Association of Maternal Serum CRP, IL-6, TNF-α, Homocysteine, Folic Acid and Vitamin B12 Levels with the Severity of Preeclampsia and Fetal Birth Weight

Güven, Melih; Coşkun, Ayhan; Ertaş, İbrahim Egemen; Aral, Murat; Zencirci, Beyazit; Öksüz, Hafize

doi:10.1080/10641950802601179

Cited by 129 publications

(125 citation statements)

References 26 publications

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“…Several studies have demonstrated a shift from Th2 to Th1 in preeclampsia with an increase of pro-inflammatory and a decrease of antiinflammatory cytokines (12,(21)(22)(23). We failed to demonstrate this suggested shift by mere cytokine analysis, although levels of the Th2 cytokine IL-4 were decreased in preeclamptic women.…”

Section: Discussioncontrasting

confidence: 62%

Biomarkers of coagulation, inflammation and angiogenesis are independently associated with preeclampsia

Boij

Berg²,

Ernerudh

et al. 2012

Journal of Reproductive Immunology

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Section: Discussioncontrasting

confidence: 62%

Biomarkers of coagulation, inflammation and angiogenesis are independently associated with preeclampsia

Boij

Berg²,

Ernerudh

et al. 2012

Journal of Reproductive Immunology

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“…Thirty‐two studies in total reported on C‐reactive protein levels,21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52 of which 17 were applicable for meta‐analysis 21, 22, 23, 29, 30, 31, 32, 33, 34, 37, 38, 39, 41, 42, 47, 49, 50. A significantly higher C‐reactive protein was found in women with pre‐eclampsia than in non‐hypertensive controls ( Figure 2), and this correlation was stronger in severe than in mild pre‐eclampsia ( Figure 3).…”

Section: Resultsmentioning

confidence: 99%

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

et al. 2017

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Evidence accumulates for associations between hypertensive pregnancy disorders and increased cardiovascular risk later. The main goal of this study was to explore shared biomarkers representing common pathogenic pathways between heart failure with preserved ejection fraction (HFpEF) and pre‐eclampsia where these biomarkers might be potentially eligible for cardiovascular risk stratification in women after hypertensive pregnancy disorders. We sought for blood markers in women with diastolic dysfunction in a first literature search, and through a second search, we investigated whether these same biochemical markers were present in pre‐eclampsia.This systematic review and meta‐analysis presents two subsequent systematic searches in PubMed and EMBASE. Search I yielded 3014 studies on biomarkers discriminating women with HFpEF from female controls, of which 13 studies on 11 biochemical markers were included. Cases had HFpEF, and controls had no heart failure. The second search was for studies discriminating women with pre‐eclampsia from women with non‐hypertensive pregnancies with at least one of the biomarkers found in Search I. Search II yielded 1869 studies, of which 51 studies on seven biomarkers were included in meta‐analyses and 79 studies on 12 biomarkers in systematic review.Eleven biological markers differentiated women with diastolic dysfunction from controls, of which the following 10 markers differentiated women with pre‐eclampsia from controls as well: C‐reactive protein, HDL, insulin, fatty acid‐binding protein 4, brain natriuretic peptide, N terminal pro brain natriuretic peptide, adrenomedullin, mid‐region pro adrenomedullin, cardiac troponin I, and cancer antigen 125.Our study supports the hypothesis that HFpEF in women shares a common pathogenic background with pre‐eclampsia. The biomarkers representing inflammatory state, disturbances in myocardial function/structure, and unfavourable lipid metabolism may possibly be eligible for future prognostic tools.

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“…An interventional trial has demonstrated that folate supplementation in the second trimester of pregnancy significantly reduces both serum homocysteine levels and the risk of preeclampsia 23 . Markedos et al 6 , Braekke et al 10 and Guven et al 24 , studies showed that maternal circulating concentrations of vitamins B12 and folic acid are not significantly different in hyperhomocysteinemic preeclamtic group compared with normal pregnant women. Lopez et al 7 found that the levels of homocysteine and folate are increased in preeclampsia, but values of vitamin B12 are not changed compared with normal pregnancy.…”

Section: Discussionmentioning

confidence: 97%

Circulating levels of homocysteine in preeclamptic women

Khosrowbeygi

Ahmadvand

2011

Bangladesh Med Res Counc Bull

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It has been hypothesized that maternal hyperhomocysteinemia to be associated with preeclampsia. The aims of the present study were to examine maternal serum levels of total homocysteine in preeclamptic women and its association with the severity of the disease. The study population consisted of 30 preeclamptic patients and 30 matched healthy pregnant women. Serum levels of total homocysteine were assessed using enzyme immunoassay method. Maternal serum levels of total homocysteine were significantly higher in preeclamptic group than in normal pregnant women. Women with severe preeclampsia had higher serum levels of total homocysteine than mild preeclamptic patients. Levels of total homocysteine correlated positively with systolic blood pressure values in preeclamptic women. In summary, maternal serum levels of total homocysteine were increased in preeclamptic women and hyperhomocysteinemia was associated with severity of preeclampsia.

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Association of Maternal Serum CRP, IL-6, TNF-α, Homocysteine, Folic Acid and Vitamin B12 Levels with the Severity of Preeclampsia and Fetal Birth Weight

Abstract: Elevated maternal serum levels of hs-CRP, TNF- alpha, IL-6 and homocysteine in preeclamptic women correlate with fetal birth weight in the early third trimester.

Cited by 129 publications

References 26 publications

Biomarkers of coagulation, inflammation and angiogenesis are independently associated with preeclampsia

Biomarkers of coagulation, inflammation and angiogenesis are independently associated with preeclampsia

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

Circulating levels of homocysteine in preeclamptic women

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