Association of maternal serum copper during early pregnancy with the risk of spontaneous preterm birth: A nested case-control study in China

Hao, Yongxiu; Pang, Yiming; Yan, Hao-Jie; Zhang, Yali; Liu, Jufen; Jin, Lei; Yan, Lailai; Chen, Da; Hu, Ligang; Liu, Qian; Qin, Yueping; Wang, Bin; Li, Zhiwen; Ye, Rongwei; Zhang, Le; Ren, Aiguo

doi:10.1016/j.envint.2018.11.009

Cited by 43 publications

(36 citation statements)

References 26 publications

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“…Very little information was found in the literature on the maternal serum concentrations of the trace elements selenium, copper, and zinc in pregnancy and their associations with spontaneous preterm birth in the African region. Comparing with researches from other regions, some studies have found maternal concentrations of these trace elements to be associated with preterm birth, while others have reported no associations [20,24,[35][36][37][38][39]. In this study, higher selenium concentrations were observed in the maternal serum of preterm birth, but this was not significant.…”

Section: Resultscontrasting

confidence: 92%

“…This finding is consistent with findings of other studies reported in the literature [20,24,37]. Hao et al collected plasma and serum at the first prenatal visit between 4 and 22 gestation weeks and found that the overall medium maternal serum copper concentrations were significantly higher for preterm births than for term births in the Chinese population [38]. Contrary to the findings of other studies in the literature, this study found that the maternal serum concentration of zinc was higher in women with preterm birth than in those delivering at term, and a unit increase of zinc had a 7-fold increased risk of having a preterm birth.…”

Section: Resultssupporting

confidence: 90%

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Maternal Serum Concentrations of Selenium, Copper, and Zinc during Pregnancy Are Associated with Risk of Spontaneous Preterm Birth: A Case-Control Study from Malawi

Chiudzu

Choko

Maluwa

et al. 2020

Journal of Pregnancy

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Preterm birth is delivery before 37 completed weeks. A study was conducted to evaluate the association of maternal serum concentrations of selenium, copper, and zinc and preterm birth. There were 181 women in this nested case-control study, 90/181 (49.7%) term and 91/181 (50.3%) preterm pregnant women. The overall mean serum concentration of selenium was 77.0, SD 19.4 μg/L; of copper was 2.50, SD 0.52 mg/L; and of zinc was 0.77, SD 0.20 mg/L with reference values of 47-142 μg/L, 0.76-1.59 mg/L, and 0.59-1.11 mg/L, respectively. For preterm birth, mean serum concentration for selenium was 79.7, SD 21.6 μg/L; for copper was 2.61, SD 0.57 mg/L; and for zinc was 0.81, SD 0.20 mg/L compared to that for term births: selenium (74.2; SD 16.5 μg/L; p=0.058), copper (2.39; SD 0.43 mg/L; p=0.004), and zinc (0.73; SD 0.19 mg/L; p=0.006), respectively. In an adjusted analysis, every unit increase in maternal selenium concentrations gave increased odds of being a case OR 1.01 (95% CI: 0.99; 1.03), p=0.234; copper OR 1.62 (95% CI: 0.80; 3.32), p=0.184; zinc OR 6.88 (95% CI: 1.25; 43.67), p=0.032. Results show that there was no deficiency of selenium and zinc and there were high serum concentrations of copper in pregnancy. Preterm birth was associated with higher maternal serum concentrations of copper and zinc.

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Section: Resultscontrasting

confidence: 92%

Section: Resultssupporting

confidence: 90%

Maternal Serum Concentrations of Selenium, Copper, and Zinc during Pregnancy Are Associated with Risk of Spontaneous Preterm Birth: A Case-Control Study from Malawi

Chiudzu

Choko

Maluwa

et al. 2020

Journal of Pregnancy

View full text Add to dashboard Cite

show abstract

“…This finding is consistent with findings of other studies reported in the literature[21], [25], [38]. Hao et al collected plasma and serum at first prenatal visit between 4-22 gestation weeks and found that the overall medium maternal serum copper concentrations were significantly higher for preterm birth than term births in the Chinese population[39]. Contrary to the findings of other studies in the literature, this study found that maternal serum concentration of zinc were higher in women with preterm birth than those delivering at term and a unit increase of zinc had a 7-fold increase risk of having a preterm birth.…”

