women 25 . Additionally, our findings are consistent with several studies that found that fluoride was associated with anemia 26 , abortion, low birth weight, preterm birth, and poor APGAR score 9,10,27 . 4 showed that the activities of these two enzymes were significantly (P<0.001) lower in pregnant women with abortion, intrauterine fetal death, preterm birth, and preeclampsia when compared to those with normal pregnancy.…”

Section: Resultssupporting

confidence: 93%

“…However, studies performed on women have focused only on the correlation between plasma or urinary fluoride and pregnancy complications. Therefore, the investigation of other biomarkers is necessary to gain a better understanding of the potential mechanisms by which fluoride could cause women pregnancy complications 9,10 . To our knowledge, this study is the first to investigate the relationship between plasma fluoride levels, oxidative stress, and pregnancy complications in women living in endemic fluorosis areas.…”

Section: Resultsmentioning

confidence: 99%

“…Fluorosis is a public health problem, and is endemic in several countries of the world. The association between this pollutant and pregnancy complications is well established in women living in several endemic fluorosis areas 9,10 . However, to our knowledge, all these studies are focused on the relationship between the prevalence of pregnancy complications and plasma or urinary fluoride levels.…”

Section: Introductionmentioning

confidence: 99%

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Association between Fluoride Toxicity, Oxidative Stress, and Pregnancy Complications in Women Living in Fluorosis Areas

Masnaoui,

Bouchab,

Rahim

et al. 2024

Baghdad Sci.J

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The purpose of this study was to investigate the relationship between high plasma fluoride levels, oxidative stress, and pregnancy complications (abortion, intrauterine fetal death, preterm birth, and preeclampsia) in women living in Settat province, Morocco. Blood samples were collected from pregnant women with normal gestation (n=60), abortion (n=20), intrauterine fetal death (n=10), premature delivery (n=20), and preeclampsia (n=20). Afterwards, plasma fluoride levels and erythrocyte enzymatic activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were determined. The results revealed that plasma fluoride levels were significantly lower in women who had normal pregnancies, with a concentration of 0.030±0.003 mg/l, compared to those presenting with abortion, intrauterine fetal death, preterm birth, and preeclampsia, with concentrations of 0.040±0.002, 0.037±0.002, 0.034±0.004 and 0.034±0.003 mg/l, respectively. In addition, SOD activity was significantly increased in women with pregnancy complications, whereas CAT and GPx activities were decreased compared to women with normal pregnancies. Moreover, there was a strong correlation between plasma fluoride levels, antioxidant activities, and pregnancy complications. The presence of high plasma fluoride levels could lead to an increase in the prevalence of abortion, intrauterine fetal death, preterm birth, and preeclampsia, via the oxidative stress pathway in pregnant women living in Settat province, Morocco.

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Section: Resultssupporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between Fluoride Toxicity, Oxidative Stress, and Pregnancy Complications in Women Living in Fluorosis Areas

Masnaoui,

Bouchab,

Rahim

et al. 2024

Baghdad Sci.J

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“…Our main findings are consistent with a cohort study in Sweden, which found that higher urinary fluoride levels during pregnancy were associated with higher birth weight, birth-weight-for-gestational-age

-scores, and risk of large-for-gestational age births. 17 In this study, median urinary fluoride levels were

, and an increase of

was associated with an increase in birth weight (

; 95% CI: 30, 138) and increased odds of large-for-gestational age (

; 95% CI: 1.03, 1.89). In addition, a study in Mexico found urinary fluoride levels were positively associated with birth-weight-for-gestational-age z -scores, but only in the first trimester, 18 where an increase of

in maternal urinary fluoride above

was associated with an increase in birth-weight z -scores (

; 95% CI: 0.10, 1.48).…”

Section: Discussionmentioning

confidence: 51%

“…For instance, some studies found higher fluoride levels were associated with lower birth weight, 15 whereas others found associations with higher birth weight. 17 , 18 Some studies have found increased risk of preterm birth, 19 others have found the opposite, 16 , 20 and one study found no association with either gestational age or fetal growth. 21 To our knowledge, no studies have been done at the population level, which is an important next step for establishing risk in a general population.…”

Section: Introductionmentioning

confidence: 99%

Water Fluoridation and Birth Outcomes in California

Goin,

Padula,

Woodruff

et al. 2024

Environ Health Perspect

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Background: There is a lack of research on the relationship between water fluoridation and pregnancy outcomes. Objectives: We assessed whether hypothetical interventions to reduce fluoride levels would improve birth outcomes in California. Methods: We linked California birth records from 2000 to 2018 to annual average fluoride levels by community water system. Fluoride levels were collected from consumer confidence reports using publicly available data and public record requests. We estimated the effects of a hypothetical intervention reducing water fluoride levels to (the current level recommended by the US Department of Health and Human Services) and (below the current recommendation) on birth weight, birth-weight-for-gestational age z -scores, gestational age, preterm birth, small-for-gestational age, large-for-gestational age, and macrosomia using linear regression with natural cubic splines and G-computation. Inference was calculated using a clustered bootstrap with Wald-type confidence intervals. We evaluated race/ethnicity, health insurance type, fetal sex, and arsenic levels as potential effect modifiers. Results: Fluoride levels ranged from 0 to , with a median of . There was a small negative association on birth weight with the hypothetical intervention to reduce fluoride levels to [ ; 95% confidence interval (CI): , 0.0] and to ( ; 95% CI: , ). There were small negative associations with birth-weight-for-gestational-age z -scores for both hypothetical interventions ( : ; 95% CI: , 0.000 and : ; 95% CI: , 0.000). We also observed small negative associations for risk of large-for-gestational age for both the hypothetical interventions to [ ; 95% CI: , 0.000 and ( ; 95% CI: , 0.000)]. We did not observe any associations with preterm birth or with being small for gestational age for either hypothetical intervention. We did not observe any associations with risk of preterm birth or small-for-gestational age for either hypothetical intervention. Conclusion: We estimated that a reduction in water fluoride levels would modestly decrease birth weight and birth-weight-for-gestational-age z -scores in California. https://doi.org/10.1289/EHP13732

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Factors influencing the spatial distribution and individual variation in urinary fluoride levels in Tibet, China

et al. 2023

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Association of maternal urinary fluoride concentrations during pregnancy with size at birth and the potential mediation effect by maternal thyroid hormones: The Swedish NICE birth cohort

Cited by 6 publications

References 50 publications

Association between Fluoride Toxicity, Oxidative Stress, and Pregnancy Complications in Women Living in Fluorosis Areas

Association between Fluoride Toxicity, Oxidative Stress, and Pregnancy Complications in Women Living in Fluorosis Areas

Water Fluoridation and Birth Outcomes in California

Factors influencing the spatial distribution and individual variation in urinary fluoride levels in Tibet, China

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