Association of maternal prenatal psychological stressors and distress with maternal and early infant faecal bacterial profile

Naudé, Petrus J.W.; Claassen, Shantelle; Gardner-Lubbe, Sugnet; Botha, Gerrit; Kaba, Mamadou; Zar, Heather J.; Nicol, Mark P.; Stein, Dan J.

doi:10.1101/713602

Cited by 4 publications

(2 citation statements)

References 69 publications

(87 reference statements)

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“…There is evidence to confirm that the family Brachyspiraceae and Peptostreptococcaceae are associated with intestinal bacterial infection 57,58 . Fecal specimens from mothers exposed to intimate partner violence have lower proportions of Peptostreptococcaceae at birth 59 . This finding provides insight into the involvement of the gut bacteria linking maternal psychological adversity and the maturing infant brain.…”

Section: Discussionmentioning

confidence: 97%

CD36 deficiency affects depressive-like behaviors possibly by modifying gut microbiota and the inflammasome pathway in mice

Bai

Wang

et al. 2021

Transl Psychiatry

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Both inflammatory processes and gut microbiota have been implicated in the pathophysiology of depressive disorders. The class B scavenger receptor CD36 is involved in the cytotoxicity associated with inflammation. However, its role in depression has not yet been examined. In this study, we investigated whether CD36 affects depression by modulating the microbiota-gut-inflammasome-brain axis. We used CD36−/− (knockout) mice subjected to chronic social defeat stress, and measured the expression of CD36 in these depressed mice and in patients with depression. The hippocampus of CD36−/− mice was used to investigate changes in the NLRP3 inflammasome signaling pathway. The 16S rRNA gene sequence-based approach was used to compare the cecal microbial communities in CD36−/− and WT mice. The CD36 deficiency in CD36−/− mice alleviated chronic stress-induced depression-like behaviors. CD36 was upregulated in depressed mice as well as in depressed patients. Furthermore, the NLRP3 inflammasome signaling pathway was downregulated in the hippocampus of CD36−/− mice. The Simpson Diversity Index revealed increased cecal bacterial alpha-diversity in the CD36−/− mice. Among genera, Bacteroides, Rikenella, and Alloprevotella were significantly more abundant in the CD36−/− mice, whereas Allobaculum was less abundant, consistent with the attenuated inflammation in the hippocampus of CD36−/− mice. Our findings suggest that CD36 deficiency changes the gut microbiota composition, which in turn may impact depressive-like behaviors by affecting the inflammasome pathway.

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Section: Discussionmentioning

confidence: 97%

CD36 deficiency affects depressive-like behaviors possibly by modifying gut microbiota and the inflammasome pathway in mice

Bai

Wang

et al. 2021

Transl Psychiatry

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“…Infants exposed to prenatal stress have also been shown to have increased levels of Firmicutes (Weissella) and Enterobacteriaceae (unclassified genera) in the meconium [105], the latter of which has been found to be characteristic of depression in later life [106]. Animal studies have also found similar results, whereby prenatally stressed monkey infants were seen to have an altered microbiota composition compared to control infants, with significantly lower levels of lactobacilli and bifidobacteria [107].…”

Section: Prenatal Stressmentioning

confidence: 88%

The contrasting human gut microbiota in early and late life and implications for host health and disease

Skillington

Mills

Gupta³

et al. 2021

NHA

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The gut microbiota plays a significant role in health and development from birth and continues to affect several processes throughout life and into old age. During both infancy and old age, the trajectory of the gut microbiota changes with contrasting consequences at both stages for the host. The infant gut is unstable, and colonization is influenced by a variety of perinatal and postnatal factors. Many of these factors can contribute to an altered microbiota profile in infancy which can be associated with negative consequences later in life such as allergies, obesity, and neuropsychiatric disorders. The late-life gut microbiota is influenced by physiological changes within the host, illness, diet and lifestyle that impact its composition and functionality. Indeed, reduced microbial diversity, loss of beneficial microorganisms and increased pathobionts are key signatures of the elderly microbiome. Such changes have been associated with degenerative diseases including inflammageing, Alzheimer’s disease, Parkinson’s disease, and increased risk of infection with Clostridioides difficile. Here, we examine early- and late-life factors that contribute to contrasting gut microbiota disturbances and the consequences associated with these disruptions. Finally, we provide compelling evidence of nutritional and probiotic/prebiotic interventions that may help alleviate the effects of gut microbiota changes into old age.

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Exposure to Intimate Partner Violence and Children’s Physiological Functioning: A Systematic Review of the Literature

et al. 2022

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Association of maternal prenatal psychological stressors and distress with maternal and early infant faecal bacterial profile

Cited by 4 publications

References 69 publications

CD36 deficiency affects depressive-like behaviors possibly by modifying gut microbiota and the inflammasome pathway in mice

CD36 deficiency affects depressive-like behaviors possibly by modifying gut microbiota and the inflammasome pathway in mice

The contrasting human gut microbiota in early and late life and implications for host health and disease

Exposure to Intimate Partner Violence and Children’s Physiological Functioning: A Systematic Review of the Literature

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