Association of maternal serum homocysteine concentration levels in late stage of pregnancy with preterm births: a nested case–control study

Qiu, Xiantao; Gao, Fei; YuanYuan, Qiu; Bao, Junjie; Gu, Xiaoqiong; Long, Yan; Liu, Fei; Cai, Minmin; Liu, Haiying

doi:10.1080/14767058.2017.1351534

Cited by 17 publications

(20 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Qiu et al (2017) studied maternal serum lipid profiles and homocysteine in late pregnancy and showed higher TC and LDL levels in mothers with preterm delivery than in those with term delivery. In contrast, mothers with term delivery had higher HDL levels compared to those with preterm delivery [29].…”

Section: Discussionmentioning

confidence: 67%

The relationship between lipid profiles in pregnancy and preterm delivery: a systematic review

2018

View full text Add to dashboard Cite

Background: High-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride (TG), and total cholesterol (TC) are associated with maternal hormonal changes which can lead to pregnancy complications. High lipid levels during pregnancy may be accompanied by an increased risk of spontaneous preterm labor. The purpose of this review was to determine the relationship between lipid profiles in pregnancy and preterm delivery. Methods: A systematic search was performed in PubMed, EMBASE, Web of Science, Scopus, and Science Direct databases to find cross-sectional, case-control, and cohort studies on the associations between lipid profiles in pregnancy and preterm delivery. The search results were limited to papers published during 2000-2018. The quality of the selected studies was assessed based on the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist. Finally, a total of 25 eligible high-quality papers were reviewed. Results: A high maternal TG level in the first trimester of pregnancy was identified as a significant risk factor for preterm delivery. Low TG, HDL-cholesterol (HDL-C) and LDL-cholesterol (LDL-C) levels were uniquely associated with an increased risk of preterm delivery. High TC, TG, and LDL-C levels increased the risk of spontaneous preterm labor. A further association was found between high TG and TC levels and an elevated risk of preterm labor before 34 weeks of gestation. The risk of preterm labor before 34 weeks and during the 34th-37th weeks of gestation increased with increasing TG and TC levels. Moreover, overweight women who had a delivery before 34 weeks exhibited significant increases in TC and LDL concentrations during early pregnancy. Conclusion: Lipid metabolism undergoes complicated changes in pregnancy. Lipid levels (LDL, HDL, TC, and TG) above or below the normal range during pregnancy increase the risk of preterm delivery. Considering the significance of maternal lipid metabolism in the incidence of preterm delivery, lipid profile screening in early pregnancy can largely contribute to the prevention of preterm delivery. Further studies are warranted to meticulously examine the effects of lipid profile on preterm delivery.

show abstract

Section: Discussionmentioning

confidence: 67%

The relationship between lipid profiles in pregnancy and preterm delivery: a systematic review

2018

View full text Add to dashboard Cite

show abstract

“…These conclusions are supported by the findings of other authors although the evidence is weak. Kramer et al [9] and Qiu et al [10] proved that sPTD was correlated with elevated maternal serum Hcy level during the second and third trimesters, however; Knudtson et al [11] failed to prove such association. Vollset et al [12] in their large Norwegian study showed significantly higher maternal Hcy levels few years following conception in women with history of preterm labor.…”

Section: Discussionmentioning

confidence: 99%

Maternal serum homocysteine and uterine artery pulsatility index as predictors of spontaneous preterm labor

Murad

Abdelhamid

2018

Evidence Based Women's Health Journal

View full text Add to dashboard Cite

“…According to statistics, perinatal mortality is as high as 70% in low birth weight (LBW) with neonatal weight below 2500 grams (Hack et al 1994;Rutter 1995), most of them are born preterm. Growing evidence has shown that the incidence and development of PTB is a complex process that is influenced by a variety of environmental and genetic factors (He et al 2017;Liu et al 2017;Qiu et al 2017;Xiao et al 2016). Therefore, it is helpful to develop approaches of effective prevention and treatment of neonatal morbidity and mortality by elucidating etiological factors contributing to PTB or LBW.…”

Section: Introductionmentioning

confidence: 99%

Peer Review #1 of "Association of pre-pregnancy body mass index with adverse pregnancy outcome among first-time mothers (v0.2)"

2020

View full text Add to dashboard Cite

Background: Studies have reported an increased risk of adverse pregnancy outcome associated with pre-pregnancy body mass index (BMI). However, the data on such associations in urban areas of southern Chinese women is limited, which drive us to clarify the associations of pre-pregnancy BMI and the risks of adverse pregnancy outcomes (preterm birth (PTB) and low birth weight (LBW)) and maternal health outcomes (gestational hypertension and cesarean delivery). Methods: We performed a hospitalbased case-control study including 3,864 Southern Chinese women who gave first birth to a live singleton infant from January 2015 to December 2015. PTB was stratified into three subgroups according to gestational age (extremely PTB, very PTB and moderate PTB). Besides, we combined birth weight and gestational age to dichotomise as being small for gestational age (SGA, less than the tenth percentile of weight for gestation) and non-small for gestational age (NSGA, large than the tenth percentile of weight for gestation), gestational week was also classified into categories of term, 34-36 week and below 34 week.. We then divided newborns into six groups: (1) term and NSGA; (2) 34-36 week gestation and NSGA; (3) below 34 week gestation and NSGA; (4) term and SAG; (5) 34-36 week gestation and SAG; (6) below 34 week gestation and SAG. Adjusted logistic regression models was used to estimate the odds ratios of adverse outcomes. Results: Underweight women were more likely to give LBW (AOR=1.44, 95% CI 1.11 to 1.89), the similar result was seen in term and SAG as compare with term and NSAG (AOR=1.78, 95% CI 1.45-2.17). Whereas underweight was significantly associated with a lower risk of gestational hypertension (AOR=0.45, 95% CI 0.25-0.82) and caesarean delivery (AOR=0.74, 95% CI 0.62-0.90). The risk of extremely PTB is relatively higher among overweight and obese mothers in a subgroup analysis of PTB (AOR=8.12, 95% CI=1.11 to

show abstract

Association of maternal serum homocysteine concentration levels in late stage of pregnancy with preterm births: a nested case–control study

Abstract: Higher maternal serum Hcy levels were associated with preterm birth and neonatal body weight. Elevated maternal serum levels of Hcy might serve as a biomarker for preterm birth prediction.

Cited by 17 publications

References 12 publications

The relationship between lipid profiles in pregnancy and preterm delivery: a systematic review

The relationship between lipid profiles in pregnancy and preterm delivery: a systematic review

Maternal serum homocysteine and uterine artery pulsatility index as predictors of spontaneous preterm labor

Peer Review #1 of "Association of pre-pregnancy body mass index with adverse pregnancy outcome among first-time mothers (v0.2)"

Contact Info

Product

Resources

About