Section: Resultssupporting

confidence: 91%

Maternal Serum Concentrations of Selenium, Copper and Zinc during Pregnancy are associated with Risk of Spontaneous Preterm Birth: A case-control study from Malawi

Chiudzu

Choko

Maluwa

et al. 2020

Preprint

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Preterm birth is delivery before 37 completed weeks. A study was conducted to evaluate the association of maternal serum concentrations of selenium, copper, and zinc, and preterm birth. There were 181 women in this nested case- control study, 90/181 (49.7%) term and 91/181 (50.3%) preterm pregnant women. The overall mean serum concentration of selenium was 77.0; SD 19.4microg/L, copper was 2.50; SD 0.52 mg/L and zinc was 0.77; SD 0.20 mg/L with reference values of 47-142microg/L, 0.76-1.59mg/L and 0.59-1.11 mg/L, respectively. For preterm birth, mean serum concentrations for selenium was 79.7; SD 21.6microg/L, copper was 2.61; SD 0.57 mg/L, and zinc was 0.81; SD 0.20 mg/L compared to that of term births: selenium (74.2; SD 16.5microg/L; p=0.058), copper (2.39; SD 0.43 mg/L; p = 0.004), and zinc (0.73; SD 0.19 mg/L; p = 0.006) respectively. In adjusted analysis, every unit increase in maternal selenium concentrations gave increased odds of being a case OR 1.01 (95% CI: 0.99; 1.03), p=0.234, copper OR 1.62 (95% CI: 0.80; 3.32); p = 0.184, zinc OR 6.88 (95% CI: 1.25; 43.67); p=0.032. Results show that there was no deficiency of selenium, and zinc; and high serum concentrations of copper in pregnancy. Preterm birth was associated with higher maternal serum concentrations of copper and zinc.

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“…Another study also showed that Cu protects against spontaneous miscarriages [16]. However, elevated Cu levels in the first trimester of pregnancy may lead to later pregnancy complications, including spontaneous miscarriages [199]. Li et al [200] concluded that too much Cu can increase the incidence of gestational diabetes, which-if untreated-can lead to macrosomia, intrauterine hypotrophy, birth defects, and miscarriages.…”

Section: Copper (Cu)mentioning

confidence: 99%

The Role of Fe, Zn, and Cu in Pregnancy

2020

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Iron (Fe), copper (Cu), and zinc (Zn) are microelements essential for the proper functioning of living organisms. These elements participatein many processes, including cellular metabolism and antioxidant and anti-inflammatory defenses, and also influence enzyme activity, regulate gene expression, and take part in protein synthesis. Fe, Cu, and Zn have a significant impact on the health of pregnant women and in the development of the fetus, as well as on the health of the newborn. A proper concentration of these elements in the body of women during pregnancy reduces the risk of complications such as anemia, induced hypertension, low birth weight, preeclampsia, and postnatal complications. The interactions between Fe, Cu, and Zn influence their availability due to their similar physicochemical properties. This most often occurs during intestinal absorption, where metal ions compete for binding sites with transport compounds. Additionally, the relationships between these ions have a great influence on the course of reactions in the tissues, as well as on their excretion, which can be stimulated or delayed. This review aims to summarize reports on the influence of Fe, Cu, and Zn on the course of single and multiple pregnancies, and to discuss the interdependencies and mechanisms occurring between Fe, Cu, and Zn.

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Association of maternal serum copper during early pregnancy with the risk of spontaneous preterm birth: A nested case-control study in China

Cited by 43 publications

References 26 publications

Maternal Serum Concentrations of Selenium, Copper, and Zinc during Pregnancy Are Associated with Risk of Spontaneous Preterm Birth: A Case-Control Study from Malawi

Maternal Serum Concentrations of Selenium, Copper, and Zinc during Pregnancy Are Associated with Risk of Spontaneous Preterm Birth: A Case-Control Study from Malawi

Maternal Serum Concentrations of Selenium, Copper and Zinc during Pregnancy are associated with Risk of Spontaneous Preterm Birth: A case-control study from Malawi

The Role of Fe, Zn, and Cu in Pregnancy

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